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Ambroxol increases glucocerebrosidase (GCase) activity and restores GCase translocation in primary patient-derived macrophages in Gaucher disease and Parkinsonism
by
Kopytova, A.E.
,
Rychkov, G.N.
,
Nikolaev, M.A.
,
Baydakova, G.V.
,
Cheblokov, A.A.
,
Senkevich, K.A.
,
Bogdanova, D.A.
,
Bolshakova, O.I.
,
Miliukhina, I.V.
,
Bezrukikh, V.A.
,
Salogub, G.N.
,
Sarantseva, S.V.
,
Usenko, T.C.
,
Zakharova, E.Y.
,
Emelyanov, A.K.
,
Pchelina, S.N.
Published in
Parkinsonism & related disorders
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Journal Title
Parkinsonism & Related Disorders
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Subjects
Adult
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Aged
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Aged, 80 And Over
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Allosteric Binding Site
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Ambroxol
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Ambroxol - Pharmacology
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Binding Free Energy
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Cells, Cultured
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Clinical Neurology
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Enzyme Inhibitors - Pharmacology
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Female
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Gaucher Disease
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Gaucher Disease - Drug Therapy
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Gcase
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Glucosylceramidase - Antagonists & Inhibitors
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Glucosylceramidase - Drug Effects
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Humans
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Life Sciences & Biomedicine
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Macrophages - Drug Effects
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Male
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1400 : 2025
1400
2025
Source
Sciencedirect®
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Sciencedirect Freedom Collection 2022-2024
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