Sarcasm in Sight and Sound: Benchmarking and Expansion to Improve Multimodal Sarcasm Detection by Bhosale, Swapnil, Chaudhuri, Abhra, Williams, Alex Lee Robert, Tiwari, Divyank, Dutta, Anjan, Zhu, Xiatian, Bhattacharyya, Pushpak, Kanojia, Diptesh

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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups by Dikilitas, Ozan, Schaid, Daniel J., Kosel, Matthew L., Carroll, Robert J., Chute, Christopher G., Denny, Joshua C., Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P., Lee, Ming Ta Michael, Pacheco, Jennifer A., Rowley, Robb, Sleiman, Patrick M., Stein, C. Michael, Sturm, Amy C., Wei, Wei-Qi, Wiesner, Georgia L., Williams, Marc S., Zhang, Yanfei, Manolio, Teri A., Kullo, Iftikhar J.

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Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England by Volz, Erik, Mishra, Swapnil, Chand, Meera, Barrett, Jeffrey C., Johnson, Robert, Geidelberg, Lily, Hinsley, Wes R., Laydon, Daniel J., Dabrera, Gavin, O’Toole, Áine, Amato, Robert, Ragonnet-Cronin, Manon, Harrison, Ian, Jackson, Ben, Ariani, Cristina V., Boyd, Olivia, Loman, Nicholas J., McCrone, John T., Gonçalves, Sónia, Jorgensen, David, Myers, Richard, Hill, Verity, Jackson, David K., Gaythorpe, Katy, Groves, Natalie, Sillitoe, John, Kwiatkowski, Dominic P., Flaxman, Seth, Ratmann, Oliver, Bhatt, Samir, Hopkins, Susan, Gandy, Axel, Rambaut, Andrew, Ferguson, Neil M.

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Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial by Böhm, Michael, Kario, Kazuomi, Mahfoud, Felix, Weber, Michael A, Schmieder, Roland E, Tsioufis, Konstantinos, Pocock, Stuart, Konstantinidis, Dimitris, Lee, David P, Ewen, Sebastian, Cohen, Debbie L, Lea, Janice, Agdirlioglu, Tolga, Reedus, Denise, Sharp, Andrew S P, Sharif, Faisal, DeBruin, Vanessa, Cohen, Sidney A, Brar, Sandeep, Akarca, Ertan, Aoki, Jiro, Aronow, Herbert, Barton, John, Batson, Bryan, Bell, Chris, Binner, Christian, Bloom, Jason, Blossom, Benjamin, Butler, Michael, Campbell, James, Chapman, Neil, Chasen, Craig, Chia, Beth, Connolly, Niall, Contreras, Johanna, Cusack, Ronan, David, Shukri, Dederer, Juliane, Denker, Matthew, Desch, Udo, Dimitriadis, Kyriakos, Estess, John, Ferguson, Lee, Fudim, Marat, Garcia, Santiago, Garton, Alex, Hardesty, Peggy, Hartung, Phillip, Hill, Douglas, Jay, Desmond, Johnson, James, Jones, Schuyler, Jung, Susanne, Kalos, Theodoros, Kannenkeril, Dennis, Kobayashi, Taisei, Komori, Takahiro, Kouparanis, Antonios, Krasnow, Joshua, Lavoie, Marc A, Lurz, Philipp, Meade, Ashley, Moore, Naing, Mori, Fumiko, Munch, Phillip, Murray, Jennifer, Ninomiya, Kai, O'Connor, Tim, Onsrud, Rachel, Porr, Wendy, Rizik, David, Robison, Monique, Rothstein, Marcos, Rough, Randolph, Saavedra, Jose, Saba, Souhell, Schwartz, Robert, Selcer, Shaun, Shadman, Ramin, Shemin, Douglas, Shishehbor, Mehdi, Shun-Shin, Matthew, Singh, Jasvindar, Singh, Avneet, Sirajeldin, Yassir, Skeik, Nedaa, Statton, Sarah, Stehli, Julia, Steigerwalt, Susan, Striepe, Kristina, Stuck, Jason, Tanaka, Tetsu, Traverse, Jay, Tyson, Crystal, Vasquez, Alejandro, Vemulapalli, Sreekanth, Waki, Hirotaka, Yahagi, Kazuyuki, Yeung, Alan, Ziakas, Antonios

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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial by Garvey, W Timothy, Frias, Juan P, Jastreboff, Ania M, le Roux, Carel W, Sattar, Naveed, Aizenberg, Diego, Mao, Huzhang, Zhang, Shuyu, Ahmad, Nadia N, Bunck, Mathijs C, Benabbad, Imane, Zhang, Xiaotian M, Abalos, Franklin H., Manghi, Federico C.P., Zaidman, Cesar J., Vico, Marisa L., Aizenberg, Diego, Costanzo, Pablo R., Serra, Leonardo P., MacKinnon, Ignacio J., Hissa, Miguel N., Vidotti, Maria H., Kerr Saraiva, Jose F., Alves, Breno B., Franco, Denise R., Moratto, Otavio, Murthy, Sreenivasa, Goyal, Ghanshyam, Yamasaki, Yoshimitsu, Sato, Nobuyuki, Inoue, Satoshi, Asakura, Taro, Shestakova, Marina, Khaykina, Elena, Troshina, Ekaterina, Vorokhobina, Natalia, Ametov, Alexander, Tu, Shih-Te, Yang, Chwen-Yi, Lee, I-Te, Huang, Chien-Ning, Ou, Horng-Yih, Freeman, George, Machineni, Sriram, Klein, Klara, Sultan, Senan, Parsa, Alan, Otero-Martinez, Juan, Gonzalez, Alex, Bhargava, Anuj, Brian, Susan, Ince, Carlos, Plantholt, Stephen, Cole, Jeremy, Lacour, Audrey, Vega, Damaris, de Souza, Jose, Rohlf, Jane L., St. John, Roy C., Horowitz, Barry, Audish, Hanid, Galindo, Rodolfo, Umpiperrez, Guillermo, Ard, Jamy, Curtis, Brian, Garvey, William T., Fraser, Neil J., Mandry, Jose, Mohseni, Rizwana, Mayfield, Ronald, Powell, Talessa, Vance, Carl, Ong, Stephen, Lewy-Alterbaum, Ana L., Murray, Alexander, Al-Karadsheh, Amer, Yacoub, Tamer, Roberts, Kevin, Fried, David L., Rosenstock, Julio, Pulla, Bharathi, Bode, Bruce, Frias, Juan, Klaff, Leslie, Brazg, Ronald, Van, Joanna, Tan, Anjanette, Briskin, Toby, Rhee, Margaret, Chaicha-Brom, Tira, Hartley, Paul A., Nunez, Lazaro, Cortes-Maisonet, Gregorio, Soucie, Gary, Hsia, Stanley, Jones, Thomas

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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids by Reimer, Katharina C., Nagai, James S., Varghese, Finny S., Overheul, Gijs J., Roverts, Rona, Willemsen, Brigith, Beukenboom, Marcel, Dunnen, Wilfred den, Triana, Sergio H., Timm, Marie-Cherelle, van den Berge, Bartholomeus T., Nlandu, Quincy, Heijnert, Joelle, Bindels, Eric M.J., Hoogenboezem, Remco M., Mooren, Fieke, Kuppe, Christoph, Grünberg, Katrien, Steenbergen, Eric J., Czogalla, Jan, Sommerdijk, Nico, Akiva, Anat, Boor, Peter, Huber, Tobias B., Bar-David, Elad, Barr, Haim, Boby, Melissa L., Borden, Bruce, Bowman, Gregory R., Brun, Juliane, BVNBS, Sarma, Carbery, Anna, Chernychenko, Eugene, Clyde, Austin, Coffland, Joseph E., Cole, Jason, Cox, Lisa, Dudgeon, Tim, Dunnett, Louise, Erez, Noam, Fate, Gwen, Ferrins, Lori, Foster, Richard, Foster, Holly, Gabizon, Ronen, Gawriljuk, Victor O., Gehrtz, Paul, Gileadi, Carina, Giroud, Charline, Glen, Robert, Gorichko, Marian, Griffen, Ed J., Heer, Jag, Hill, Michelle, Horrell, Sam, Jajack, Andrew, De Jonghe, Steven, Kantsadi, Anastassia L., Koekemoer, Lizbe, Lee, Alpha A., Lefker, Bruce A., Macdonald, Hannah Bruce, Maclean, Beth, McCorkindale, Willam, McGovern, Briana L., Michurin, Oleg, Morris, Aaron, Morris, Garret M., Neyts, Johan, Oliva, Glaucius, Overheul, Gijs J., Owen, David, Psenak, Vladimir, Pai, Ruby, Paran, Nir, Perry, Benjamin, Pingle, Maneesh, Politi, Boaz, Powell, Ailsa, Puni, Reut, Resnick, Efrat, Rosales, Romel, Schofield, Chris, Shafeev, Mikhail, Sittner, Assa, Skyner, Rachael, Spencer, John, Tamir, Hadas, Tennant, Rachael, Tumber, Anthony, van Rij, Ronald P., Voelz, Vincent, Volkamer, Andra, von Delft, Annette, White, Kris M., Wright, Nathan, Zidane, Hadeer, Costa, Ivan G., Schneider, Rebekka K., Smeets, Bart

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Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy by Young, Paul, Mackle, Diane, Bellomo, Rinaldo, Bailey, Michael, Beasley, Richard, Deane, Adam, Eastwood, Glenn, Finfer, Simon, Freebairn, Ross, King, Victoria, Linke, Natalie, Litton, Edward, McArthur, Colin, McGuinness, Shay, Panwar, Rakshit

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Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors by Beckmann, Pauline J, Larson, Jon D, Larsson, Alex T, Ostergaard, Jason P, Wagner, Sandra, Rahrmann, Eric P, Shamsan, Ghaidan A, Otto, George M, Williams, Rory L, Wang, Jun, Lee, Catherine, Tschida, Barbara R, Das, Paramita, Dubuc, Adrian M, Moriarity, Branden S, Picard, Daniel, Wu, Xiaochong, Rodriguez, Fausto J, Rosemarie, Quincy, Krebs, Ryan D, Molan, Amy M, Demer, Addison M, Frees, Michelle M, Rizzardi, Anthony E, Schmechel, Stephen C, Eberhart, Charles G, Jenkins, Robert B, Wechsler-Reya, Robert J, Odde, David J, Huang, Annie, Taylor, Michael D, Sarver, Aaron L, Largaespada, David A

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An open repository of real-time COVID-19 indicators by Reinhart, Alex, Brooks, Logan, Jahja, Maria, Rumack, Aaron, Tang, Jingjing, Agrawal, Sumit, Saeed, Wael Al, Arnold, Taylor, Basu, Amartya, Bien, Jacob, Cabrera, Ángel A., Chin, Andrew, Chua, Eu Jing, Clark, Brian, Colquhoun, Sarah, DeFries, Nat, Farrow, David C., Forlizzi, Jodi, Grabman, Jed, Gratzl, Samuel, Green, Alden, Haff, George, Han, Robin, Harwood, Kate, Hu, Addison J., Hyde, Raphael, Hyun, Sangwon, Joshi, Ananya, Kim, Jimi, Kuznetsov, Andrew, La Motte-Kerr, Wichada, Lee, Yeon Jin, Lee, Kenneth, Lipton, Zachary C., Liu, Michael X., Mackey, Lester, Mazaitis, Kathryn, McDonald, Daniel J., McGuinness, Phillip, Narasimhan, Balasubramanian, O’Brien, Michael P., Oliveira, Natalia L., Patil, Pratik, Perer, Adam, Politsch, Collin A., Rajanala, Samyak, Rucker, Dawn, Scott, Chris, Shah, Nigam H., Shankar, Vishnu, Sharpnack, James, Shemetov, Dmitry, Simon, Noah, Smith, Benjamin Y., Srivastava, Vishakha, Tan, Shuyi, Tibshirani, Robert, Tuzhilina, Elena, Van Nortwick, Ana Karina, Ventura, Valérie, Wasserman, Larry, Weaver, Benjamin, Weiss, Jeremy C., Whitman, Spencer, Williams, Kristin, Rosenfeld, Roni, Tibshirani, Ryan J.

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Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy by Larivière, Delphine, Abueg, Linelle, Brajuka, Nadolina, Gallardo-Alba, Cristóbal, Grüning, Bjorn, Ko, Byung June, Ostrovsky, Alex, Palmada-Flores, Marc, Pickett, Brandon D., Rabbani, Keon, Antunes, Agostinho, Balacco, Jennifer R., Chaisson, Mark J. P., Cheng, Haoyu, Collins, Joanna, Couture, Melanie, Denisova, Alexandra, Fedrigo, Olivier, Gallo, Guido Roberto, Giani, Alice Maria, Gooder, Grenville MacDonald, Horan, Kathleen, Jain, Nivesh, Johnson, Cassidy, Kim, Heebal, Lee, Chul, Marques-Bonet, Tomas, O’Toole, Brian, Rhie, Arang, Secomandi, Simona, Sozzoni, Marcella, Tilley, Tatiana, Uliano-Silva, Marcela, van den Beek, Marius, Williams, Robert W., Waterhouse, Robert M., Phillippy, Adam M., Jarvis, Erich D., Schatz, Michael C., Nekrutenko, Anton, Formenti, Giulio

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Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial by Helton, Kathleen J., Adams, Robert J., Kesler, Karen L., Lockhart, Alex, Aygun, Banu, Driscoll, Catherine, Heeney, Matthew M., Jackson, Sherron M., Krishnamurti, Lakshmanan, Miller, Scott T., Sarnaik, Sharada A., Schultz, William H., Ware, Russell E.

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Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes by Feliciano, Pamela, Zhou, Xueya, Astrovskaya, Irina, Turner, Tychele N., Wang, Tianyun, Brueggeman, Leo, Barnard, Rebecca, Hsieh, Alexander, Snyder, LeeAnne Green, Muzny, Donna M., Sabo, Aniko, Gibbs, Richard A., Eichler, Evan E., O’Roak, Brian J., Michaelson, Jacob J., Volfovsky, Natalia, Shen, Yufeng, Chung, Wendy K.

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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders by Wang, Tianyun, Hoekzema, Kendra, Vecchio, Davide, Wu, Huidan, Sulovari, Arvis, Coe, Bradley P., Gillentine, Madelyn A., Wilfert, Amy B., Perez-Jurado, Luis A., Kvarnung, Malin, Sleyp, Yoeri, Earl, Rachel K., Rosenfeld, Jill A., Geisheker, Madeleine R., Han, Lin, Du, Bing, Barnett, Chris, Thompson, Elizabeth, Shaw, Marie, Carroll, Renee, Friend, Kathryn, Catford, Rachael, Palmer, Elizabeth E., Zou, Xiaobing, Ou, Jianjun, Li, Honghui, Guo, Hui, Gerdts, Jennifer, Avola, Emanuela, Calabrese, Giuseppe, Elia, Maurizio, Greco, Donatella, Lindstrand, Anna, Nordgren, Ann, Anderlid, Britt-Marie, Vandeweyer, Geert, Van Dijck, Anke, Van der Aa, Nathalie, McKenna, Brooke, Hancarova, Miroslava, Bendova, Sarka, Havlovicova, Marketa, Malerba, Giovanni, Bernardina, Bernardo Dalla, Muglia, Pierandrea, van Haeringen, Arie, Hoffer, Mariette J. V., Franke, Barbara, Cappuccio, Gerarda, Delatycki, Martin, Lockhart, Paul J., Manning, Melanie A., Liu, Pengfei, Scheffer, Ingrid E., Brunetti-Pierri, Nicola, Rommelse, Nanda, Amaral, David G., Santen, Gijs W. E., Trabetti, Elisabetta, Sedláček, Zdeněk, Michaelson, Jacob J., Pierce, Karen, Courchesne, Eric, Kooy, R. Frank, Nordenskjöld, Magnus, Romano, Corrado, Peeters, Hilde, Bernier, Raphael A., Gecz, Jozef, Xia, Kun, Eichler, Evan E.

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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer by Brunton, Holly, Caligiuri, Giuseppina, Cunningham, Richard, Upstill-Goddard, Rosie, Garner, Ian M., Nourse, Craig, Wright, Derek W., Nixon, Colin, Jamieson, Nigel B., McGregor, Grant A., Evers, Lisa, McKay, Colin J., Gulati, Aditi, Brough, Rachel, Pettitt, Stephen J., Dziubinski, Michele L., Grützmann, Robert, Curry, Edward, Allison, Sarah, Biankin, Andrew V., Dreyer, Stephan, McDade, Brian, McElroy, Daniel, Ramsay, Donna, Upstill-Goddard, Rosie, Jamieson, Nigel B., Westwood, Paul, Mawson, Amanda, Scarlett, Christopher J., Brancato, Mary-Anne L., Simpson, Skye H., Thomas, Michelle T., Chin, Venessa T., Humphris, Jeremy L., Mead, R. Scott, Nagrial, Adnan M., Pettit, Jessica, Wu, Jianmin, DiPietro, Renee, Steinmann, Angela, Pinho, Andreia V., Giry-Laterriere, Marc, Musgrove, Elizabeth A., Miller, David K., Song, Sarah, Nourbakhsh, Ehsan, Wani, Shivangi, Gongora, Milena, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Bruxner, Tim, Pearson, John V., Nagaraj, Shivashankar, Kazakoff, Stephen, Waddell, Nick, Quek, Kelly, Pavlakis, Nick, Asghari, Ray, Pavey, Darren, Das, Amitabha, Ismail, Kasim, Lam, Vincent W., Richardson, Arthur, James, Virginia, Kench, James G., Joseph, David, Laycock, Andrew, Epari, Krishna P., Fletcher, David R., Zeps, Nikolajs, Beilin, Maria, Feeney, Kynan, Worthley, Chris, Tan, Chuan P., Debrencini, Tamara, Chen, John, Brooke-Smith, Mark E., Tang, Henry, Clouston, Andrew D., Fawcett, Jonathan W., Slater, Kellee, Hatzifotis, Michael, Nikfarjam, Mehrdad, Eshleman, James R., Hruban, Ralph H., Schulick, Richard D., Scarpa, Aldo, Scardoni, Maria, Tempero, Margaret A., Pajic, Marina, Petersen, Gloria M., Shanks, Emma, Pilarsky, Christian, Grimmond, Sean E., Morton, Jennifer P., Chang, David K., Bailey, Peter J., Biankin, Andrew V.

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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility by Chintalapudi, Sumana R., Maria, Doaa, Di Wang, Xiang, Bailey, Jessica N. Cooke, Hysi, Pirro G., Wiggs, Janey L., Williams, Robert W., Jablonski, Monica M.

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Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease by Hung, Adriana M, Assimon, Victoria A, Chen, Hua-Chang, Yu, Zhihong, Vlasschaert, Caitlyn, Triozzi, Jefferson L, Chan, Helen, Wheless, Lee, Wilson, Otis, Shah, Shailja C, Mack, Taralynn, Thompson, Trevor, Matheny, Michael E, Chandrasekar, Saranya, Mozaffari, Sahar V, Chung, Cecilia P, Tsao, Philip, Susztak, Katalin, Siew, Edward D, Estrada, Karol, Gaziano, J Michael, Graham, Robert R, Tao, Ran, Hoek, Maarten, Robinson-Cohen, Cassianne, Green, Eric M, Bick, Alexander G

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Outcomes Following Severe Distal Tibial, Ankle, and/or Mid/Hindfoot Trauma: Comparison of Limb Salvage and Transtibial Amputation (OUTLET) by Major Extremity Trauma Research Consortium (METRC), Major Extremity Trauma Research Consortium (METRC)

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia by Trubetskoy, Vassily, Qi, Ting, Bryois, Julien, Chen, Chia-Yen, Magnusson, Sigurdur, Kim, Minsoo, Adams, Mark, Agartz, Ingrid, Agerbo, Esben, Athanasiu, Lavinia, Bacanu, Silviu A., Calkins, Monica E., Carr, Vaughan J., Consoli, Angèle, Costas, Javier, Davis, Kenneth L., Degenhardt, Franziska, Dickerson, Faith, Frustaci, Alessandra, Giegling, Ina, Goldstein, Jacqueline I., González Peñas, Javier, Hayward, Caroline, Howrigan, Daniel P., Ikeda, Masashi, Kam-Thong, Tony, Kamatani, Yoichiro, Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kubo, Michiaki, Lazzeroni, Laura C., Lehrer, Douglas S., Li, Miaoxin, Liu, Chih-Min, Loughland, Carmel M., Mallet, Jacques, Mattheisen, Manuel, McCarley, Robert W., Meier, Sandra, Milani, Lili, Milanova, Vihra, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Olincy, Ann, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Radant, Allen D., Saker-Delye, Safaa, Sanjuan, Julio, Savitz, Adam, Seidman, Larry J., Sim, Kang, Stain, Helen J., Streit, Fabian, Strengman, Eric, Ta, Thi Minh Tam, Terao, Chikashi, Toncheva, Draga, Veijola, Juha, Waddington, John, Walter, Henrik, Webb, Bradley T., Wu, Jing Qin, Xu, Zhida, Ayub, Muhammad, Bertolino, Alessandro, Buccola, Nancy G., Byerley, William F., Hwu, Hai-Gwo, McCarroll, Steven A., Neil, Amanda L., Smoller, Jordan W., Vilella, Elisabet, Xu, Shuhua, Braff, David, Buxbaum, Joseph D., Cichon, Sven, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Iwata, Nakao, Kirov, George, Lee, Jimmy, Li, Qingqin S., Malhotra, Anil K., Malhotra, Dheeraj, McQuillin, Andrew, Morgan, Vera A., Nöthen, Markus M., Saka, Meram C., Sanders, Alan R., Serretti, Alessandro, van Os, Jim, Yu, Xin, Neale, Benjamin M., Ripke, Stephan

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Survey to define informational needs of patients undergoing surgery for Crohn’s anal fistula by Lee, Matthew J., Jones, Georgina L., Lobo, Alan J., Brown, Steven R., Bethune, Robert, Blackmore, Alex, Fearnhead, Nicola, Guy, Richard, Hancock, Laura, Hill, James, Moran, Gordon, Pinkney, Thomas, Verjee, Azmina, Williams, Andrew, Wilson, Timothy

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The Bioburden Associated with Severe Open Tibial Fracture Wounds at the Time of Definitive Closure or Coverage: The BIOBURDEN Study by Major Extremity Trauma Research Consortium (METRC), Major Extremity Trauma Research Consortium (METRC)

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