Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

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Chemokine cooperativity is caused by competitive glycosaminoglycan binding by Verkaar, Folkert, van Offenbeek, Jody, van der Lee, Miranda M C, van Lith, Lambertus H C J, Watts, Anne O, Rops, Angelique L W M M, Aguilar, David C, Ziarek, Joshua J, van der Vlag, Johan, Handel, Tracy M, Volkman, Brian F, Proudfoot, Amanda E I, Vischer, Henry F, Zaman, Guido J R, Smit, Martine J

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A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines by Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco

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SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression by Black, Jonathan, Menderes, Gulden, Bellone, Stefania, Schwab, Carlton L, Bonazzoli, Elena, Ferrari, Francesca, Predolini, Federica, De Haydu, Christopher, Cocco, Emiliano, Buza, Natalia, Hui, Pei, Wong, Serena, Lopez, Salvatore, Ratner, Elena, Silasi, Dan-Arin, Azodi, Masoud, Litkouhi, Babak, Schwartz, Peter E, Goedings, Peter, Beusker, Patrick H, van der Lee, Miranda M C, Timmers, C Marco, Dokter, Wim H A, Santin, Alessandro D

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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers by van der Lee, Miranda M C, Groothuis, Patrick G, Ubink, Ruud, van der Vleuten, Monique A J, van Achterberg, Tanja A, Loosveld, Eline M, Damming, Désirée, Jacobs, Daniëlle C H, Rouwette, Myrthe, Egging, David F, van den Dobbelsteen, Diels, Beusker, Patrick H, Goedings, Peter, Verheijden, Gijs F M, Lemmens, Jacques M, Timmers, Marco, Dokter, Wim H A

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Clinical profile and contemporary management of patients with heart failure with preserved ejection fraction: results from the CHECK-HF registry by Uijl, A., Veenis, J. F., Brunner-La Rocca, H. P., van Empel, V., Linssen, G. C. M., Asselbergs, F. W., van der Lee, C., Eurlings, L. W. M., Kragten, H., Al-Windy, N. Y. Y., van der Spank, A., Koudstaal, S., Brugts, J. J., Hoes, A. W.

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Nonpeptidergic Allosteric Antagonists Differentially Bind to the CXCR2 Chemokine Receptor by de Kruijf, Petra, van Heteren, Jane, Lim, Herman D, Conti, Paolo G M, van der Lee, Miranda M C, Bosch, Leontien, Ho, Koc-Kan, Auld, Douglas, Ohlmeyer, Michael, Smit, Martin J, Wijkmans, Jac C H M, Zaman, Guido J R, Smit, Martine J, Leurs, Rob

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Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate by Groothuis, Patrick G, Jacobs, Daniëlle C H, Hermens, Inge A T, Damming, Désirée, Berentsen, Kim, Mattaar-Hepp, Ellen, Stokman, Marloes E M, Boekel, Tinie van, Rouwette, Myrthe, van der Vleuten, Monique A J, Sesink, Aloys, Dijcks, Fred A, Coumans, Ruud G E, Schouten, Jan, Glaudemans, Dirk H, Wijk, Daniëlle van, Blomenröhr, Marion, Kappers, Wendela A, Ubink, Ruud, van der Lee, Miranda M C, Dokter, Wim H A

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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice by Ubink, Ruud, Dirksen, Eef H C, Rouwette, Myrthe, Bos, Ebo S, Janssen, Ingrid, Egging, David F, Loosveld, Eline M, van Achterberg, Tanja A, Berentsen, Kim, van der Lee, Miranda M C, Bichat, Francis, Raguin, Olivier, van der Vleuten, Monique A J, Groothuis, Patrick G, Dokter, Wim H A

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β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor by van der Lee, Miranda M.C., Verkaar, Folkert, Wat, Jesse W.Y., van Offenbeek, Jody, Timmerman, Martijn, Voorneveld, Lonneke, van Lith, Lambertus H.C.J., Zaman, Guido J.R.

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Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist by Karstens, Willem F.J., M.B.P. Menge, Wiro, Martens, Gijs, op het Veld, Sanne J.N., Th.H. van Eupen, Jacobus, Demon, Marco, van Achterberg, Tanja A.E., Arisse-Thijssen, Monica J., Santegoeds-Lenssen, Ellen W.H., van der Lee, Miranda M.C., Ubink, Ruud, Arends, Roel J., Sesink, Aloys, Blomenröhr, Marion, Marco Timmers, C.

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Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery by van den Heijkant, T. C., Costes, L. M. M., van der Lee, D. G. C., Aerts, B., Osinga-de Jong, M., Rutten, H. R. M., Hulsewé, K. W. E., de Jonge, W. J., Buurman, W. A., Luyer, M. D. P.

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Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes by Watts, AO, Lipzig, MMH, Jaeger, WC, Seeber, RM, Zwam, M, Vinet, J, Lee, MMC, Siderius, M, Zaman, GJR, Boddeke, HWGM, Smit, MJ, Pfleger, KDG, Leurs, R, Vischer, HF

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1160 Phosphonate-antibody-drug conjugates: a novel immunostimulatory class of ADCs driving inside-out activation of Vγ9Vδ2 T cells leading to selective tumor cell killing by Helden, Mary J van, Elgersma, Ronald C, Kuppeveld, Daphne WJ van, Waalboer, Dennis, Damming, Désirée, Santegoeds-Lenssen, Ellen WH, Leenders, Inge, Laat-Arts, Karin de, Driessen-Engels, Lilian, Paradé, Marc CBC, Winkel, Menno, Scholzen, Anja, Wijk, Daniëlle EJW van, Dobbelsteen, Diels van den, Filiciotto, Genny, Assink, Laura, Rouwette, Myrthe, Spantidea, Panagiota I, Arends, Roel J, Berg, Timo K van den, Kappers, Wendela A, Verheijden, Gijs, Dokter, Wim HA, van der Lee, Miranda MC

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Pharmacological Characterization of Receptor Redistribution and β-Arrestin Recruitment Assays for the Cannabinoid Receptor 1 by Van Der Lee, Miranda M.C., Blomenröhr, Marion, Van Der Doelen, Antoon A., Wat, Jesse W.Y., Smits, Niels, Hanson, Bonnie J., Van Koppen, Chris J., Zaman, Guido J.R.

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β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR by Watts, Anne O., Verkaar, Folkert, van der Lee, Miranda M.C., Timmerman, Claudia A.W., Kuijer, Martien, van Offenbeek, Jody, van Lith, Lambertus H.C.J., Smit, Martine J., Leurs, Rob, Zaman, Guido J.R., Vischer, Henry F.

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Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands: Design and rationale of the Chronic Heart failure ESC guideline-based Cardiolo... by Brugts, J. J., Linssen, G. C. M., Hoes, A. W., Brunner-La Rocca, H. P.

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β-Arrestin Recruitment Assay for the Identification of Agonists of the Sphingosine 1-Phosphate Receptor EDG1 by Van Der Lee, Miranda M.C., Bras, Maaike, Van Koppen, Chris J., Zaman, Guido J.R.

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Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands by Brugts, J. J, Linssen, G. C. M, Hoes, A. W, Brunner-La Rocca, H. P, van >Amerongen, H, Derks, A, Hering, D, Kruik, H. J, Martherus, M, Pluimers, J, Uitzetter, A, Veldhuis, D, Huisman, N. A. M, van der Spank, A, Winter, J, Moons, A. H. M, Smit, M, Oortman, R. M, Aengenend, N, Koornstra-Wortel, H. J. J, Balhuizen, K. J, Plomp, J, van Drimmelen, A. A. M, Snoek, I, van Anken, A, van Rijn, L, Smeele, F. J. J, van Gent, M. W. F, van Lingen-Koppejan, G. C, Smits, P. A, Trossèl, H. I. S, Schaafsma, H. J, Tuin-v.d. Kolk, G, Vermeulen-v.d. Wetering, H.D, Zimmerman, J, Brakel, J. W, Nagelsmit, M. J, Veenstra, W, Aksoy, I, Meulmeester-Sinke, D. C, Monraats, P. S, Reijnierse-Buitenwerf, H. H, Witkam-Bal, A. H, Boes-van Laar, M, Schoep-Bezemer, H. M. C, Westendorp, P. H. M, van Dieën, A, Viergever, E. P, Vossebelt, E. B, Takens, L. H, de Valk-Bedijn, W. E. H, Hendrick, R, Kragten, J. A, Stoot, N. P, Barandiaran Aizpurua, M. A, Marcks, N. G. H. M, Merken, J, Corsten, L, Kelder, J. C, van Tooren, R. M, Hillebrink, T, Oosterom, L, Telgt, N, van Dalen, B. M, van Miltenburg, A, Slingerland, N, Sonneveld, B, Bird-Lake, E, Hoek-Verschoor, J, van der Ree, A, Erol-Yilmaz, A, den Hartog-Taai, L, Middelburg-Poldervaart, P, Rademaker, P. C, de Smet, S, de Theije, E. G. M. V, de Wit, T. J, Langerveld, J, Morang-van Drempt, C. J, Vermeulen, M. M, Foolen, Y, Pronk, A. C. B, Valk, L. K, Grosfeld, M. J. W, Aertsen, M, Engelen, D. J. M, Kneijber, V, van Santvoord, J, Eurlings, L. W. M, Hazeleger, R, Koopman-Verhagen, A. M, Maessen, G, Pansters, C. W. A. M, Geerlings, P. R, de Boer, M, Kolkman, A, van der Lee, C, Blonk, R, Krijger, J, Smits, J. P. P

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5PSQ-008 A digital assistant to support patients in preparing medication reconciliation: patient experiences by Maat, B, Dijkmans, A, Tenfelde, K, Van Der Lee, C, Kicken, M, de Wit, J

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