Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression by Tolar, Martin, Hey, John, Power, Aidan, Abushakra, Susan

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Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval by Tolar, Martin, Abushakra, Susan, Hey, John A., Porsteinsson, Anton, Sabbagh, Marwan

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The Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention by Tolar, Martin, Hey, John A, Power, Aidan, Abushakra, Susan

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APOLLOE4 Phase 3 study of oral ALZ‐801/valiltramiprosate in APOE ε4/ε4 homozygotes with early Alzheimer's disease: Trial design and baseline characteristics by Abushakra, Susan, Porsteinsson, Anton P., Sabbagh, Marwan, Watson, David, Power, Aidan, Liang, Earvin, MacSweeney, Emer, Boada, Merce, Flint, Susan, McLaine, Rosalind, Kesslak, J. Patrick, Hey, John A., Tolar, Martin

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APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline by Abushakra, Susan, Porsteinsson, Anton P., Sabbagh, Marwan, Bracoud, Luc, Schaerer, Joel, Power, Aidan, Hey, John A., Scott, David, Suhy, Joyce, Tolar, Martin

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Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data by Kocis, Petr, Tolar, Martin, Yu, Jeremy, Sinko, William, Ray, Soumya, Blennow, Kaj, Fillit, Howard, Hey, John A.

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Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer’s Disease by Hey, John A., Yu, Jeremy Y., Versavel, Mark, Abushakra, Susan, Kocis, Petr, Power, Aidan, Kaplan, Paul L., Amedio, John, Tolar, Martin

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Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain by Hey, John A., Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y., Tolar, Martin

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Analysis of Cerebrospinal Fluid, Plasma β-Amyloid Biomarkers, and Cognition from a 2-Year Phase 2 Trial Evaluating Oral ALZ-801/Valiltramiprosate in APOE4 Carriers with Early Alzhe... by Hey, John A., Yu, Jeremy Y., Abushakra, Susan, Schaefer, Jean F., Power, Aidan, Kesslak, Patrick, Tolar, Martin

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Breakthroughs in Alzheimer Research Pave Way for New Era of Treatment: Martin Tolar, MD, PhD by Tolar, Martin

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Effects of Oral ALZ-801/Valiltramiprosate on Plasma Biomarkers, Brain Hippocampal Volume, and Cognition: Results of 2-Year Single-Arm, Open-Label, Phase 2 Trial in APOE4 Carriers w... by Hey, John A., Abushakra, Susan, Blennow, Kaj, Reiman, Eric M., Hort, Jakub, Prins, Niels D., Sheardova, Katerina, Kesslak, Patrick, Shen, Larry, Zhu, Xinyi, Albayrak, Adem, Paul, Jijo, Schaefer, Jean F., Power, Aidan, Tolar, Martin

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Spatial navigation testing discriminates two types of amnestic mild cognitive impairment by Laczó, Jan, Vlček, Kamil, Vyhnálek, Martin, Vajnerová, Olga, Ort, Michael, Holmerová, Iva, Tolar, Martin, Andel, Ross, Bojar, Martin, Hort, Jakub

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Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ.801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain by Hey, John A, Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y, Tolar, Martin

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Tramiprosate, an oral amyloid anti-aggregation agent, shows robust cognitive efficacy in APOE4/4 homozygous ad patients: efficacy and safety analyses from two Phase 3 trials by Abushakra, Susan, Vellas, Bruno, Cummings, Jeffrey, Hey, John, Tolar, Martin, Power, Aidan

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Efficacy of tramiprosate in APOE4 heterozygous patients with mild to moderate ad: combined sub-group analyses from two Phase 3 trials by Tolar, Martin, Vellas, Bruno, Cummings, Jeffrey, Porsteinsson, Anton, Abushakra, Susan, Hey, John

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Correction to: Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain by Hey, John A., Kocis, Petr, Hort, Jakub, Abushakra, Susan, Power, Aidan, Vyhnálek, Martin, Yu, Jeremy Y., Tolar, Martin

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Biotech leaders call for free press by Cohen, Ron, Holtzman, Steven, Levin, Jeremy M, Maraganore, John M

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Imaging is superior to cognitive testing for early diagnosis of Alzheimer’s disease by Zamrini, Edward, De Santi, Susan, Tolar, Martin

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US immigration order strikes against biotech by Maraganore, John, Hastings, Paul J, Cohen, Ron, Adams, Julian, Adams, Chris, Aspinall, Mara G, Babler, Martin, Barry, Zoe, Bolno, Paul B, Booth, Bruce, Bradbury, Daniel M, Brauer, Steven K, Cali, Brian M, Ciechanover, Isaac, Clark, Chip, Clayman, Michael D, Cobb, Paula, Cooper, Ron, Currie, Mark G, Dobmeier, Eric L, Doerfler, Doug, Dunsire, Deborah, Flesher, Gregory J, Formela, Jean-Francois, Forrester, Robert, Freeman, Mason W, Furst, Howard, Gage, Leonard Patrick, Gallagher, Brian M, Geraghty, James A, Gill, Simba, Gowen, Maxine, Grayzel, David, Greene, Barry, Grint, Paul, Haney, Bill, Ha-Ngoc, Tuan, Harris, Tim, Hasnain, Faheem, Heyman, Rich, Hoppenot, Herve, Hughes, Thomas E, Hutton, Wende S, Isaacs, Stephen T, Jenkins, Annalisa, Jonker, Jeff, Karsen, Perry, Kindler, Jeff, King, Rachel, Koenig, Scott, Kolchinsky, Peter, Laikind, Paul, Lee, John J, Leicher, Bruce A, Levin, Andrew, Levine, Arnold J, Lopatin, Uri, Maderis, Gail J, Mahadevia, Ankit, McArthur, James G, McCarthy, Sean A, Miralles, Diego, Moch, Kenneth I, More, Bob, Myers, Andrew G, Newell, William J, Olle, Bernat, Osborn, John E, Owens, Julia C, Pande, Atul, Papadopoulos, Stelios, Parmar, Kush M, Patterson, Matthew R, Perez, Rob, Pfeffer, Cary G, Ramamoorthi, Kartik, Rawcliffe, Adrian (Ad), Reid, Laurence E, Renaud, Ron C, Rieflin, William J, Robins, Chad, Rosin, Jonathan G, Rutter, William J, Saha, Saurabh, Samuels, Camille, Sato, Vicki L, Scangos, George, Schreiber, Stuart L, Schwab, Andrew, Simon, Nick J, Taglietti, Marco, Tandon, Nina, Termeer, Henri, Ulevitch, Richard, Vaishnaw, Akshay K, Varsavsky, Martin, Vlasuk, George P, Williams, Doug E, Zohar, Daphne, Zweifach, Sandford (Sandy)

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The Future of Anti-Amyloid Trials by Aisen, P. S., Cummings, J., Doody, R., Kramer, L., Salloway, S., Selkoe, D. J., Sims, J., Sperling, R. A., Vellas, B.

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