SuFEx Activation with Ca(NTf 2 ) 2 : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides by Mahapatra, Subham, Woroch, Cristian P, Butler, Todd W, Carneiro, Sabrina N, Kwan, Sabrina C, Khasnavis, Samuel R, Gu, Junha, Dutra, Jason K, Vetelino, Beth C, Bellenger, Justin, Am Ende, Christopher W, Ball, Nicholas D

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Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications by Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J

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Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads by Leverett, Carolyn A, Sukuru, Sai Chetan K, Vetelino, Beth C, Musto, Sylvia, Parris, Kevin, Pandit, Jayvardhan, Loganzo, Frank, Varghese, Alison H, Bai, Guoyun, Liu, Bin, Liu, Dingguo, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, O’Donnell, Christopher J, Subramanyam, Chakrapani

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Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators by Pettersson, Martin, Johnson, Douglas S, Subramanyam, Chakrapani, Bales, Kelly R, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Mullins, Patrick B, Navaratnam, Thayalan, Sakya, Subas M, Stiff, Cory M, Tran, Tuan P, Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R, Vetelino, Beth C, Wood, Kathleen M, Pozdnyakov, Nikolay, Verhoest, Patrick R, O’Donnell, Christopher J

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators by Pettersson, Martin, Johnson, Douglas S., Subramanyam, Chakrapani, Bales, Kelly R., am Ende, Christopher W., Fish, Benjamin A., Green, Michael E., Kauffman, Gregory W., Lira, Ricardo, Mullins, Patrick B., Navaratnam, Thayalan, Sakya, Subas M., Stiff, Cory M., Tran, Tuan P., Vetelino, Beth C., Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R., Wood, Kathleen M., O’Donnell, Christopher J.

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Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease by Pettersson, Martin, Johnson, Douglas S., Humphrey, John M., am Ende, Christopher W., Butler, Todd W., Dorff, Peter H., Efremov, Ivan V., Evrard, Edelweiss, Green, Michael E., Helal, Christopher J., Kauffman, Gregory W., Mullins, Patrick B., Navaratnam, Thayalan, O’Donnell, Christopher J., O’Sullivan, Theresa J., Patel, Nandini C., Stepan, Antonia F., Stiff, Cory M., Subramanyam, Chakrapani, Trapa, Patrick, Tran, Tuan P., Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Pustilnik, Leslie R., Steyn, Stefanus J., Wood, Kathleen M., Bales, Kelly R., Hajos-Korcsok, Eva, Verhoest, Patrick R.

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Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism by Tumey, L. Nathan, Leverett, Carolyn A, Vetelino, Beth, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Bai, Guoyun, Sukuru, Sai Chetan K, Graziani, Edmund I, Puthenveetil, Sujiet, Casavant, Jeffrey, Ratnayake, Anokha, Marquette, Kimberly, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, Tchistiakova, Lioudmila, Bessire, Andrew J, Clark, Tracey, Lucas, Judy, Hosselet, Christine, O’Donnell, Christopher J, Subramanyam, Chakrapani

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer by Gallego, Rebecca A, Cho-Schultz, Sujin, Del Bel, Matthew, Dechert-Schmitt, Anne-Marie, Donaldson, Joyann S, He, Mingying, Jalaie, Mehran, Kania, Rob, Matthews, Jean, McTigue, Michele, Tuttle, Jamison B, Risley, Hud, Zhou, Dahui, Zhou, Ru, Ahmad, Omar K, Bernier, Louise, Berritt, Simon, Braganza, John, Chen, Zecheng, Cianfrogna, Julie A, Collins, Michael, Costa Jones, Cinthia, Cronin, Ciaran N, Davis, Carl, Dress, Klaus, Edwards, Martin, Farrell, William, France, Scott P, Grable, Nicole, Johnson, Eric, Johnson, Ted W, Jones, Rhys, Knauber, Thomas, Lafontaine, Jennifer, Loach, Richard P, Maestre, Michael, Miller, Nichol, Moen, Mark, Monfette, Sebastien, Morse, Peter, Nager, Andrew Ross, Niosi, Mark, Richardson, Paul, Rohner, Allison K, Sach, Neal W, Timofeevski, Sergei, Tucker, Joseph W, Vetelino, Beth, Zhang, Lei, Nair, Sajiv K

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Design of Pyridopyrazine-1,6-dione γ‑Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability by Pettersson, Martin, Johnson, Douglas S, Humphrey, John M, Butler, Todd W, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Mullins, Patrick B, O’Donnell, Christopher J, Stepan, Antonia F, Stiff, Cory M, Subramanyam, Chakrapani, Tran, Tuan P, Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Bales, Kelly R, Pustilnik, Leslie R, Steyn, Stefanus J, Wood, Kathleen M, Verhoest, Patrick R

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active I3-secretase modulators by Pettersson, Martin, Johnson, Douglas S, Subramanyam, Chakrapani, Bales, Kelly R, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Lira, Ricardo, Mullins, Patrick B, Navaratnam, Thayalan, Sakya, Subas M, Stiff, Cory M, Tran, Tuan P, Vetelino, Beth C, Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R, Wood, Kathleen M, OaDonnell, Christopher J

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Abstract A86: Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors by Roberts, Walter Gregory, Berliner, Martin, Coleman, Kevin, Emerson, Erling, Griffor, Matt, Hulford, Catherine, Jani, Jitesh, Kath, John, LaGreca, Susan, Lin, Jing, Lorenzen, Marianne J., Marr, Eric, Martinez-Alsina, Luis, Patel, Nandini, Richter, Daniel, Roberts, Erika, Autry, Christopher, Ung, Ethan, Felix, Vajdos, Vetelino, Beth, Wessel, Matthew, Whalen, Pamela, Xu, Huiping, Yao, Lili

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