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QSP modeling of a transiently inactivating antibody-drug conjugate highlights benefit of short antibody half life
by
Khera, Eshita
,
Dharmarajan, Lekshmi
,
Hainzl, Dominik
,
Engelhardt, Volker
,
Vostiarova, Helena
,
Davis, John
,
Ebel, Nicolas
,
Wuersch, Kuno
,
Romanet, Vincent
,
Sharaby, Sherif
,
Kearns, Jeffrey D.
Published in
Journal of pharmacokinetics and pharmacodynamics
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S227928: A Novel Anti-CD74 ADC with MCL-1 Inhibitor Payload for the Treatment of Acute Myeloid Leukemia (AML) and Other Hematologic Malignancies
by
Maragno, Ana-Leticia
,
Seiss, Katherine
,
Newcombe, Rick
,
Mistry, Prakash
,
Schnell, Christian R
,
Von Arx, Fabian
,
Koenig, Julie
,
Malamas, Anthony S
,
Le Toumelin-Braizat, Gaetane
,
Bresson, Laura
,
Rocchetti, Francesca
,
Demarles, Didier
,
Kurth, Esther
,
Renteria, Lorena
,
Hainzl, Dominik
,
Engelhardt, Volker
,
Liot, Caroline
,
Madelain, Vincent
,
Kostova, Vesela
,
Starck, Jérôme-Benoit
,
Valour, Damien
,
Franzetti, Georges-Alain
,
Colland, Frederic
,
Vostiarova, Helena
,
Tschantz, William R
,
Bachmann, Nicholas
,
Palacio-Ramirez, Sebastian
,
Burger, Matthew T
,
Campbell, Jennifer M
,
Chen, Zhuoliang
,
Koenig, Robert
,
McNeill, Eric
,
Mo, Ruowei
,
Nakajima, Katsumasa
,
Palermo, Mark G
,
Shen, Yiping
,
Yu, Bing
,
Zambrowski, Mark
,
Zhang, Alan
,
Zecri, Frederic
,
Broniscer, Alberto
,
Geneste, Olivier
,
Horton, Kristin
,
D'Alessio, Joseph A
Published in
Blood
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Blood
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Journal Of Pharmacokinetics And Pharmacodynamics
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Antibodies
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Antineoplastic Agents - Administration & Dosage
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Antineoplastic Agents - Pharmacokinetics
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Biomedical And Life Sciences
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Immunoconjugates - Administration & Dosage
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