PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent by Staples, Jeffrey, Qiao, Dandi, Cho, Michael H., Silverman, Edwin K., Nickerson, Deborah A., Below, Jennifer E.

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Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease by Horowitz, Julie E., Warner, Neil, Staples, Jeffrey, Crowley, Eileen, Gosalia, Nehal, Murchie, Ryan, Van Hout, Cristopher, Fiedler, Karoline, Welch, Gabriel, King, Alejandra Klauer, Reid, Jeffrey G., Overton, John D., Baras, Aris, Shuldiner, Alan R., Griffiths, Anne, Gottesman, Omri, Muise, Aleixo M., Gonzaga-Jauregui, Claudia

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Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies by Cavazos, Taylor B, Kachuri, Linda, Graff, Rebecca E, Nierenberg, Jovia L, Thai, Khanh K, Alexeeff, Stacey, Van Den Eeden, Stephen, Corley, Douglas A, Kushi, Lawrence H, Hoffmann, Thomas J, Ziv, Elad, Habel, Laurel A, Jorgenson, Eric, Sakoda, Lori C, Witte, John S

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Utilizing Graph Theory to Select the Largest Set of Unrelated Individuals for Genetic Analysis by Staples, Jeffrey, Nickerson, Deborah A., Below, Jennifer E.

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Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions by Xiao, Brenda, Velez Edwards, Digna R, Lucas, Anastasia, Drivas, Theodore, Gray, Kathryn, Keating, Brendan, Weng, Chunhua, Jarvik, Gail P, Hakonarson, Hakon, Kottyan, Leah, Elhadad, Noemie, Wei, Wei-Qi, Luo, Yuan, Kim, Dokyoon, Ritchie, Marylyn, Verma, Shefali Setia

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Secondary findings and carrier test frequencies in a large multiethnic sample by Gambin, Tomasz, Jhangiani, Shalini N, Below, Jennifer E, Campbell, Ian M, Wiszniewski, Wojciech, Muzny, Donna M, Staples, Jeffrey, Morrison, Alanna C, Bainbridge, Matthew N, Penney, Samantha, McGuire, Amy L, Gibbs, Richard A, Lupski, James R, Boerwinkle, Eric

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A recurring NFS1 pathogenic variant causes a mitochondrial disorder with variable intra-familial patient outcomes by Hershkovitz, Tova, Kurolap, Alina, Tal, Galit, Paperna, Tamar, Mory, Adi, Staples, Jeffrey, Brigatti, Karlla W., Gonzaga-Jauregui, Claudia, Dumin, Elena, Saada, Ann, Mandel, Hanna, Baris Feldman, Hagit

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Genome-wide survey of parent-of-origin-specific associations across clinical traits derived from electronic health records by Kim, Hye In, Ye, Bin, Staples, Jeffrey, Marcketta, Anthony, Gao, Chuan, Shuldiner, Alan R., Van Hout, Cristopher V.

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank by Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure by Henry, Albert, Roselli, Carolina, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Morley, Michael P., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Backman, Joshua D., Biggs, Mary L., Brandimarto, Jeffrey, Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xu, Chung, Jonathan, Cook, James P., Delgado, Graciela E., Denaxas, Spiros, Dörr, Marcus, Dudley, Samuel C., Esko, Tõnu, Finan, Chris, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Gutmann, Rebecca, Haggerty, Christopher M., Hyde, Craig L., Ingelsson, Erik, Jukema, J. Wouter, Kavousi, Maryam, Khaw, Kay-Tee, Kleber, Marcus E., Køber, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, Lotta, Luca A., Luan, Jian’an, März, Winfried, Melander, Olle, Mordi, Ify R., Morgan, Thomas, Morris, Andrew D., Morris, Andrew P., Morrison, Alanna C., Nelson, Christopher P., Niessner, Alexander, Niiranen, Teemu, O’Donoghue, Michelle L., Owens, Anjali T., Parry, Helen M., Perola, Markus, Rice, Kenneth M., Ridker, Paul M., Rotter, Jerome I., Salo, Perttu, Salomaa, Veikko, Smelser, Diane T., Stender, Steen, Stott, David J., Tammesoo, Mari-Liis, Taylor, Kent D., Teder-Laving, Maris, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Trompet, Stella, Tyl, Benoit, Uitterlinden, Andre G., Veluchamy, Abirami, Völker, Uwe, Voors, Adriaan A., Wareham, Nicholas J., Waterworth, Dawn, Weiss, Raul, Wiggins, Kerri L., Yerges-Armstrong, Laura M., Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, McMurray, John J. V., Yang, Jian, Visscher, Peter M., Malarstig, Anders, Holm, Hilma, Sattar, Naveed, Holmes, Michael V., Cappola, Thomas P., Hingorani, Aroon D., Kuchenbaecker, Karoline, Ellinor, Patrick T., Smith, J. Gustav, Vasan, Ramachandran S., Swerdlow, Daniel I., Lumbers, R. Thomas

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations by Boer, Cindy G., Hatzikotoulas, Konstantinos, Southam, Lorraine, Zhang, Yanfei, Coutinho de Almeida, Rodrigo, Wu, Tian T., Zheng, Jie, Hartley, April, Teder-Laving, Maris, Terao, Chikashi, Zengini, Eleni, Alexiadis, George, Bjornsdottir, Gyda, Gilly, Arthur, Ingvarsson, Thorvaldur, Luetge, Almut, Lund, Sigrun H., Mangino, Massimo, Takuwa, Hiroshi, Thomas, Laurent F., Loughlin, John, Arden, Nigel, Doherty, Michael, Ollier, William E.R., Spector, Tim D., Wallis, Gillian A., Martinsen, Amy E., Fors, Egil Andreas, Hagen, Knut, Nilsen, Kristian Bernhard, Lie, Marie Udnesseter, Børte, Sigrid, Brumpton, Ben, Fritsche, Lars G., Zhou, Wei, Heuch, Ingrid, Storheim, Kjersti, Tyrpenou, Evangelos, Koukakis, Athanasios, Efstathios, Chronopoulos, Nikolaou, Vasileios S., Malizos, Konstantinos, Anastasopoulou, Lydia, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Lotta, Luca A., Shuldiner, Alan, Karalis, Katia, Siminovitch, Katherine, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Padilla, Maria Sotiropoulos, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Bai, Xiaodong, Balasubramanian, Suganthi, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Maxwell, Evan K., Orelus, Max, Panea, Razvan, Polanco, Tommy, Salerno, William, Staples, Jeffrey C., Li, Dadong, Sharma, Deepika, Banerjee, Ilanjana, Locke, Adam, Haas, Mary, Akbari, Parsa, Ferreira, Manuel A.R., Jones, Marcus B., Mitnaul, Lyndon J., Babis, George C., Cheung, Jason Pui Yin, Kang, Jae Hee, Lietman, Steven A., Samartzis, Dino, Stefansson, Kari, Uitterlinden, André G., Davey Smith, George, Valdes, Ana M., Tsezou, Aspasia, Cheah, Kathryn S.E., Hveem, Kristian, Wilkinson, J. Mark, Meulenbelt, Ingrid, Lee, Ming Ta Michael, van Meurs, Joyce B.J., Styrkársdóttir, Unnur, Zeggini, Eleftheria

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ALG9 Mutation Carriers Develop Kidney and Liver Cysts by Besse, Whitney, Chang, Alex R, Luo, Jonathan Z, Triffo, William J, Moore, Bryn S, Gulati, Ashima, Hartzel, Dustin N, Mane, Shrikant, Torres, Vicente E, Somlo, Stefan, Mirshahi, Tooraj

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Phylogenetics applied to genotype/phenotype association and selection analyses with sequence data from angptl4 in humans by Maxwell, Taylor J, Bendall, Matthew L, Staples, Jeffrey, Jarvis, Todd, Crandall, Keith A

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MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk by Surakka, Ida, Fritsche, Lars G., Zhou, Wei, Backman, Joshua, Kosmicki, Jack A., Lu, Haocheng, Brumpton, Ben, Nielsen, Jonas B., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Graham, Sarah E., Chen, Y. Eugene, Lee, Seunggeun, Kang, Hyun Min, Langhammer, Arnulf, Forsmo, Siri, Åsvold, Bjørn O., Styrkarsdottir, Unnur, Holm, Hilma, Gudbjartsson, Daniel, Stefansson, Kari, Baras, Aris, Abecasis, Goncalo R., Hveem, Kristian, Willer, Cristen J.

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Genotyping, sequencing and analysis of 140,000 adults from Mexico City by Ziyatdinov, Andrey, Torres, Jason, Alegre-Díaz, Jesús, Backman, Joshua, Mbatchou, Joelle, Turner, Michael, Gaynor, Sheila M., Joseph, Tyler, Zou, Yuxin, Liu, Daren, Wade, Rachel, Staples, Jeffrey, Panea, Razvan, Popov, Alex, Bai, Xiaodong, Balasubramanian, Suganthi, Habegger, Lukas, Lanche, Rouel, Lopez, Alex, Maxwell, Evan, Jones, Marcus, García-Ortiz, Humberto, Ramirez-Reyes, Raul, Santacruz-Benítez, Rogelio, Nag, Abhishek, Smith, Katherine R., Damask, Amy, Lin, Nan, Paulding, Charles, Reppell, Mark, Zöllner, Sebastian, Jorgenson, Eric, Salerno, William, Petrovski, Slavé, Overton, John, Reid, Jeffrey, Thornton, Timothy A., Abecasis, Gonçalo, Berumen, Jaime, Orozco-Orozco, Lorena, Collins, Rory, Baras, Aris, Hill, Michael R., Emberson, Jonathan R., Marchini, Jonathan, Kuri-Morales, Pablo, Tapia-Conyer, Roberto

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GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms by Ward, Lucas D., Tu, Ho-Chou, Quenneville, Chelsea B., Tsour, Shira, Flynn-Carroll, Alexander O., Parker, Margaret M., Deaton, Aimee M., Haslett, Patrick A. J., Lotta, Luca A., Verweij, Niek, Ferreira, Manuel A. R., Baras, Aris, Hinkle, Gregory, Nioi, Paul

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Profiling and Leveraging Relatedness in a Precision Medicine Cohort of 92,455 Exomes by Staples, Jeffrey, Maxwell, Evan K., Gosalia, Nehal, Gonzaga-Jauregui, Claudia, Snyder, Christopher, Hawes, Alicia, Penn, John, Ulloa, Ricardo, Bai, Xiaodong, Lopez, Alexander E., Van Hout, Cristopher V., O’Dushlaine, Colm, Teslovich, Tanya M., McCarthy, Shane E., Balasubramanian, Suganthi, Kirchner, H. Lester, Leader, Joseph B., Murray, Michael F., Ledbetter, David H., Shuldiner, Alan R., Yancoupolos, George D., Dewey, Frederick E., Carey, David J., Overton, John D., Baras, Aris, Habegger, Lukas, Reid, Jeffrey G.

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Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals by Kember, Rachel L., Merikangas, Alison K., Verma, Shefali S., Verma, Anurag, Judy, Renae, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hahn, Young, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Yadav, Ashish, Jones, Marcus B., Mitnaul, Lyndon J., Damrauer, Scott M., Ritchie, Marylyn D., Rader, Daniel J., Bućan, Maja

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Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes by Deaton, Aimee M., Parker, Margaret M., Ward, Lucas D., Flynn-Carroll, Alexander O., BonDurant, Lucas, Hinkle, Gregory, Akbari, Parsa, Lotta, Luca A., Baras, Aris, Nioi, Paul

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Human Y Chromosome Haplogroup N: A Non-trivial Time-Resolved Phylogeography that Cuts across Language Families by Ilumäe, Anne-Mai, Reidla, Maere, Chukhryaeva, Marina, Järve, Mari, Post, Helen, Karmin, Monika, Saag, Lauri, Agdzhoyan, Anastasiya, Kushniarevich, Alena, Litvinov, Sergey, Ekomasova, Natalya, Tambets, Kristiina, Metspalu, Ene, Khusainova, Rita, Yunusbayev, Bayazit, Khusnutdinova, Elza K., Osipova, Ludmila P., Fedorova, Sardana, Utevska, Olga, Koshel, Sergey, Balanovska, Elena, Behar, Doron M., Balanovsky, Oleg, Kivisild, Toomas, Underhill, Peter A., Villems, Richard, Rootsi, Siiri

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