Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection by Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael

Get full text

A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase by Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, Fisher, Thorsten E., Embrey, Mark, Guare, James P., Egbertson, Melissa S., Vacca, Joseph P., Huff, Joel R., Felock, Peter J., Witmer, Marc V., Stillmock, Kara A., Danovich, Robert, Grobler, Jay, Miller, Michael D., Espeseth, Amy S., Jin, Lixia, I-Wu Chen, Lin, Jiunn H., Kassahun, Kelem, Ellis, Joan D., Wong, Bradley K., Xu, Wei, Pearson, Paul G., Schleif, William A., Cortese, Riccardo, Emini, Emilio, Summa, Vincenzo, Holloway, M. Katharine, Young, Steven D., Coffin, John M.

Get full text

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells by Zhuang, Linghang, Wai, John S, Embrey, Mark W, Fisher, Thorsten E, Egbertson, Melissa S, Payne, Linda S, Guare, James P, Vacca, Joseph P, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Witmer, Marc V, Moyer, Gregory, Schleif, William A, Gabryelski, Lori J, Leonard, Yvonne M, Lynch, Joseph J, Michelson, Stuart R, Young, Steven D

Get full text

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold by Williams, Peter D., Staas, Donnette D., Venkatraman, Shankar, Loughran, H. Marie, Ruzek, Rowena D., Booth, Theresa M., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Feuston, Bradley P., Ecto, Linda T., Flynn, Jessica A., DiStefano, Daniel J., Hazuda, Daria J., Bahnck, Carolyn M., Himmelberger, Amy L., Dornadula, Geetha, Hrin, Renee C., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Grobler, Jay A.

Get full text

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase by Melamed, Jeffrey Y., Egbertson, Melissa S., Varga, Sandor, Vacca, Joseph P., Moyer, Greg, Gabryelski, Lori, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Schleif, William, Hazuda, Daria J., Leonard, Yvonne, Jin, Lixia, Ellis, Joan D., Young, Steven D.

Get full text

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors by Langford, H. Marie, Williams, Peter D., Homnick, Carl F., Vacca, Joseph P., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Hazuda, Daria J., Gabryelski, Lori J., Schleif, William A.

Get full text

10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against... by Wiscount, Catherine M., Williams, Peter D., Tran, Lekhanh O., Embrey, Mark W., Fisher, Thorsten E., Sherman, Vanessa, Homnick, Carl F., Donnette Staas, D., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Wang, ZiQiang, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Hazuda, Daria J., Day, Alysha M., Gabryelski, Lori J., Ecto, Linda T., Schleif, William A., DiStefano, Daniel J., Kochansky, Christopher J., Reza Anari, M.

Get full text

A potent and orally active HIV-1 integrase inhibitor by Egbertson, Melissa S., Moritz, H. Marie, Melamed, Jeffrey Y., Han, Wei, Perlow, Debra S., Kuo, Michelle S., Embrey, Mark, Vacca, Joseph P., Zrada, Matthew M., Cortes, Amanda R., Wallace, Audrey, Leonard, Yvonne, Hazuda, Daria J., Miller, Michael D., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Schleif, William, Gabryelski, Lori J., Moyer, Gregory, Ellis, Joan D., Jin, Lixia, Xu, Wei, Braun, Matthew P., Kassahun, Kellem, Tsou, Nancy N., Young, Steven D.

Get full text

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques by Hazuda, Daria J., Young, Steven D., Guare, James P., Anthony, Neville J., Gomez, Robert P., Wai, John S., Vacca, Joseph P., Handt, Larry, Motzel, Sherri L., Klein, Hilton J., Dornadula, Geethanjali, Danovich, Robert M., Witmer, Marc V., Keith A. A. Wilson, Tussey, Lynda, Schleif, William A., Gabryelski, Lori S., Jin, Lixia, Miller, Michael D., Casimiro, Danilo R., Emini, Emilio A., Shiver, John W.

Get full text

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells by Embrey, Mark W., Wai, John S., Funk, Timothy W., Homnick, Carl F., Perlow, Debbie S., Young, Steven D., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Moyer, Gregory, Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Wong, Bradley K., Lin, Jiunn H., Leonard, Yvonne M., Tsou, Nancy N., Zhuang, Linghang

Get full text

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform by Chen, Z, Yan, Y, Munshi, S, Li, Y, Zugay-Murphy, J, Xu, B, Witmer, M, Felock, P, Wolfe, A, Sardana, V, Emini, E A, Hazuda, D, Kuo, L C

Get full text

Purification, solution properties and crystallization of SIV integrase containing a continuous core and C-terminal domain by Li, Ying, Yan, Youwei, Zugay-Murphy, Joan, Xu, Bei, Cole, James L., Witmer, Marc, Felock, Peter, Wolfe, Abigail, Hazuda, Daria, Sardana, Mohinder K., Chen, Zhongguo, Kuo, Lawrence C., Sardana, Vinod V.

Get full text