Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery by Mateus, André, Gordon, Laurie J., Wayne, Gareth J., Almqvist, Helena, Axelsson, Hanna, Seashore-Ludlow, Brinton, Treyer, Andrea, Matsson, Pär, Lundbäck, Thomas, West, Andy, Hann, Michael M., Artursson, Per

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TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4 by Wayne, Gareth J., Deng, Su-Jun, Amour, Augustin, Borman, Satty, Matico, Rosalie, Carter, H. Luke, Murphy, Gillian

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Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability by Gordon, Laurie J., Allen, Morven, Artursson, Per, Hann, Michael M., Leavens, Bill J., Mateus, André, Readshaw, Simon, Valko, Klara, Wayne, Gareth J., West, Andy

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Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance by Pell, Theresa J., Gray, Mike B., Hopkins, Sarah J., Kasprowicz, Richard, Porter, James D., Reeves, Tony, Rowan, Wendy C., Singh, Kuljit, Tvermosegaard, Ketil B., Yaqub, Naheem, Wayne, Gareth J.

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A Phenotypic Screening Approach in Cord Blood–Derived Mast Cells to Identify Anti-Inflammatory Compounds by Kaur, Rejbinder, Sloan, Lisa A., Blanchard, Andy D., Smith, Janet L., Churcher, Ian, Wayne, Gareth J., Ludbrook, Steven B.

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5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition by Migaud, Marie E, Wilmouth, Rupert C, Mills, Gary I, Wayne, Gareth J, Risley, Catherine, Chambers, Christopher, Macdonald, Simon J F, Schofield, Christopher J

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Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation by Onos, Kristen D, Uyar, Asli, Keezer, Kelly J, Jackson, Harriet M, Preuss, Christoph, Acklin, Casey J, O'Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L, Sukoff Rizzo, Stacey J, Soto, Ileana, Carter, Gregory W, Howell, Gareth R

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The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease by Chadwick, Wayne, Maudsley, Stuart, Hull, William, Havolli, Enes, Boshoff, Eugene, Hill, Mark D W, Goetghebeur, Pascal J D, Harrison, David C, Nizami, Sohaib, Bedford, David C, Coope, Gareth, Real, Katia, Thiemermann, Christoph, Maycox, Peter, Carlton, Mark, Cole, Sarah L

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Reducing demand for overexploited wildlife products: Lessons from systematic reviews from outside conservation science by MacFarlane, Douglas, Hurlstone, Mark J., Ecker, Ullrich K. H., Ferraro, Paul J., Linden, Sander, Wan, Anita K. Y., Veríssimo, Diogo, Burgess, Gayle, Chen, Frederick, Hall, Wayne, Hollands, Gareth J., Sutherland, William J.

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SerpinI2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin by Higgins, Wayne J., Grehan, Gareth T., Wynne, Kieran J., Worrall, D. Margaret

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Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA) by Stivaros, Stavros, Garg, Shruti, Tziraki, Maria, Cai, Ying, Thomas, Owen, Mellor, Joseph, Morris, Andrew A, Jim, Carly, Szumanska-Ryt, Karolina, Parkes, Laura M, Haroon, Hamied A, Montaldi, Daniela, Webb, Nicholas, Keane, John, Castellanos, Francisco X, Silva, Alcino J, Huson, Sue, Williams, Stephen, Gareth Evans, D, Emsley, Richard, Green, Jonathan

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Therapeutic mammaplasty is a safe and effective alternative to mastectomy with or without immediate breast reconstruction by Rattay, T., Dave, Rajiv V, Potter, Shelley, Sutton, Richard, Trickey, Adam, Depasquale, Ivan, Fuller, Mairi, Heys, Steven, Ceccarino, Raffaele, Liccardo, Raffaele, Catanuto, Giuseppe, Wilkins, Alex, Wooler, Brendan, Bucknor, Alexandra, Reissis, Dimitris, Wood, Simon, Henry, Francis P, Khan, Shazia M, Massey, Julia, Gill, Emma, Young, Oliver, McGill, David, Rattay, Tim, Kenny, Frances, Krupa, Jaroslaw, Saibene, Tania, Gvaramadze, Anzors, Barua, Ellora, Nguyen, Dai, Guest, Francesca, Pain, Simon J, Hussien, Maged I, Harnett, Adrian, Colizzi, Livio, Li, Alessandro Quattrini, MacLean, Gael, Shetty, Geeta, Grassi, Veronica, Basu, Naren, Michalakis, Ioannis, Dunn, Julie, Olsen, Sisse, Allan, Anna, Woollard, Alex, Chana, Jagdeep, Holcombe, Chris, Irakleidis, Foivos, Allum, William, Cain, Henry, Fiddes, Roanne, Slade‐Sharman, Diana, Khan, Mansoor, Tevlin, Ruth, Kryjak, Zbigniew, Ali, Deedar, Asaad, Oubida, Mathen, Vinod, Harvey, James, Rizkalla, Maged, Kirby, Robert, Callaghan, Maria, Mullan, Michelle, Taylor, Jevan, Jones, Ben Mancey, Fuller, Mairi, Agrawal, Amit, Refsum, Sigi, Ibrahim, Abdulla, Cawthorn, Simon, Accurso, Antonello, McManus, Penny, Roshanlall, Chandeena, Kokan, Jalal, Ogsto, Keith, Al‐Allak, Asmaa, Khalil, Haitham, Kirkpatrick, Katharine, Safdar, Gazalla, Gutteridge, Ellie, Hallam, Kelly, Asgeirron, Kristjan, D'Auria, Marta, McCulley, Stephen, Remoundos, Dionysios‐Dennis, Chaidos, Nikos, Rezulski, Jan, Goh, Steven, Abdullah, Tholkifl, Potter, Shelley, Godden, Amy, Krupa, Katherine, Kim, Baek, Nicholson, Stewart, Taylor, Lauren, Darragh, Lynn, Bathla, Sonia, Bhojwani, Ajay Ashok, Ibrahim, Ibrahim, Murphy, John, Frame, Richard

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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Heparan Sulfate Regulates Amyloid Precursor Protein Processing by BACE1, the Alzheimer's β-Secretase by Scholefield, Zoe, Yates, Edwin A., Wayne, Gareth, Amour, Augustin, McDowell, William, Turnbull, Jeremy E.

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Genetic variants for head size share genes and pathways with cancer by Evans, Tavia E., Sargurupremraj, Muralidharan, Jian, Xueqiu, van Dam-Nolen, Dianne H.K., Lamballais, Sander, Reinbold, Céline S., Scholz, Markus, Atkins, Joshua R., Patel, Yash, Beyer, Frauke, Bis, Joshua C., Dartigues, Jean-François, DeCarli, Charles, Ford, Judith M., Freedman, Barry I., Green, Melissa J., Homuth, Georg, Ikram, M. Kamran, Jack, Clifford R., Knodt, Annchen R., Macciardi, Fabio, Arfanakis, Konstantinos, Aribisala, Benjamin S., Bastin, Mark E., Cheng, Ching-Yu, Gottesman, Rebecca F., Liewald, David C.M., Lopez, Lorna M., Lopez, Oscar, Niessen, Wiro J., Sacco, Ralph L., Völzke, Henry, Yanek, Lisa, Yang, Jingyun, Bernard, Manon, Brickman, Adam M., Brodaty, Henry, Buitelaar, Jan K., Carr, Vaughan J., Chakravarty, M. Mallar, Ching, Christopher R.K., Curran, Joanne E., den Braber, Anouk, Erk, Susanne, Fedko, Iryna O., Fernández, Guillén, Fisher, Simon E., Ge, Tian, Goldman, Aaron L., Green, Robert C., Greven, Corina U., Hashimoto, Ryota, Henskens, Frans, Ho, Beng-Choon, Holmes, Avram J., Jablensky, Assen, Jia, Tianye, Kwok, John B., McDonald, Colm, McWhirter, Olvera, Rene L., Pandolfo, Massimo, Pantelis, Christos, Pappa, Irene, Reppermund, Simone, Rose, Emma Jane, Schall, Ulrich, Schumann, Gunter, Shen, Li, Sprooten, Emma, Turner, Jessica A., Van Haren, Neeltje E.M., van 't Ent, Dennis, Wen, Wei, Wright, Margaret J., Wu, Jingqin, Mazoyer, Bernard, Medland, Sarah E., Moebus, Susanne, Mosley, Thomas H., Mühleisen, Thomas W., Nagata, Manabu, Reay, William R., Setoh, Kazuya, Stein, Jason L., Teumer, Alexander, van der Lugt, Aad, Werring, David J., Wittfeld, Katharina, Yang, Qiong, Le Grand, Quentin, Bowden, Donald W., Hariri, Ahmad R., Cheung, Ching-Lung, White, Tonya, Koudstaal, Peter J., Fornage, Myriam, Grabe, Hans J., Ikram, M. Arfan, Adams, Hieab H.H.

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Psychosocial impact of undergoing prostate cancer screening for men with BRCA 1 or BRCA 2 mutations by Bancroft, Elizabeth K., Saya, Sibel, Page, Elizabeth C., Myhill, Kathryn, Thomas, Sarah, Pope, Jennifer, Chamberlain, Anthony, Hart, Rachel, Glover, Wayne, Cook, Jackie, Rosario, Derek J., Helfand, Brian T., Hutten Selkirk, Christina, Davidson, Rosemarie, Longmuir, Mark, Eccles, Diana M., Gadea, Neus, Brewer, Carole, Barwell, Julian, Salinas, Monica, Greenhalgh, Lynn, Tischkowitz, Marc, Henderson, Alex, Evans, David Gareth, Buys, Saundra S., Eeles, Rosalind A., Aaronson, Neil K.

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A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates by Thomas, Daniel A., Francis, Peter, Smith, Carla, Ratcliffe, Steven, Ede, Nicholas J., Kay, Corinne, Wayne, Gareth, Martin, Steve L., Moore, Keith, Amour, Augustin, Hooper, Nigel M.

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BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs) by Clarke, Brian, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Faller, Andrew, Hawkins, Julie, Hussain, Ishrut, MacPherson, David, Maile, Graham, Matico, Rosalie, Milner, Peter, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Riddell, David, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Stanway, Steven, Stemp, Geoffrey, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Ward, John, Wayne, Gareth

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Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, East, Philip, Hawkins, Julie, Howes, Colin, Hussain, Ishrut, Jeffrey, Phil, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J, Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S, Wayne, Gareth

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

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