Tracking genomic cancer evolution for precision medicine: the lung TRACERx study by Jamal-Hanjani, Mariam, Hackshaw, Alan, Ngai, Yenting, Shaw, Jacqueline, Dive, Caroline, Quezada, Sergio, Middleton, Gary, de Bruin, Elza, Le Quesne, John, Shafi, Seema, Falzon, Mary, Horswell, Stuart, Blackhall, Fiona, Khan, Iftekhar, Janes, Sam, Nicolson, Marianne, Lawrence, David, Forster, Martin, Fennell, Dean, Lee, Siow-Ming, Lester, Jason, Kerr, Keith, Muller, Salli, Iles, Natasha, Smith, Sean, Murugaesu, Nirupa, Mitter, Richard, Salm, Max, Stuart, Aengus, Matthews, Nik, Adams, Haydn, Ahmad, Tanya, Attanoos, Richard, Bennett, Jonathan, Birkbak, Nicolai Juul, Booton, Richard, Brady, Ged, Buchan, Keith, Capitano, Arrigo, Chetty, Mahendran, Cobbold, Mark, Crosbie, Philip, Davies, Helen, Denison, Alan, Djearman, Madhav, Goldman, Jacki, Haswell, Tom, Joseph, Leena, Kornaszewska, Malgorzata, Krebs, Matthew, Langman, Gerald, MacKenzie, Mairead, Millar, Joy, Morgan, Bruno, Naidu, Babu, Nonaka, Daisuke, Peggs, Karl, Pritchard, Catrin, Remmen, Hardy, Rowan, Andrew, Shah, Rajesh, Smith, Elaine, Summers, Yvonne, Taylor, Magali, Veeriah, Selvaraju, Waller, David, Wilcox, Ben, Wilcox, Maggie, Woolhouse, Ian, McGranahan, Nicholas, Swanton, Charles

Get full text

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study: e1001906 by Jamal-Hanjani, Mariam, Hackshaw, Alan, Ngai, Yenting, Shaw, Jacqueline, Dive, Caroline, Quezada, Sergio, Middleton, Gary, Bruin, Elza de, Quesne, John Le, Shafi, Seema, Falzon, Mary, Horswell, Stuart, Blackhall, Fiona, Khan, Iftekhar, Janes, Sam, Nicolson, Marianne, Lawrence, David, ster, Martin, Fennell, Dean, Lee, Siow-Ming, Lester, Jason, Kerr, Keith, Muller, Salli, Iles, Natasha, Smith, Sean, Murugaesu, Nirupa, Mitter, Richard, Salm, Max, Stuart, Aengus, Matthews, Nik, Adams, Haydn, Ahmad, Tanya, Attanoos, Richard, Bennett, Jonathan, Birkbak, Nicolai Juul, Booton, Richard, Brady, Ged, Buchan, Keith, Capitano, Arrigo, Chetty, Mahendran, Cobbold, Mark, Crosbie, Philip, Davies, Helen, Denison, Alan, Djearman, Madhav, Goldman, Jacki, Haswell, Tom, Joseph, Leena, Kornaszewska, Malgorzata, Krebs, Matthew, Langman, Gerald, MacKenzie, Mairead, Millar, Joy, Morgan, Bruno, Naidu, Babu, Nonaka, Daisuke, Peggs, Karl, Pritchard, Catrin, Remmen, Hardy, Rowan, Andrew, Shah, Rajesh, Smith, Elaine, Summers, Yvonne, Taylor, Magali, Veeriah, Selvaraju, Waller, David, Wilcox, Ben, Wilcox, Maggie, Woolhouse, Ian, McGranahan, Nicholas, Swanton, Charles

Get full text

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts by Esnault, Cyril, Stewart, Aengus, Gualdrini, Francesco, East, Phil, Horswell, Stuart, Matthews, Nik, Treisman, Richard

Get full text

SRF Co-factors Control the Balance between Cell Proliferation and Contractility by Gualdrini, Francesco, Esnault, Cyril, Horswell, Stuart, Stewart, Aengus, Matthews, Nik, Treisman, Richard

Get full text

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer by López-García, Carlos, Sansregret, Laurent, Domingo, Enric, McGranahan, Nicholas, Hobor, Sebastijan, Birkbak, Nicolai Juul, Horswell, Stuart, Grönroos, Eva, Favero, Francesco, Rowan, Andrew J., Matthews, Nicholas, Begum, Sharmin, Phillimore, Benjamin, Burrell, Rebecca, Oukrif, Dahmane, Spencer-Dene, Bradley, Kovac, Michal, Stamp, Gordon, Stewart, Aengus, Danielsen, Havard, Novelli, Marco, Tomlinson, Ian, Swanton, Charles

Get full text

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal by Mitchell, Thomas J., Turajlic, Samra, Rowan, Andrew, Nicol, David, Farmery, James H.R., O’Brien, Tim, Martincorena, Inigo, Tarpey, Patrick, Angelopoulos, Nicos, Yates, Lucy R., Butler, Adam P., Raine, Keiran, Stewart, Grant D., Challacombe, Ben, Fernando, Archana, Lopez, Jose I., Hazell, Steve, Chandra, Ashish, Chowdhury, Simon, Rudman, Sarah, Soultati, Aspasia, Stamp, Gordon, Fotiadis, Nicos, Pickering, Lisa, Au, Lewis, Spain, Lavinia, Lynch, Joanna, Stares, Mark, Teague, Jon, Maura, Francesco, Wedge, David C., Horswell, Stuart, Chambers, Tim, Litchfield, Kevin, Xu, Hang, Stewart, Aengus, Elaidi, Reza, Oudard, Stéphane, McGranahan, Nicholas, Csabai, Istvan, Gore, Martin, Futreal, P. Andrew, Larkin, James, Lynch, Andy G., Szallasi, Zoltan, Swanton, Charles, Campbell, Peter J.

Get full text

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution by Hiley, Crispin T., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Herrero, Javier, Swanton, Charles, Swanton, Charles, Czyzewska-Khan, Justyna, Gorman, Pat, Wilson, Gareth, Watkins, Thomas B.K., McGranahan, Nicholas, Mitter, Richard, Escudero, Mickael, Rowan, Andrew, Xu, Hang, Turajlic, Samra, Stone, Richard Kevin, Denner, Tamara, Costa, Marta, Phillimore, Ben, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Quezada, Sergio, Hartley, John A., Lowe, Helen L., Herrero, Javier, Lawrence, David, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Janes, Sam M., Thakrar, Ricky, Papadatos-Pastos, Dionysis, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturved, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Blackhall, Fiona, Chemi, Francesca, Gulati, Sakshi, Naidu, Babu, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Middleton, Gary, Shaw, Jacqui A., Le Quesne, John, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Riley, Joan, Primrose, Lindsay, Anand, Girija, Nicolson, Marianne, Palmer, Shirley, Buchan, Keith, Chetty, Mahendran, Edwards, Alison, Morgan, Fiona, Davies, Helen, Verjee, Azmina, MacKenzie, Mairead, Hackshaw, Allan, Smith, Sean, Alzetani, Aiman, Shaw, Emily, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Bhayani, Harshil, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-sellers, Melanie, Prakash, Vineet, Horey, Tracey, Hill, Jennifer, Suvarna, Kim, Keerio, Allah Dino, Feeney, Sarah, Asante-Siaw, Julius, Dessimoz, Christophe

Get full text

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution by de Bruin, Elza C., McGranahan, Nicholas, Mitter, Richard, Salm, Max, Wedge, David C., Yates, Lucy, Jamal-Hanjani, Mariam, Shafi, Seema, Murugaesu, Nirupa, Rowan, Andrew J., Grönroos, Eva, Muhammad, Madiha A., Horswell, Stuart, Gerlinger, Marco, Varela, Ignacio, Jones, David, Marshall, John, Voet, Thierry, Van Loo, Peter, Rassl, Doris M., Rintoul, Robert C., Janes, Sam M., Lee, Siow-Ming, Forster, Martin, Ahmad, Tanya, Lawrence, David, Falzon, Mary, Capitanio, Arrigo, Harkins, Timothy T., Lee, Clarence C., Tom, Warren, Teefe, Enock, Chen, Shann-Ching, Begum, Sharmin, Rabinowitz, Adam, Phillimore, Benjamin, Spencer-Dene, Bradley, Stamp, Gordon, Szallasi, Zoltan, Matthews, Nik, Stewart, Aengus, Campbell, Peter, Swanton, Charles

Get full text

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal by Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I., Nicol, David, O’Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas B.K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles

Get full text

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal by Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O’Brien, Tim, Lopez, Jose I., Watkins, Thomas B.K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles

Get full text

ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription by Esnault, Cyril, Gualdrini, Francesco, Horswell, Stuart, Kelly, Gavin, Stewart, Aengus, East, Phil, Matthews, Nik, Treisman, Richard

Get full text

Antibodies against endogenous retroviruses promote lung cancer immunotherapy by Ng, Kevin W., Boumelha, Jesse, Enfield, Katey S. S., Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A., Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T. C., Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R. M., Watkins, Thomas B. K., Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M., Al Bakir, Maise, Lim, Emilia L., Hill, Mark S., Wilson, Gareth A., Cook, Daniel E., Birkbak, Nicolai J., Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T., Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

Get full text

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors by Lesko, Marta H., Miranda Rota, Enrique, Dahan, Rony, Georgiou, Andrew, Sledzinska, Anna, Werner Sunderland, Mariana, Nicol, David, Beers, Stephen A., Wotherspoon, Andrew, Hayes, Andrew, Stares, Mark, Pickering, Lisa, Rudman, Sarah, Veeriah, Selvaraju, Shafi, Seema, Laycock, Joanne, Bosshard-Carter, Leticia, Goh, Gerald, Rosenthal, Rachel, Hynds, Robert E., Birkbak, Nicolai J., McGranahan, Nicholas, Mitter, Richard, Stewart, Aengus, Rowan, Andrew, Turajlic, Samra, Abbosh, Christopher, Goldman, Jacki, Denner, Tamara, Ward, Sophia, Costa, Marta, Lowe, Helen L., Lawrence, David, Kolvekar, Shyam, Falzon, Mary, Simeon, Celia, Hector, Gemma, Novelli, Marco, Forster, Martin, Papadatos-Pastos, Dionysis, Carnell, Dawn, Navani, Neal, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Taylor, Paul, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Moss, Stuart, Idries, Faiza, Joseph, Leena, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Blackhall, Fiona, Rogan, Jane, Tugwood, Jonathan, Rothwell, Dominic G., Pierce, Jackie, Gulati, Sakshi, Kerr, Amy, Webb, Joanne, Moore, David, Monteiro, William, Marshall, Hilary, Nelson, Louise, Amadi, Anita, Remmen, Hardy, Miller, Joy, Morgan, Fiona, Kornaszewska, Malgorzata, Bell, Harriet, Smith, Sean, Johnson, Benjamin, Lim, Eric, Barbosa, Monica Tavares, Bowman, Alex, Ronquillo, John Carlo, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Buderi, Silviu, Finch, Jonathan, Green, Sophie, Nicholson, Andrew G., Lau, Kelvin, Schmid, Peter, Conibear, John, Ezhil, Veni, Ismail, Babikir, Prakash, Vineet, Horey, Tracey, Swanton, Charles, Chester, Kerry A., Ravetch, Jeffrey V., Marafioti, Teresa, Peggs, Karl S., Quezada, Sergio A.

Get full text

Mutation of cancer driver MLL2 results in transcription stress and genome instability by Kantidakis, Theodoros, Saponaro, Marco, Mitter, Richard, Horswell, Stuart, Kranz, Andrea, Boeing, Stefan, Aygün, Ozan, Kelly, Gavin P, Matthews, Nik, Stewart, Aengus, Stewart, A Francis, Svejstrup, Jesper Q

Get full text

TCT CONNECT-28 Left Ventricular End-Diastolic Pressure in Acute Myocardial Infarction, Association With Infarct Pathology, Left Ventricular Function, and Health Outcomes by McCartney, Peter, Maznyczka, Annette, McEntegart, Margaret, Eteiba, Hany, Greenwood, John, Muir, Douglas, Chowdhary, Saqib, Gershlick, Anthony, Appleby, Clare, Cotton, James, Wragg, Andrew, Curzen, Nick, Oldroyd, Keith, Lindsay, Mitchell, Rocchiccioli, Paul, Shaukat, Aadil, Good, Richard, Watkins, Stuart, Robertson, Keith, Malkin, Christopher John, Collison, Damien, Gillespie, Lynsey, Martin, Lynn, Ford, Tom, Petrie, Mark, Weir, Robin, Murphy, Aengus, Petrie, Colin, Wetherall, Kirsty, Macfarlane, Peter, McConnachie, Alex, Berry, Colin

Get full text

Near real-time geoprocessing on the grid: A scalable approach to road traffic monitoring by McCullough, Aengus, James, Philip, Barr, Stuart

Get full text

Mutation of cancer driver MLL2 results in transcription stress and genome instability by Kantidakis, Theodoros, Saponaro, Marco, Mitter, Richard, Horswell, Stuart, Kranz, Andrea, Boeing, Stefan, Aygun, Ozan, Kelly, Gavin P, Matthews, Nik, Stewart, Aengus, Stewart, A Francis, Svejstrup, Jesper Q

Get full text

A Service Oriented Geoprocessing System for Real-Time Road Traffic Monitoring by McCullough, Aengus, James, Philip, Barr, Stuart

Get full text

Abstract 983: Intratumor heterogeneity in non-small cell lung cancer inferred by multi-region exome sequencing by Bruin, Elza D., McGranahan, Nicholas, Yates, Lucy, Jamal-Hanjani, Mariam, Salm, Max, Mitter, Richard, Shafi, Seema, Murugaesu, Nirupa, Rowan, Andrew, Gerlinger, Marco, Wedge, David, Horswell, Stuart, Varela, Ignacio, Tom, Warren, Parikh, Chaitali, Harkins, Timothy, Lee, Clarence, Matthews, Nik, Stewart, Aengus, Campbell, Peter, Swanton, Charles

Get full text

Abstract 4603: Intratumor heterogeneity in clear cell renal cell carcinoma (ccRCC): Multi-region sequencing redefines the mutational landscape of ccRCCs by Gerlinger, Marco, Horswell, Stuart, Larkin, James, Rowan, Andrew J., Martinez, Pierre, Varela, Ignacio, Santos, Claudio R., Fisher, Rosalie, Salm, Max P., Szallasi, Zoltan, Matthews, Nicholas, Stewart, Aengus, Futreal, P Andrew, Swanton, Charles

Get full text