Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing by Chiou, Shin-Heng, Winters, Ian P, Wang, Jing, Naranjo, Santiago, Dudgeon, Crissy, Tamburini, Fiona B, Brady, Jennifer J, Yang, Dian, Grüner, Barbara M, Chuang, Chen-Hua, Caswell, Deborah R, Zeng, Hong, Chu, Pauline, Kim, Grace E, Carpizo, Darren R, Kim, Seung K, Winslow, Monte M

Get full text

Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity by Winters, Ian P., Chiou, Shin-Heng, Paulk, Nicole K., McFarland, Christopher D., Lalgudi, Pranav V., Ma, Rosanna K., Lisowski, Leszek, Connolly, Andrew J., Petrov, Dmitri A., Kay, Mark A., Winslow, Monte M.

Get full text

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program by Bieging-Rolett, Kathryn T., Kaiser, Alyssa M., Morgens, David W., Boutelle, Anthony M., Seoane, Jose A., Van Nostrand, Eric L., Zhu, Changyu, Houlihan, Shauna L., Mello, Stephano S., Yee, Brian A., McClendon, Jacob, Pierce, Sarah E., Winters, Ian P., Wang, Mengxiong, Connolly, Andrew J., Lowe, Scott W., Curtis, Christina, Yeo, Gene W., Winslow, Monte M., Bassik, Michael C., Attardi, Laura D.

Get full text

Oncogenic context shapes the fitness landscape of tumor suppression by Blair, Lily M., Juan, Joseph M., Sebastian, Lafia, Tran, Vy B., Nie, Wensheng, Wall, Gregory D., Gerceker, Mehmet, Lai, Ian K., Apilado, Edwin A., Grenot, Gabriel, Amar, David, Foggetti, Giorgia, Do Carmo, Mariana, Ugur, Zeynep, Deng, Debbie, Chenchik, Alex, Paz Zafra, Maria, Dow, Lukas E., Politi, Katerina, MacQuitty, Jonathan J., Petrov, Dmitri A., Winslow, Monte M., Rosen, Michael J., Winters, Ian P.

Get full text

An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation by Murray, Christopher W, Brady, Jennifer J, Tsai, Min K, Li, Chuan, Winters, Ian P, Tang, Rui, Andrejka, Laura, Ma, Rosanna K, Kunder, Christian A, Chu, Pauline, Winslow, Monte M

Get full text

RNA interference in marine and freshwater sponges: actin knockdown in Tethya wilhelma and Ephydatia muelleri by ingested dsRNA expressing bacteria by Rivera, Ajna S, Hammel, Jörg U, Haen, Karri M, Danka, Elizabeth S, Cieniewicz, Brandon, Winters, Ian P, Posfai, Dora, Wörheide, Gert, Lavrov, Dennis V, Knight, Scott W, Hill, Malcolm S, Hill, April L, Nickel, Michael

Get full text

Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, in Lung Adenocarcinoma by Caswell, Deborah R, Chuang, Chen-Hua, Ma, Rosanna K, Winters, Ian P, Snyder, Eric L, Winslow, Monte M

Get full text

Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma by Li, Chuan, Lin, Wen-Yang, Rizvi, Hira, Cai, Hongchen, McFarland, Christopher D, Rogers, Zoe N, Yousefi, Maryam, Winters, Ian P, Rudin, Charles M, Petrov, Dmitri A, Winslow, Monte M

Get full text

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors by Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Goldman, Jonathan W., Shaish, Hiram, Katz, Sharyn, Azok, Joseph T., Segal, Jeremy, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Carter, Brett, Roth, Jack A., Swisher, Stephen, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Blumenschein, George R., Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Bivona, Trever G., Leighl, Natasha B., Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Rudin, Charles M., Albacker, Lee, Mann, Helen, Lai, Zhongwu, Peters, Solange, Wong, Kwok K., Huang, Alan, Winslow, Monte M., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip

Get full text

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors by Skoulidis, Ferdinandos, Araujo, Haniel A, Do, Minh Truong, Qian, Yu, Sun, Xin, Cobo, Ana Galan, Le, John T, Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M, Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C, Vokes, Natalie, Schmidt, Stephanie T, Molkentine, David, Owen, Dwight H, Memmott, Regan, Patil, Pradnya D, Marmarelis, Melina E, Awad, Mark M, Murray, Joseph C, Hellyer, Jessica A, Gainor, Justin F, Dimou, Anastasios, Bestvina, Christine M, Shu, Catherine A, Riess, Jonathan W, Blakely, Collin M, Pecot, Chad V, Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan J, Sacher, Adrian G, Lau, Sally C M, Saltos, Andreas N, Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B, Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D, Woodcock, Mark G, Anagnostou, Valsamo, Marrone, Kristen A, Forde, Patrick M, Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer M, Cummings, Amy L, Goldman, Jonathan W, Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph T, Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel W, Lacroix, Ludovic, Elamin, Yasir Y, Negrao, Marcelo V, Le, Xiuning, Lam, Vincent K, Lewis, Whitney E, Kemp, Haley N, Carter, Brett, Roth, Jack A, Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R, Behrens, Carmen, Wistuba, Ignacio I, Zhang, Jianjun, Blumenschein, George R, Gay, Carl, Byers, Lauren A, Gibbons, Don L, Tsao, Anne, Lee, J Jack, Bivona, Trever G, Camidge, D Ross, Gray, Jhannelle E, Leighl, Natasha B, Levy, Benjamin, Brahmer, Julie R, Garassino, Marina C

Get full text

Abstract IA26: Multiplexed functional cancer genomics by Cai, Hongchen, Li, Chuan, Chew, Su Kit, Yousefi, Maryam, Foggetti, Giorgia, Lin, Wen-Yang, Rogers, Zoë N., Winters, Ian P., McFarland, Christopher D., Politi, Katherina, Swanton, Charlie, Petrov, Dmitri A., Winslow, Monte M.

Get full text

Abstract IA03: Functional lung cancer genomics through in vivo genome editing by Winters, Ian P., Rogers, Zoë N., McFarland, Christopher D., Lalgudi, Pranav V., Chiou, Shin-Heng, Kay, Mark A., Petrov, Dmitri, Winslow, Monte M.

Get full text

Abstract 11: Analysis of 30 million tumor time course reveals that inactivating tumor suppressors produces complex gene-specific, time-dependent growth dynamics by Severson, Alissa L., Juan, Joseph, Sebastian, Lafia, Tran, Vy, Nie, Wensheng, Lai, Ian, Wall, Gregory D., Winslow, Monte M., Petrov, Dmitri A., Winters, Ian P., Rosen, Michael J.

Get full text

Abstract 2789: Tumor suppressor genotype dramatically impacts lung cancer response to KRAS G12C inhibitors in vivo by McMurdie, Paul J., Winters, Ian P., Blair, Lily M., Sebastian, Lafia, Tran, Vy, Grenot, Gabriel, Apilado, Edwin A., Lai, Ian K., Wall, Gregory D., Petrov, Dmitri A., Winslow, Monte M., Rosen, Michael J., Juan, Joseph

Get full text

Abstract 5723: An in vivo pharmacogenomics platform replicates and extends biomarkers of therapy response identified via causal inference analysis of clinical data by Amar, David, Scott, Erick, Winters, Ian P., Wall, Gregory D., Petrov, Dmitri A., Winslow, Monte M., Juan, Joseph, Lai, Ian K., Sebastian, Lafia, Apilado, Edwin A., Grenot, Gabriel, Tran, Vy B., Rudin, Charles, Rosen, Michael J.

Get full text

Abstract 1172: Oncogenic context shapes the fitness landscape of tumor suppression by Blair, Lily M., Juan, Joseph M., Sebastian, Lafia, Tran, Vy B., Nie, Wensheng, Wall, Gregory D., Gerceker, Mehmet, Lai, Ian K., Apilado, Edwin A., Grenot, Gabriel, Amar, David, Foggetti, Giorgia, Do Carmo, Mariana, Ugur, Zeynep, Deng, Debbie, Chenchik, Alex, Zafra, Maria Paz, Dow, Lukas E., Politi, Katerina, MacQuitty, Jonathan J., Petrov, Dmitri A., Winslow, Monte M., Rosen, Michael J., Winters, Ian P.

Get full text

RNA interference in marine and freshwater sponges: actin knockdown in Tethya wilhelma and Ephydatia muelleriby ingested dsRNA expressing bacteria by Rivera, Ajna S, Hammel, Jörg U, Haen, Karri M, Danka, Elizabeth S, Cieniewicz, Brandon, Winters, Ian P, Posfai, Dora, Wörheide, Gert, Lavrov, Dennis V, Knight, Scott W, Hill, Malcolm S, Hill, April L, Nickel, Michael

Get full text

RNA interference in marine and freshwater sponges: actin knockdown in Tethya wilhelma and Ephydatia muelleri by ingested dsRNA expressing bacteria by Rivera, Ajna S, Hammel, Jörg U, Haen, Karri M, Danka, Elizabeth S, Cieniewicz, Brandon, Winters, Ian P, Posfai, Dora, Wörheide, Gert, Lavrov, Dennis V, Knight, Scott W, Hill, Malcolm S, Hill, April L, Nickel, Michael

Get full text

RNA interference in marine and freshwater sponges: actin knockdown in Tethya wilhelma and Ephydatia muelleri by ingested dsRNA expressing bacteria by Rivera, Ajna S, Hammel, Jörg U, Haen, Karri M, Danka, Elizabeth S, Cieniewicz, Brandon, Winters, Ian P, Posfai, Dora, Wörheide, Gert, Lavrov, Dennis V, Knight, Scott W, Hill, Malcolm S, Hill, April L, Nickel, Michael

Get full text

275 Candidates and 149 Validated Planets Orbiting Bright Stars in K2 Campaigns 0-10 by Mayo, Andrew W., Vanderburg, Andrew, Latham, David W., Bieryla, Allyson, Morton, Timothy D., Buchhave, Lars A., Dressing, Courtney D., Beichman, Charles, Berlind, Perry, Calkins, Michael L., Ciardi, David R., Crossfield, Ian J. M., Esquerdo, Gilbert A., Everett, Mark E., Gonzales, Erica J., Hirsch, Lea A., Horch, Elliott P., Howard, Andrew W., Howell, Steve B., Livingston, John, Patel, Rahul, Petigura, Erik A., Schlieder, Joshua E., Scott, Nicholas J., Schumer, Clea F., Sinukoff, Evan, Teske, Johanna, Winters, Jennifer G.

Get full text