Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability by Grillot, Anne-Laure, Tiran, Arnaud Le, Shannon, Dean, Krueger, Elaine, Liao, Yusheng, O’Dowd, Hardwin, Tang, Qing, Ronkin, Steve, Wang, Tiansheng, Waal, Nathan, Li, Pan, Lauffer, David, Sizensky, Emmanuelle, Tanoury, Jerry, Perola, Emanuele, Grossman, Trudy H, Doyle, Tim, Hanzelka, Brian, Jones, Steven, Dixit, Vaishali, Ewing, Nigel, Liao, Shengkai, Boucher, Brian, Jacobs, Marc, Bennani, Youssef, Charifson, Paul S

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of M... by Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M

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Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax by Tiran, Arnaud Le, Claperon, Audrey, Davidson, James, Starck, Jérôme-Benoit, Diguarher, Thierry Le, Chanrion, Maïa, Mistry, Prakash, Wang, Youzhen, Monceau, Elodie, Bernhardt, Fabienne, Rocchetti, Francesca, Lysiak-Auvity, Gaelle, Chen, Ijen, Daniels, Zoe, Pedder, Chris, Fallowfield, Mandy, Henlin, Jean-Michel, Fejes, Imre, Tatai, Janos, Nyerges, Miklos, Durand, Didier, Zarka, Marion, Sanghavi, Sneha, Girard, Anne-Marie, Schoumacher, Marie, Kraus-Berthier, Laurence, Newcombe, Rick, Halilovic, Ensar, Banquet, Sébastien, Rupin, Alain, Maacke, Heiko, Murray, James, Morris, Erick, Hofmann, Francesco, Colland, Frédéric, Geneste, Olivier

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Design and synthesis of bridged piperidine and piperazine isosteres by Maertens, Gaëtan, Saavedra, Oscar M., Vece, Vito, Reyes, Miguel A. Vilchis, Hocine, Sofiane, Öney, Esat, Goument, Bertrand, Mirguet, Olivier, Le Tiran, Arnaud, Gloanec, Philippe, Hanessian, Stephen

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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ by Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.

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Synthesis of a 6‑Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3‑Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization by Collier, Philip N, Panchagnula, Advaita, O’Dowd, Hardwin, Le Tiran, Arnaud, Aronov, Alex M

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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV by O’Dowd, Hardwin, Shannon, Dean E, Chandupatla, Kishan R, Dixit, Vaishali, Engtrakul, Juntyma J, Ye, Zhengqi, Jones, Steven M, O’Brien, Colleen F, Nicolau, David P, Tessier, Pamela R, Crandon, Jared L, Song, Bin, Macikenas, Dainius, Hanzelka, Brian L, Le Tiran, Arnaud, Bennani, Youssef L, Charifson, Paul S, Grillot, Anne-Laure

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