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Search Results - Totoritis, Rachel D.
Search Results - Totoritis, Rachel D.
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
by
Harris, Philip A
,
Marinis, Jill M
,
Lich, John D
,
Berger, Scott B
,
Chirala, Anirudh
,
Cox, Julie A
,
Eidam, Patrick M
,
Finger, Joshua N
,
Gough, Peter J
,
Jeong, Jae U
,
Kang, James
,
Kasparcova, Viera
,
Leister, Lara K
,
Mahajan, Mukesh K
,
Miller, George
,
Nagilla, Rakesh
,
Ouellette, Michael T
,
Reilly, Michael A
,
Rendina, Alan R
,
Rivera, Elizabeth J
,
Sun, Helen H
,
Thorpe, James H
,
Totoritis, Rachel D
,
Wang, Wei
,
Wu, Dongling
,
Zhang, Daohua
,
Bertin, John
,
Marquis, Robert W
Published in
ACS medicinal chemistry letters
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2
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
by
Harris, Philip A
,
King, Bryan W
,
Bandyopadhyay, Deepak
,
Berger, Scott B
,
Campobasso, Nino
,
Capriotti, Carol A
,
Cox, Julie A
,
Dare, Lauren
,
Dong, Xiaoyang
,
Finger, Joshua N
,
Grady, LaShadric C
,
Hoffman, Sandra J
,
Jeong, Jae U
,
Kang, James
,
Kasparcova, Viera
,
Lakdawala, Ami S
,
Lehr, Ruth
,
McNulty, Dean E
,
Nagilla, Rakesh
,
Ouellette, Michael T
,
Pao, Christina S
,
Rendina, Alan R
,
Schaeffer, Michelle C
,
Summerfield, Jennifer D
,
Swift, Barbara A
,
Totoritis, Rachel D
,
Ward, Paris
,
Zhang, Aming
,
Zhang, Daohua
,
Marquis, Robert W
,
Bertin, John
,
Gough, Peter J
Published in
Journal of medicinal chemistry
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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase
by
Harris, Philip A
,
Faucher, Nicolas
,
George, Nicolas
,
Eidam, Patrick M
,
King, Bryan W
,
White, Gemma V
,
Anderson, Niall A
,
Bandyopadhyay, Deepak
,
Beal, Allison M
,
Beneton, Veronique
,
Berger, Scott B
,
Campobasso, Nino
,
Campos, Sebastien
,
Capriotti, Carol A
,
Cox, Julie A
,
Daugan, Alain
,
Donche, Frederic
,
Fouchet, Marie-Hélène
,
Finger, Joshua N
,
Geddes, Brad
,
Gough, Peter J
,
Grondin, Pascal
,
Hoffman, Bonnie L
,
Hoffman, Sandra J
,
Hutchinson, Susan E
,
Jeong, Jae U
,
Jigorel, Emilie
,
Lamoureux, Pauline
,
Leister, Lara K
,
Lich, John D
,
Mahajan, Mukesh K
,
Meslamani, Jamel
,
Mosley, Julie E
,
Nagilla, Rakesh
,
Nassau, Pamela M
,
Ng, Sze-Ling
,
Ouellette, Michael T
,
Pasikanti, Kishore K
,
Potvain, Florent
,
Reilly, Michael A
,
Rivera, Elizabeth J
,
Sautet, Stéphane
,
Schaeffer, Michelle C
,
Sehon, Clark A
,
Sun, Helen
,
Thorpe, James H
,
Totoritis, Rachel D
,
Ward, Paris
,
Wellaway, Natalie
,
Wisnoski, David D
,
Woolven, James M
,
Bertin, John
,
Marquis, Robert W
Published in
Journal of medicinal chemistry
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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
by
Harris, Philip A
,
Bandyopadhyay, Deepak
,
Berger, Scott B
,
Campobasso, Nino
,
Capriotti, Carol A
,
Cox, Julie A
,
Dare, Lauren
,
Finger, Joshua N
,
Hoffman, Sandra J
,
Kahler, Kirsten M
,
Lehr, Ruth
,
Lich, John D
,
Nagilla, Rakesh
,
Nolte, Robert T
,
Ouellette, Michael T
,
Pao, Christina S
,
Schaeffer, Michelle C
,
Smallwood, Angela
,
Sun, Helen H
,
Swift, Barbara A
,
Totoritis, Rachel D
,
Ward, Paris
,
Marquis, Robert W
,
Bertin, John
,
Gough, Peter J
Published in
ACS medicinal chemistry letters
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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
by
Haile, Pamela A
,
Casillas, Linda N
,
Bury, Michael J
,
Mehlmann, John F
,
Singhaus, Robert
,
Charnley, Adam K
,
Hughes, Terry V
,
DeMartino, Michael P
,
Wang, Gren Z
,
Romano, Joseph J
,
Dong, Xiaoyang
,
Plotnikov, Nikolay V
,
Lakdawala, Ami S
,
Convery, Maire A
,
Votta, Bartholomew J
,
Lipshutz, David B
,
Desai, Biva M
,
Swift, Barbara
,
Capriotti, Carol A
,
Berger, Scott B
,
Mahajan, Mukesh K
,
Reilly, Michael A
,
Rivera, Elizabeth J
,
Sun, Helen H
,
Nagilla, Rakesh
,
LePage, Carol
,
Ouellette, Michael T
,
Totoritis, Rachel D
,
Donovan, Brian T
,
Brown, Barry S
,
Chaudhary, Khuram W
,
Gough, Peter J
,
Bertin, John
,
Marquis, Robert W
Published in
ACS medicinal chemistry letters
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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
by
Haile, Pamela A.
,
Casillas, Linda N.
,
Bury, Michael J.
,
Mehlmann, John F.
,
Singhaus, Robert
,
Charnley, Adam K.
,
Hughes, Terry V.
,
DeMartino, Michael P.
,
Wang, Gren Z.
,
Romano, Joseph J.
,
Dong, Xiaoyang
,
Plotnikov, Nikolay V.
,
Lakdawala, Ami S.
,
Duraiswami, Chaya
,
Convery, Maire A.
,
Votta, Bartholomew J.
,
Lipshutz, David B.
,
Desai, Biva M.
,
Swift, Barbara
,
Capriotti, Carol A.
,
Berger, Scott B.
,
Mahajan, Mukesh K.
,
Reilly, Michael A.
,
Rivera, Elizabeth J.
,
Sun, Helen H.
,
Nagilla, Rakesh
,
LePage, Carol
,
Ouellette, Michael T.
,
Totoritis, Rachel D.
,
Donovan, Brian T.
,
Brown, Barry S.
,
Chaudhary, Khuram W.
,
Gough, Peter J.
,
Bertin, John
,
Marquis, Robert W.
Published in
ACS medicinal chemistry letters
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7
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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity
by
Charnley, Adam K.
,
Convery, Máire A.
,
Lakdawala Shah, Ami
,
Jones, Emma
,
Hardwicke, Philip
,
Bridges, Angela
,
Ouellette, Michael
,
Totoritis, Rachel
,
Schwartz, Benjamin
,
King, Bryan W.
,
Wisnoski, David D.
,
Kang, James
,
Eidam, Patrick M.
,
Votta, Bartholomew J.
,
Gough, Peter J.
,
Marquis, Robert W.
,
Bertin, John
,
Casillas, Linda
Published in
Bioorganic & medicinal chemistry
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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors
by
Totoritis, Rachel
,
Duraiswami, Chaya
,
Taylor, Amy N
,
Kerrigan, John J
,
Campobasso, Nino
,
Smith, Katherine J
,
Ward, Paris
,
King, Bryan W
,
Murrayz-Thompson, Monique
,
Jones, Amber D
,
Van Aller, Glenn S
,
Aubart, Kelly M
,
Zalacain, Magdalena
,
Thrall, Sara H
,
Meek, Thomas D
,
Schwartz, Benjamin
Published in
Biochemistry (Easton)
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