Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identi... by Davies, Thomas G, Wixted, William E, Coyle, Joseph E, Griffiths-Jones, Charlotte, Hearn, Keisha, McMenamin, Rachel, Norton, David, Rich, Sharna J, Richardson, Caroline, Saxty, Gordon, Willems, Henriëtte M. G, Woolford, Alison J.-A, Cottom, Joshua E, Kou, Jen-Pyng, Yonchuk, John G, Feldser, Heidi G, Sanchez, Yolanda, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Podolin, Patricia L, Yan, Hongxing, Callahan, James F, Heightman, Tom D, Kerns, Jeffrey K

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Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2... by Heightman, Tom D, Callahan, James F, Chiarparin, Elisabetta, Coyle, Joseph E, Griffiths-Jones, Charlotte, Lakdawala, Ami S, McMenamin, Rachel, Mortenson, Paul N, Norton, David, Peakman, Torren M, Rich, Sharna J, Richardson, Caroline, Rumsey, William L, Sanchez, Yolanda, Saxty, Gordon, Willems, Henriëtte M. G, Wolfe, Lawrence, Woolford, Alison J.-A, Wu, Zining, Yan, Hongxing, Kerns, Jeffrey K, Davies, Thomas G

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protei... by Norton, David, Bonnette, William G, Callahan, James F, Carr, Maria G, Griffiths-Jones, Charlotte M, Heightman, Tom D, Kerns, Jeffrey K, Nie, Hong, Rich, Sharna J, Richardson, Caroline, Rumsey, William, Sanchez, Yolanda, Verdonk, Marcel L, Willems, Henriëtte M. G, Wixted, William E, Woolford, Alison J.-A, Wu, Zining, Davies, Thomas G

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Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor by Willems, Henriëtte M. G, Edwards, Simon, Boffey, Helen K, Chawner, Stephen J, Green, Christopher, Romero, Tamara, Winpenny, David, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P

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Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold by Hardcastle, Ian R, Ahmed, Shafiq U, Atkins, Helen, Farnie, Gillian, Golding, Bernard T, Griffin, Roger J, Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J, Kitching, Martin S, Newell, David R, Norbedo, Stefano, Northen, Julian S, Reid, Rebecca J, Saravanan, K, Willems, Henriëtte M. G, Lunec, John

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The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules by Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

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Generation and Selection of Novel Estrogen Receptor Ligands Using the De Novo Structure-Based Design Tool, SkelGen by Firth-Clark, Stuart, Willems, Henriëtte M. G, Williams, Anthony, Harris, William

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Systematic Investigation of the Permeability of Androgen Receptor PROTACs by Scott, Duncan E, Rooney, Timothy P. C, Bayle, Elliott D, Mirza, Tashfina, Willems, Henriette M. G, Clarke, Jonathan H, Andrews, Stephen P, Skidmore, John

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De Novo Ligand Design to Partially Flexible Active Sites:  Application of the ReFlex Algorithm to Carboxypeptidase A, Acetylcholinesterase, and the Estrogen Receptor by Firth-Clark, Stuart, Kirton, Stewart B, Willems, Henriëtte M. G, Williams, Anthony

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The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) by Aldred, Gregory G, Rooney, Timothy P. C, Willems, Henriette M. G, Boffey, Helen K, Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H, Andrews, Stephen P

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Receptor Flexibility in the in Silico Screening of Reagents in the S1‘ Pocket of Human Collagenase by Källblad, Per, Todorov, Nikolay P, Willems, Henriëtte M. G, Alberts, Ian L

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Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction by Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Calvert, A. Hilary, Curtin, Nicola J., Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J., Kitching, Martin S., Newell, David R., Norbedo, Stefano, Northen, Julian S., Reid, Rebecca J., Saravanan, K., Willems, Henriëtte M.G., Lunec, John

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Development of Selective Phosphatidylinositol 5‑Phosphate 4‑Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode by Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

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Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration by Birkle, Timothy J.Y., Willems, Henriette M.G., Skidmore, John, Brown, Guy C.

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SynthFormer: Equivariant Pharmacophore-based Generation of Molecules for Ligand-Based Drug Design by Jocys, Zygimantas, Willems, Henriette M G, Farrahi, Katayoun

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Acute Normovolemic Hemodilution in the Pig Is Associated with Renal Tissue Edema, Impaired Renal Microvascular Oxygenation, and Functional Loss by Konrad, Franziska M, Mik, Egbert G, Bodmer, Sander I A, Ates, N Bahar, Willems, Henriëtte F. E M, Klingel, Karin, de Geus, Hilde R H, Stolker, Robert Jan, Johannes, Tanja

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Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6) by Hendrick, Alan G, Müller, Ilka, Willems, Henriëtte, Leonard, Philip M, Irving, Steve, Davenport, Richard, Ito, Takashi, Reeves, Jenny, Wright, Susanne, Allen, Vivienne, Wilkinson, Stephen, Heffron, Helen, Bazin, Richard, Turney, Jennifer, Mitchell, Philip J

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Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels by Dehghan, Abbas, Dupuis, Josée, Barbalic, Maja, Bis, Joshua C, Eiriksdottir, Gudny, Lu, Chen, Pellikka, Niina, Wallaschofski, Henri, Kettunen, Johannes, Henneman, Peter, Baumert, Jens, Strachan, David P, Fuchsberger, Christian, Vitart, Veronique, Wilson, James F, Paré, Guillaume, Naitza, Silvia, Rudock, Megan E, Surakka, Ida, de Geus, Eco J C, Alizadeh, Behrooz Z, Guralnik, Jack, Shuldiner, Alan, Tanaka, Toshiko, Zee, Robert Y L, Schnabel, Renate B, Nambi, Vijay, Kavousi, Maryam, Ripatti, Samuli, Nauck, Matthias, Smith, Nicholas L, Smith, Albert V, Sundvall, Jouko, Scheet, Paul, Liu, Yongmei, Ruokonen, Aimo, Rose, Lynda M, Larson, Martin G, Hoogeveen, Ron C, Freimer, Nelson B, Teumer, Alexander, Tracy, Russell P, Launer, Lenore J, Buring, Julie E, Yamamoto, Jennifer F, Folsom, Aaron R, Sijbrands, Eric J G, Pankow, James, Elliott, Paul, Keaney, John F, Sun, Wei, Sarin, Antti-Pekka, Fontes, João D, Badola, Sunita, Astor, Brad C, Hofman, Albert, Pouta, Anneli, Werdan, Karl, Greiser, Karin H, Kuss, Oliver, Meyer zu Schwabedissen, Henriette E, Thiery, Joachim, Jamshidi, Yalda, Nolte, Ilja M, Soranzo, Nicole, Spector, Timothy D, Völzke, Henry, Parker, Alexander N, Aspelund, Thor, Bates, David, Young, Lauren, Tsui, Kim, Siscovick, David S, Guo, Xiuqing, Rotter, Jerome I, Uda, Manuela, Schlessinger, David, Rudan, Igor, Hicks, Andrew A, Penninx, Brenda W, Thorand, Barbara, Gieger, Christian, Coresh, Joe, Willemsen, Gonneke, Harris, Tamara B, Uitterlinden, Andre G, Järvelin, Marjo-Riitta, Rice, Kenneth, Radke, Dörte, Salomaa, Veikko, Willems van Dijk, Ko, Boerwinkle, Eric, Vasan, Ramachandran S, Ferrucci, Luigi, Gibson, Quince D, Bandinelli, Stefania, Snieder, Harold, Boomsma, Dorret I, Xiao, Xiangjun, Campbell, Harry

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Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Cong... by Chu, Wan-Yu, Nijman, Maaike, Stegeman, Raymond, Breur, Johannes M. P. J., Jansen, Nicolaas J. G., Nijman, Joppe, van Loon, Kim, Koomen, Erik, Allegaert, Karel, Benders, Manon J. N. L., Dorlo, Thomas P. C., Huitema, Alwin D. R.

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Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD by Budulac, Simona E, Postma, Dirkje S, Hiemstra, Pieter S, Kunz, Lisette I Z, Siedlinski, Mateusz, Smit, Henriette A, Vonk, Judith M, Rutgers, Bea, Timens, Wim, Boezen, H Marike

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