Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis by Park, Yumi, Pacitto, Angela, Bayliss, Tracy, Cleghorn, Laura A. T, Wang, Zhe, Hartman, Travis, Arora, Kriti, Ioerger, Thomas R, Sacchettini, Jim, Rizzi, Menico, Donini, Stefano, Blundell, Tom L, Ascher, David B, Rhee, Kyu, Breda, Ardala, Zhou, Nian, Dartois, Veronique, Jonnala, Surendranadha Reddy, Via, Laura E, Mizrahi, Valerie, Epemolu, Ola, Stojanovski, Laste, Simeons, Fred, Osuna-Cabello, Maria, Ellis, Lucy, MacKenzie, Claire J, Smith, Alasdair R. C, Davis, Susan H, Murugesan, Dinakaran, Buchanan, Kirsteen I, Turner, Penelope A, Huggett, Margaret, Zuccotto, Fabio, Rebollo-Lopez, Maria Jose, Lafuente-Monasterio, Maria Jose, Sanz, Olalla, Diaz, Gracia Santos, Lelièvre, Joël, Ballell, Lluis, Selenski, Carolyn, Axtman, Matthew, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Bösche, Markus, Drewes, Gerard, Freiberg, Gail M, Kurnick, Matthew D, Srikumaran, Myron, Kempf, Dale J, Green, Simon R, Ray, Peter C, Read, Kevin, Wyatt, Paul, Barry, Clifton E, Boshoff, Helena I

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Rapid access towards follow-up NOP receptor agonists using a knowledge based approach by Palin, Ronald, Clark, John K., Evans, Louise, Feilden, Helen, Fletcher, Dan, Hamilton, Niall M., Houghton, Andrea K., Jones, Philip S., McArthur, Duncan, Montgomery, Brian, Ratcliffe, Paul D., Smith, Alasdair R.C., Sutherland, Aaron, Weston, Mark A., Wishart, Grant

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Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists by Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

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Metagenomics of the Svalbard reindeer rumen microbiome reveals abundance of polysaccharide utilization loci by Pope, Phillip B, Mackenzie, Alasdair K, Gregor, Ivan, Smith, Wendy, Sundset, Monica A, McHardy, Alice C, Morrison, Mark, Eijsink, Vincent G H

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The intensive care delirium research agenda: a multinational, interprofessional perspective by Pandharipande, Pratik P., Ely, E. Wesley, Arora, Rakesh C., Balas, Michele C., Boustani, Malaz A., La Calle, Gabriel Heras, Cunningham, Colm, Devlin, John W., Elefante, Julius, Han, Jin H., MacLullich, Alasdair M., Maldonado, José R., Morandi, Alessandro, Needham, Dale M., Page, Valerie J., Rose, Louise, Salluh, Jorge I. F., Sharshar, Tarek, Shehabi, Yahya, Skrobik, Yoanna, Slooter, Arjen J. C., Smith, Heidi A. B.

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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial by Folegatti, Pedro M, Bibi, Sagida, Chappell, Harry, Fedosyuk, Sofiya, Gbesemete, Diane, Kelly, Elizabeth J, Makinson, Rebecca, Rawlinson, Thomas, Ross-Russell, Amy L, Saich, Stephen, Smith, Catherine C, Tarrant, Richard, Thomas, Kelly M, Warren, Sarah C, Lambe, Teresa, Adams, Kelly, Ali, Aabidah, Allen, Lauren, Baker, Natalie, Barrett, Kelly, Bellamy, Duncan, Berg, Adam, Beveridge, Amy, Bewley, Kevin, Bijker, Else M., Boland, Elena, Bormans, Daan, Bower, Thomas, Boyd, Amy, Brenner, Tanja, Buttigieg, Karen R., Cao, Michelangelo, Chapman, David, Chelysheva, Irina, Cifuentes, Liliana, Collins, Sarah, Conlon, Christopher P., Davis, Judith, Dong, Tao, Drake, Jonathan, Fisher, Richard, Garlant, Harriet, Gavrila, Madita, Gibbons, Felicity, Gill, Hardeep, Hart, Thomas C., Hartnell, Birgit, Haskell, Louise, Hawkins, Sophia, Hermosin Herrera, Macarena, Hill, David, Hill, Jennifer, Howes, Jessica, Jackson, Susan, Joshi, Amar, Kelly, Dearbhla M., King, Lloyd D.W., Knott, Daniel, Lee, Kim Y.N., Leung, Stephanie, Liu, Shuchang, Loew, Lisa, Madhavan, Meera, Marius, Phedra, Marshall, Julia L., Martin, Jane, Moore, Maria, Morris, Susan J., O'Reilly, Peter John, Owino, Nelly, Patel, Bhumika, Patrick-Smith, Maia, Perring, James, Phillips, Daniel J., Poulton, Ian, Presland, Laura, Pulido, David, Rajapaska, Durga, Ramos Lopez, Fernando, Rollier, Christine S., Romani, Rossana, Sedik, Cynthia, Seddiqi, Samiullah, Segireddy, Rameswara R., Sharpe, Hannah R., Silva-Reyes, Laura, Smith, David J., Smith, Daniel C., Smith, Nicholas, Stockley, David, Summerton, Eloise, Szigeti, Anna, Taylor, Ursula, Tonks, Susan, Tree, Julian A., Truby, Adam, Varughese, Rachel, Woodyer, Mark, Worth, Andrew T., Yao, Xin Li

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One-Third of Reef-Building Corals Face Elevated Extinction Risk from Climate Change and Local Impacts by Carpenter, Kent E, Abrar, Muhammad, Aeby, Greta, Aronson, Richard B, Banks, Stuart, Bruckner, Andrew, Chiriboga, Angel, Cortés, Jorge, Delbeek, J. Charles, DeVantier, Lyndon, Edgar, Graham J, Edwards, Alasdair J, Fenner, Douglas, Guzmán, Héctor M, Hoeksema, Bert W, Hodgson, Gregor, Johan, Ofri, Licuanan, Wilfredo Y, Livingstone, Suzanne R, Lovell, Edward R, Moore, Jennifer A, Obura, David O, Ochavillo, Domingo, Polidoro, Beth A, Precht, William F, Quibilan, Miledel C, Reboton, Clarissa, Richards, Zoe T, Rogers, Alex D, Sanciangco, Jonnell, Sheppard, Anne, Sheppard, Charles, Smith, Jennifer, Stuart, Simon, Turak, Emre, Veron, John E.N, Wallace, Carden, Weil, Ernesto, Wood, Elizabeth

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 by Curran, Martin D., Roy, Sunando, Shaaban, Sharif, de Cesare, Mariateresa, Stark, Richard, Palmer, Steve, Jeffries, Aaron R., da Silva Filipe, Ana, Davis, Thomas, Collins, Jennifer, Williams, Thomas, Haldenby, Sam T., Cook, Kate, Davies, Robert, Kay, Sally, Poplawski, Radoslaw, Reynolds, Nicola, Moll, Robin J., Thornton, Alicia, Gatica-Wilcox, Bree, Louka, Stavroula F., Kraemer, Moritz U.G., Freeman, Timothy M., Abudahab, Khalil, Menegazzo, Mirko, Mason, Jenifer, Holmes, Alison, Curran, Tanya, Mookerjee, Siddharth, Munn, Robert, Davies, Alisha, Smith, Nikki, Cormie, Claire, Lo, Stephanie, Auckland, Cressida, Mollett, Guy, Harper, Katherine L., Bonner, Stephen, Padgett, Debra, Burton-Fanning, Shirelle, Bedford, Luke, Coupland, Lindsay, Wright, Victoria, Ball, Jonathan, Boswell, Tim, Duckworth, Nichola, Williams, Rebecca, Cogger, Benjamin J., Farr, Ben W., Thurston, Scott A.J., Bronner, Iraad F., Aigrain, Louise, Gallagher, Michael D., Miah, Shahjahan, Ramsay, Mary, Schaefer, Ulf, Manesis, Nikos, Allara, Elias, Nichols, Jenna, Vamos, Edith E., Hughes, Margaret, Wilson, Harry D., Wilson, Rebekah E., Thompson, Thomas, O’Brien, Sarah, Rudder, Steven, McCluggage, Kathryn, Bonfield, James, Liddle, Jennifier, Rowe, Will, Bevan, Paul, Clark, Richard, Cutts, Tim, Densem, Aiden, Dodd, David, Griffiths, Coline, Kay, Keely, Lensing, Stefanie, Lewis-Wade, Amanah, Mamun, Irfan, Martin, Matt, McClintock, Jo, Nathwani, Claire, Nicholson, Jon, Patel, Gaurang, Petersen, Arabella, Reynolds, Joe, Rudd, Luke, Sadri, Ramin, Sizer, Dale, Soria, Carmen Diaz, Sousa, Catarina, Squares, Janet, Stickland, Tim, Still, Ian, Symons, Edward, Uphill, James, Van, Philip Jansen, Voak, Paul, Corti, Davide

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The Genome of the Kinetoplastid Parasite, Leishmania major by Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, Sisk, Ellen, Rajandream, Marie-Adele, Adlem, Ellen, Aert, Rita, Anupama, Atashi, Apostolou, Zina, Bason, Nathalie, Bauser, Christopher, Beck, Alfred, Beverley, Stephen M., Bianchettin, Gabriella, Borzym, Katja, Bothe, Gordana, Bruschi, Carlo V., Collins, Matt, Cadag, Eithon, Ciarloni, Laura, Clayton, Christine, Richard M. R. Coulson, Cronin, Ann, Cruz, Angela K., Davies, Robert M., De Gaudenzi, Javier, Dobson, Deborah E., Duesterhoeft, Andreas, Fazelina, Gholam, Fosker, Nigel, Frasch, Alberto Carlos, Fraser, Audrey, Fuchs, Monika, Gabel, Claudia, Goble, Arlette, Goffeau, André, Harris, David, Hertz-Fowler, Christiane, Hilbert, Helmut, Horn, David, Huang, Yiting, Klages, Sven, Knights, Andrew, Kube, Michael, Larke, Natasha, Litvin, Lyudmila, Lord, Angela, Louie, Tin, Marra, Marco, Masuy, David, Matthews, Keith, Michaeli, Shulamit, Mottram, Jeremy C., Müller-Auer, Silke, Munden, Heather, Nelson, Siri, Norbertczak, Halina, Oliver, Karen, O'Neil, Susan, Pentony, Martin, Pohl, Thomas M., Price, Claire, Purnelle, Bénédicte, Quail, Michael A., Rabbinowitsch, Ester, Reinhardt, Richard, Rieger, Michael, Rinta, Joel, Robben, Johan, Robertson, Laura, Ruiz, Jeronimo C., Rutter, Simon, Saunders, David, Schäfer, Melanie, Schein, Jacquie, Schwartz, David C., Seeger, Kathy, Seyler, Amber, Sharp, Sarah, Shin, Heesun, Sivam, Dhileep, Squares, Rob, Squares, Steve, Tosato, Valentina, Vogt, Christy, Volckaert, Guido, Wambutt, Rolf, Warren, Tim, Wedler, Holger, Woodward, John, Zhou, Shiguo, Zimmermann, Wolfgang, Smith, Deborah F., Blackwell, Jenefer M., Stuart, Kenneth D., Barrell, Bart, Myler, Peter J.

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Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children by French, Courtney E., Delon, Isabelle, Dolling, Helen, Sanchis-Juan, Alba, Shamardina, Olga, Mégy, Karyn, Abbs, Stephen, Austin, Topun, Bowdin, Sarah, Branco, Ricardo G., Firth, Helen, Rowitch, David H., Raymond, F. Lucy

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors by Harrison, Justin R, Brand, Stephen, Smith, Victoria, Robinson, David A, Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S, Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C, Stojanovski, Laste, Frearson, Julie A, Brenk, Ruth, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D

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Characterisation of proteins in excretory/secretory products collected from salmon lice, Lepeophtheirus salmonis by Hamilton, Scott, McLean, Kevin, Monaghan, Sean J, McNair, Carol, Inglis, Neil F, McDonald, Hazel, Adams, Sandra, Richards, Randolph, Roy, William, Smith, Patrick, Bron, James, Nisbet, Alasdair J, Knox, David

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Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB by Cleghorn, Laura A. T, Ray, Peter C, Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D, Green, Simon R, Hipskind, Phil, Parish, Tanya, Wyatt, Paul G

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Severe Mental Illness Among Adults with Atopic Eczema or Psoriasis: Population-Based Matched Cohort Studies within UK Primary Care by Adesanya, Elizabeth I, Henderson, Alasdair D, Matthewman, Julian, Bhate, Ketaki, Hayes, Joseph F, Mulick, Amy, Mathur, Rohini, Smith, Catherine, Carreira, Helena, Rathod, Sujit D, Langan, Sinéad M, Mansfield, Kathryn E

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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target by Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K, Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A, Schnappinger, Dirk, Massoudi, Lisa M, Lenaerts, Anne, Robertson, Gregory T, Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C, Read, Kevin D, Encinas, Lourdes, Bates, Robert H, Green, Simon R, Wyatt, Paul G

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Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis by Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Albrecht, Sébastian, Álvarez-Pedraglio, Ana Isabel, Boesche, Markus, Brand, Stephen, Campbell, Lorna, Cantizani-Perez, Juan, Cleghorn, Laura A.T, Copley, Royston C.B, Crouch, Sabrinia D, Daugan, Alain, Drewes, Gerard, Ferrer, Santiago, Ghidelli-Disse, Sonja, Gonzalez, Silvia, Gresham, Stephanie L, Hill, Alan P, Hindley, Sean J, Lowe, Rhiannon M, MacKenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Miguel-Siles, Juan, Nguyen, Van Loc, Norval, Suzanne, Osuna-Cabello, Maria, Woodland, Andrew, Patterson, Stephen, Pena, Imanol, Quesada-Campos, Maria Teresa, Reid, Iain H, Revill, Charlotte, Riley, Jennifer, Ruiz-Gomez, Jose Ramon, Shishikura, Yoko, Simeons, Frederick R.C, Smith, Alasdair, Smith, Victoria C, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Underwood, Tim, Gray, David W, Fiandor, Jose M, Gilbert, Ian H, Wyatt, Paul G, Read, Kevin D, Miles, Timothy J

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Photopatterned Hybrid Supramolecular/Polymer Hydrogels for Controlled Heparin Release and Stem Cell Growth by López‐Acosta, Álvaro, Chivers, Phillip R. A., Piras, Carmen C., Kay, Alasdair G., Genever, Paul G., Smith, David K.

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SNOT‐22 in a control population by Erskine, S.E., Hopkins, C., Clark, A., Anari, S., Kumar, N., Robertson, A., Sunkaraneni, S., Wilson, J.A., Carrie, S., Kara, N., Ray, J., Smith, R., Philpott, C.M., Philpott, Carl, Erskine, Sally, Clark, Allan, Morris, Steve, Hopkins, Claire, Robertson, Alasdair, Ahmed, Shahzada, Kara, Naveed, Carrie, Sean, Sunkaraneni, Vishnu, Ray, Jaydip, Anari, Shahram, Jervis, Paul, Panesaar, Jaan, Farboud, Amir, Kumar, Nirmal, Cathcart, Russell, Almeyda, Robert, Khalil, Hisham, Prinsley, Peter, Mansell, Nicolas, Salam, Mahmoud, Hobson, Jonathan, Woods, Jane, Coombes, Emma

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Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models by Devoy, Anny, Price, Georgia, De Giorgio, Francesca, Bunton-Stasyshyn, Rosie, Thompson, David, Gasco, Samanta, Allan, Alasdair, Codner, Gemma F., Nair, Remya R., Tibbit, Charlotte, McLeod, Ross, Ali, Zeinab, Noda, Judith, Marrero-Gagliardi, Alessandro, Brito-Armas, José M., Williams, Chloe, Öztürk, Muhammet M., Simon, Michelle, O'Neill, Edward, Bryce-Smith, Sam, Harrison, Jackie, Atkins, Gemma, Corrochano, Silvia, Stewart, Michelle, Gilthorpe, Jonathan D., Teboul, Lydia, Acevedo-Arozena, Abraham, Fisher, Elizabeth M.C., Cunningham, Thomas J.

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Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models by Devoy, Anny, Price, Georgia, De Giorgio, Francesca, Bunton-Stasyshyn, Rosie, Thompson, David, Gasco, Samanta, Allan, Alasdair, Codner, Gemma F., Nair, Remya R., Tibbit, Charlotte, McLeod, Ross, Ali, Zeinab, Noda, Judith, Marrero-Gagliardi, Alessandro, Brito-Armas, José M., Williams, Chloe, Öztürk, Muhammet M., Simon, Michelle, O’Neill, Edward, Bryce-Smith, Sam, Harrison, Jackie, Atkins, Gemma, Corrochano, Silvia, Stewart, Michelle, Gilthorpe, Jonathan D., Teboul, Lydia, Acevedo-Arozena, Abraham, Fisher, Elizabeth M.C., Cunningham, Thomas J.

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