Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument by Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Stachyra-Valat, Thérèse, Ruetz, Stephan, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chène, Patrick, Jeay, Sébastien, Schlapbach, Achim

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Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2 by Stachyra-Valat, Thérèse, Baysang, Frédéric, D’Alessandro, Anne-Cécile, Dirk, Erdmann, Furet, Pascal, Guagnano, Vito, Kallen, Joerg, Leder, Lukas, Mah, Robert, Masuya, Keiichi, Stutz, Stefan, Vaupel, Andrea, Hofmann, Francesco, Chène, Patrick, Jeay, Sébastien, Holzer, Philipp

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors by Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

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Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode by Gessier, François, Kallen, Joerg, Jacoby, Edgar, Chène, Patrick, Stachyra-Valat, Thérèse, Ruetz, Stephan, Jeay, Sébastien, Holzer, Philipp, Masuya, Keiichi, Furet, Pascal

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The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction by Furet, Pascal, Chène, Patrick, De Pover, Alain, Valat, Thérèse Stachyra, Lisztwan, Joanna Hergovich, Kallen, Joerg, Masuya, Keiichi

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Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction by Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

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Abstract 1225: NVP-HDM201: cellular and in vivo profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2 by Jeay, Sébastien, Chène, Patrick, Ferretti, Stéphane, Furet, Pascal, Gruenenfelder, Bjoern, Guagnano, Vito, Guerreiro, Nelson, Halilovic, Ensar, Hofmann, Francesco, Kallen, Joerg, Léonard, Michelle, Mah, Robert, Masuya, Keiichi, Ramos, Rita, Rynn, Caroline, Ruetz, Stephan, Stachyra-Valat, Thérèse, Stutz, Stefan, Vaupel, Andrea, Wuerthner, Jens, Holzer, Philipp

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Corrigendum to “Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction” [Bioorg. Med. Chem. Lett. 24 (9) (2014) 2110–2114] by Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

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Abstract 4855: Discovery of NVP-HDM201 - First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristics by Holzer, Philipp, Chène, Patrick, Ferretti, Stéphane, Furet, Pascal, Gabriel, Tobias, Gruenenfelder, Bjoern, Guagnano, Vito, Hofmann, Francesco, Kallen, Joerg, Mah, Robert, Masuya, Keiichi, Ramos, Rita, Ruetz, Stephan, Rynn, Caroline, Stachyra-Valat, Thérèse, Stutz, Stefan, Vaupel, Andrea, Jeay, Sébastien

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