Structural insights into ligand recognition and selectivity of somatostatin receptors by Zhao, Wenli, Han, Shuo, Qiu, Na, Feng, Wenbo, Lu, Mengjie, Zhang, Wenru, Wang, Mu, Zhou, Qingtong, Chen, Shutian, Xu, Wei, Du, Juan, Chu, Xiaojing, Yi, Cuiying, Dai, Antao, Hu, Liaoyuan, Shen, Michelle Y., Sun, Yaping, Zhang, Qing, Ma, Yingli, Zhong, Wenge, Yang, Dehua, Wang, Ming-Wei, Wu, Beili, Zhao, Qiang

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Fragment-Based Computational Method for Designing GPCR Ligands by Li, Yan, Sun, Yaping, Song, Yunpeng, Dai, Dongcheng, Zhao, Zhixiong, Zhang, Qing, Zhong, Wenge, Hu, Liaoyuan A, Ma, Yingli, Li, Xun, Wang, Renxiao

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Abstract P241: A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse model by Liu, Hao, Wu, Lei, Feng, Song, Huang, Wei, Li, Huijuan, Lin, Jing, Liu, Yangyang, Mei, Liufeng, Ren, Baoqi, Xie, Julie, Yao, Lili, Zhong, Wenge

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Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells by Nowak, Mark W., Kearney, Patrick C., Sampson, Jeffrey R., Saks, Margaret E., Labarca, Cesar G., Silverman, Scott K., Zhong, Wenge, Thorson, Jon, Abelson, John N., Davidson, Norman, Schultz, Peter G., Dougherty, Dennis A., Lester, Henry A.

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Abstract PS16-22: Targeting resistance to current CDK4/6 therapies by RGT-419B, an inhibitor with optimized kinase activity spectrum by Xie, Zhi, Han, Jing, Hu, Zhilong, He, Hu, Sun, Xianqiang, Zhang, Fei, Lin, Jing, Yao, Lili, Wang, Xinjuan, Mei, Liufeng, Liu, Yangyang, Zhu, Guoyun, Chen, Xi, Zhu, Xiaotian, Zhong, Wenge

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Highly efficient ruthenium-catalyzed asymmetric hydrogenation of N-heteroaryl vinyl ethers by Song, Feng, Ren, Baoqi, Li, Lige, Xia, Fengmin, Tang, Zhiyong, Zhang, Yu, Liu, Xiaoning, Lu, Qixuan, Zhong, Wenge

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Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design by Yu, Yang, Huang, Junhong, He, Hu, Han, Jing, Ye, Geyan, Xu, Tingyang, Sun, Xianqiang, Chen, Xiumei, Ren, Xiaoming, Li, Chunlai, Li, Huijuan, Huang, Wei, Liu, Yangyang, Wang, Xinjuan, Gao, Yongzhi, Cheng, Nianhe, Guo, Na, Chen, Xibo, Feng, Jianxia, Hua, Yuxia, Liu, Chong, Zhu, Guoyun, Xie, Zhi, Yao, Lili, Zhong, Wenge, Chen, Xinde, Liu, Wei, Li, Hailong

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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor by Ma, Yanbin, Ding, Yao, Song, Xianqiang, Ma, Xiaochuan, Li, Xun, Zhang, Ning, Song, Yunpeng, Sun, Yaping, Shen, Yuqing, Zhong, Wenge, Hu, Liaoyuan A, Ma, Yingli, Zhang, Mei-Yun

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Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma by Du, Zhiqiang, Caenepeel, Sean, Shen, Yuqing, Rex, Karen, Zhang, Yanni, He, Ying, Tang, En-Tzu, Wang, Ouhong, Zhong, Wenge, Zhou, Hui, Huang, Jacqueline, Huang, Eric, Hu, Liaoyuan, Coxon, Angela, Zhang, Mingqiang

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Abstract 477: Discovery of RGT-018: A potent, selective and orally bioavailable SOS1 inhibitor for mutant KRAS-driven cancers by Xiao, Fei, Wang, Kailiang, Wang, Xinjuan, Li, Huijuan, Hu, Zhilong, Huang, Wei, Ren, Xiaoming, Feng, Teng, Yao, Lili, Lin, Jing, Li, Chunlai, Mei, Liufeng, Zhang, Zhuanzhuan, Liu, Yangyang, Chen, Xi, Zhu, Xiaotian, Zhong, Wenge, Xie, Zhi

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Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position by Kearney, Patrick C, Zhang, Haiyun, Zhong, Wenge, Dougherty, Dennis A, Lester, Henry A

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Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT3A) and Nicotinic Acetylcholine Receptors:  The Anomalous Binding Properties of Nicotine by Beene, Darren L, Brandt, Gabriel S, Zhong, Wenge, Zacharias, Niki M, Lester, Henry A, Dougherty, Dennis A

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid by Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers by Horne, Daniel B., Bartberger, Michael D., Kaller, Matthew R., Monenschein, Holger, Zhong, Wenge, Hitchcock, Stephen A.

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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease by Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.

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Abstract 5391: Preclinical evaluation of AMG 337, a highly selective small molecule MET inhibitor, in hepatocellular carcinoma by Du, Zhiqiang, Caenepeel, Sean, Shen, Yuqing, Rex, Karen, Zhang, Yanni, Tang, En-Tzu, Wang, Ouhong, Zhong, Wenge, Zhou, Hui, Huang, Jacqueline, Huang, Eric, Hu, Liaoyuan, Coxon, Angela, Zhang, Mingqiang

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors by Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Total Synthesis of Fostriecin (CI-920) by Boger, Dale L, Ichikawa, Satoshi, Zhong, Wenge

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Hydroxyethylamine-based inhibitors of BACE1: P1–P3 macrocyclization can improve potency, selectivity, and cell activity by Pennington, Lewis D., Whittington, Douglas A., Bartberger, Michael D., Jordan, Steven R., Monenschein, Holger, Nguyen, Thomas T., Yang, Bryant H., Xue, Qiufen M., Vounatsos, Filisaty, Wahl, Robert C., Chen, Kui, Wood, Stephen, Citron, Martin, Patel, Vinod F., Hitchcock, Stephen A., Zhong, Wenge

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Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhib... by Wood, Stephen, Wen, Paul H, Zhang, Jianhua, Zhu, Li, Luo, Yi, Babu-Khan, Safura, Chen, Kui, Pham, Roger, Esmay, Joel, Dineen, Thomas A, Kaller, Matthew R, Weiss, Matthew M, Hitchcock, Stephen A, Citron, Martin, Zhong, Wenge, Hickman, Dean, Williamson, Toni

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