Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor by CHAMBERS, Laura J, STEVENS, Alexander J, THEOBALD, Pam J, BESWICK, Paul J, GLEAVE, Robert J, ROMAN, Shilina A, SENGER, Stefan, MOSES, Andrew P, MICHEL, Anton D, WALTER, Daryl S, DAVIES, David J, LIVERMORE, David G, FONFRIA, Elena, DEMONT, Emmanuel H, VIMAL, Mythily

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Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X sub(7) receptor by Chambers, Laura J, Stevens, Alexander J, Moses, Andrew P, Michel, Anton D, Walter, Daryl S, Davies, David J, Livermore, David G, Fonfria, Elena, Demont, Emmanuel H, Vimal, Mythily, Theobald, Pam J, Beswick, Paul J, Gleave, Robert J, Roman, Shilina A, Senger, Stefan

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Synthesis and structure–activity relationships of a series of (1 H-pyrazol-4-yl)acetamide antagonists of the P2X 7 receptor by Chambers, Laura J., Stevens, Alexander J., Moses, Andrew P., Michel, Anton D., Walter, Daryl S., Davies, David J., Livermore, David G., Fonfria, Elena, Demont, Emmanuel H., Vimal, Mythily, Theobald, Pam J., Beswick, Paul J., Gleave, Robert J., Roman, Shilina A., Senger, Stefan

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs) by Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, East, Philip, Hawkins, Julie, Howes, Colin, Hussain, Ishrut, Jeffrey, Phil, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S, Wayne, Gareth

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent by Charrier, Nicolas, Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character by Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells by Beswick, Paul, Charrier, Nicolas, Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Gleave, Robert, Hawkins, Julie, Hussain, Ishrut, Johnson, Christopher N., MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Skidmore, John, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Stuart, Alistair, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing... by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296 by Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing eff... by SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

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