Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents by Tian, Xinrong, Switzer, Adrian G, Derose, Steve A, Mishra, Rajesh K, Solinsky, Mark G, Mumin, Rashid N, Ebetino, Frank H, Jayasinghe, Lalith R, Webster, Mark E, Colson, Anny-Odile, Crossdoersen, Doreen, Pinney, Beth B, Farmer, Julie A, Dowty, Martin E, Obringer, Cindy M, Cruze, Charles A, Burklow, Melissa L, Suchanek, Paula M, Dong, Lily, Dirr, Mary Kay, Sheldon, Russell J, Wos, John A

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles by Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles by Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.

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Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists by Tian, Xinrong, Chen, Xuemei, Gan, Lixian, Hayes, Jeffery C., Switzer, Adrian G., Solinsky, Mark G., Ebetino, Frank H., Wos, John A., Pinney, Beth B., Farmer, Julie A., Crossdoersen, Doreen, Sheldon, Russell J.

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Structure-based design of novel groups for use in the PI position of thrombin inhibitor scaffolds. Part 2. N-acetamidoimidazoles by ISAACS, Richard C. A, SOLINSKY, Mark G, YOUWEI YAN, LYNCH, J. J, LYLE, E. A, CUTRONA, Kellie J, NEWTON, Christina L, NAYLOR-OLSEN, Adel M, MC MASTERS, Daniel R, KRUEGER, Julie A, DALE LEWIS, S, LUCAS, Bobby J, KUO, Lawrence C

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part I: Weakly basic azoles by ISAACS, Richard C. A, SOLINSKY, Mark G, CUTRONA, Kellie J, NEWTON, Christina L, NAYLOR-OLSEN, Adel M, KRUEGER, Julie A, LEWIS, S. Dale, LUCAS, Bobby J

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Synthesis of Tic-d-Phe [Psi][CH sub(2)-CH sub(2)] isostere and its use in the development of melanocortin receptor agonists by Tian, Xinrong, Chen, Xuemei, Gan, Lixian, Hayes, Jeffery C, Switzer, Adrian G, Solinsky, Mark G, Ebetino, Frank H, Wos, John A, Pinney, Beth B, Farmer, Julie A, Crossdoersen, Doreen, Sheldon, Russell J

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C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption by Isaacs, Richard C.A., Cutrona, Kellie J., Newton, Christina L., Sanderson, Philip E.J., Solinsky, Mark G., Baskin, Elizabeth P., Chen, I-Wu, Cooper, Carolyn M., Cook, Jacquelynn J., Gardell, Stephen J., Lewis, S.Dale, Lucas, Robert J., Lyle, Elizabeth A., Lynch, Joseph J., Naylor-Olsen, Adel M., Stranieri, Maria T., Vastag, Kari, Vacca, Joseph P.

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