Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development by Zaretsky, Serge, Adachi, Shinya, Rotstein, Benjamin H, Hickey, Jennifer L, Scully, Conor C. G, St. Denis, Jeffrey D, Courtemanche, Rebecca, Yu, Joy C. Y, Chung, Benjamin K. W, Yudin, Andrei K

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Twisted amide electrophiles enable cyclic peptide sequencing by Zaretsky, Serge, Rai, Vishal, Gish, Gerald, Forbes, Matthew W, Kofler, Michael, Yu, Joy C Y, Tan, Joanne, Hickey, Jennifer L, Pawson, Tony, Yudin, Andrei K

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Twisted amide electrophiles enable cyclic peptide sequencingElectronic supplementary information (ESI) available: Methods and CID/MS2 analysis. See DOI: 10.1039/c5ob01050k by Zaretsky, Serge, Rai, Vishal, Gish, Gerald, Forbes, Matthew W, Kofler, Michael, Yu, Joy C. Y, Tan, Joanne, Hickey, Jennifer L, Pawson, Tony, Yudin, Andrei K

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Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow by Yu, Vionnie W C, Saez, Borja, Cook, Colleen, Lotinun, Sutada, Pardo-Saganta, Ana, Wang, Ying-Hua, Lymperi, Stefania, Ferraro, Francesca, Raaijmakers, Marc H G P, Wu, Joy Y, Zhou, Lan, Rajagopal, Jayaraj, Kronenberg, Henry M, Baron, Roland, Scadden, David T

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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants by Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J

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Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells by Shaim, Hila, Shanley, Mayra, Basar, Rafet, Daher, May, Gumin, Joy, Zamler, Daniel B., Uprety, Nadima, Wang, Fang, Huang, Yuefan, Gabrusiewicz, Konrad, Miao, Qi, Dou, Jinzhuang, Alsuliman, Abdullah, Kerbauy, Lucila N., Acharya, Sunil, Mohanty, Vakul, Mendt, Mayela, Li, Sufang, Lu, JunJun, Wei, Jun, Fowlkes, Natalie W., Gokdemir, Elif, Ensley, Emily L., Kaplan, Mecit, Kassab, Cynthia, Li, Li, Ozcan, Gonca, Banerjee, Pinaki P., Shen, Yifei, Gilbert, April L., Jones, Corry M., Bdiwi, Mustafa, Nunez-Cortes, Ana K., Liu, Enli, Yu, Jun, Imahashi, Nobuhiko, Muniz-Feliciano, Luis, Li, Ye, Hu, Jian, Draetta, Giulio, Marin, David, Yu, Dihua, Mielke, Stephan, Eyrich, Matthias, Champlin, Richard E., Chen, Ken, Lang, Frederick F., Shpall, Elizabeth J., Heimberger, Amy B., Rezvani, Katayoun

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys by Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu

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Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys by Mackman, Richard L., Kalla, Rao V., Babusis, Darius, Pitts, Jared, Barrett, Kimberly T., Chun, Kwon, Du Pont, Venice, Rodriguez, Lauren, Moshiri, Jasmine, Xu, Yili, Lee, Michael, Lee, Gary, Bleier, Blake, Nguyen, Anh-Quan, O’Keefe, B. Michael, Ambrosi, Andrea, Cook, Meredith, Yu, Joy, Dempah, Kassibla Elodie, Bunyan, Elaine, Riola, Nicholas C., Lu, Xianghan, Liu, Renmeng, Davie, Ashley, Hsiang, Tien-Ying, Dearing, Justin, Vermillion, Meghan, Gale, Michael, Niedziela-Majka, Anita, Feng, Joy Y., Hedskog, Charlotte, Bilello, John P., Subramanian, Raju, Cihlar, Tomas

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Total Synthesis of a Functional Designer Eukaryotic Chromosome by Annaluru, Narayana, Muller, Héloïse, Mitchell, Leslie A., Ramalingam, Sivaprakash, Stracquadanio, Giovanni, Richardson, Sarah M., Dymond, Jessica S., Kuang, Zheng, Scheifele, Lisa Z., Cooper, Eric M., Cai, Yizhi, Zeller, Karen, Agmon, Neta, Han, Jeffrey S., Hadjithomas, Michalis, Tullman, Jennifer, Caravelli, Katrina, Cirelli, Kimberly, Guo, Zheyuan, London, Viktoriya, Yeluru, Apurva, Murugan, Sindurathy, Kandavelou, Karthikeyan, Agier, Nicolas, Fischer, Gilles, Yang, Kun, Martin, Andrew, Bilgel, Murat, Bohutski, Pavlo, Boulier, Kristin M., Capaldo, Brian J., Chang, Joy, Charoen, Kristie, Choi, Woo Jin, Deng, Peter, DiCarlo, James E., Doong, Judy, Dunn, Jessilyn, Feinberg, Jason I., Fernandez, Christopher, Floria, Charlotte E., Gladowski, David, Hadidi, Pasha, Ishizuka, Isabel, Jabbari, Javaneh, Lau, Calvin Y. L., Lee, Pablo A., Li, Sean, Lin, Denise, Linder, Matthias E., Ling, Jonathan, Liu, Jaime, Liu, Jonathan, London, Mariya, Ma, Henry, Mao, Jessica, McDade, Jessica E., McMillan, Alexandra, Moore, Aaron M., Oh, Won Chan, Ouyang, Yu, Patel, Ruchi, Paul, Marina, Paulsen, Laura C., Qiu, Judy, Rhee, Alex, Rubashkin, Matthew G., Soh, Ina Y., Sotuyo, Nathaniel E., Srinivas, Venkatesh, Suarez, Allison, Wong, Andy, Wong, Remus, Xie, Wei Rose, Xu, Yijie, Yu, Allen T., Koszul, Romain, Bader, Joel S., Boeke, Jef D., Chandrasegaran, Srinivasan

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Quaternary time scales for the Pontocaspian domain: Interbasinal connectivity and faunal evolution by Krijgsman, W., Tesakov, A., Yanina, T., Lazarev, S., Danukalova, G., Van Baak, C.G.C., Agustí, J., Alçiçek, M.C., Aliyeva, E., Bista, D., Bruch, A., Büyükmeriç, Y., Bukhsianidze, M., Flecker, R., Frolov, P., Hoyle, T.M., Jorissen, E.L., Kirscher, U., Koriche, S.A., Kroonenberg, S.B., Lordkipanidze, D., Oms, O., Rausch, L., Singarayer, J., Stoica, M., van de Velde, S., Titov, V.V., Wesselingh, F.P.

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A Pilot Randomized Controlled Trial to Decrease Adaptation Difficulties in Chinese New Immigrants to Hong Kong by Yu, Xiaonan, Stewart, Sunita M, Chui, Jolian P.L, Ho, Joy L.Y, Li, Anthony C.H, Lam, Tai Hing

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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models by van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E., Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M., Beumers, Philipp, Capell, Anja, Davis, Sonnet S., de Weerd, Lis, Dugas, Jason C., Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T., Kunze, Lea H., Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O., Nguyen, Hoang N., Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H., Thorne, Robert G., Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y. Joy Yu, Diaz, Dolo, Dennis, Mark S., Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J., Haass, Christian, Lewcock, Joseph W., Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E., Monroe, Kathryn M.

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus by Gilmore, Sarah A, Tam, Danny, Cheung, Tara L, Snyder, Chelsea, Farand, Julie, Dick, Ryan, Matles, Mike, Feng, Joy Y, Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M, Appleby, Todd C, Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H, Delaney, 4th, William E, Notte, Gregory T, Schmitz, Uli, Feierbach, Becket

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier by Barker, Scarlett J, Thayer, Mai B, Kim, Chaeyoung, Tatarakis, David, Simon, Matthew J, Dial, Rebekah, Nilewski, Lizanne, Wells, Robert C, Zhou, Yinhan, Afetian, Megan, Akkapeddi, Padma, Chappell, Alfred, Chew, Kylie S, Chow, Johann, Clemens, Allisa, Discenza, Claire B, Dugas, Jason C, Dwyer, Chrissa, Earr, Timothy, Ha, Connie, Ho, Yvonne S, Huynh, David, Lozano, Edwin I, Jayaraman, Srini, Kwan, Wanda, Mahon, Cathal, Pizzo, Michelle, Robles-Colmenares, Yaneth, Roche, Elysia, Sanders, Laura, Stergioulis, Alexander, Tong, Raymond, Tran, Hai, Zuchero, Y, Estrada, Anthony A, Gadkar, Kapil, Koth, Christopher M M, Sanchez, Pascal E, Thorne, Robert G, Watts, Ryan J, Sandmann, Thomas, Kane, Lesley A, Rigo, Frank, Dennis, Mark S, Lewcock, Joseph W, DeVos, Sarah L

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus by Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach

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Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors by Wu, Zhaoju, Chang, Pei-Ching, Yang, Joy C, Chu, Cheng-Ying, Wang, Ling-Yu, Chen, Nien-Tsu, Ma, Ai-Hong, Desai, Sonal J, Lo, Su Hao, Evans, Christopher P, Lam, Kit S, Kung, Hsing-Jien

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Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array by Matsuzaki, Hajime, Loi, Halina, Dong, Shoulian, Tsai, Ya-Yu, Fang, Joy, Law, Jane, Di, Xiaojun, Liu, Wei-Min, Yang, Geoffrey, Liu, Guoying, Huang, Jing, Kennedy, Giulia C, Ryder, Thomas B, Marcus, Gregory A, Walsh, P Sean, Shriver, Mark D, Puck, Jennifer M, Jones, Keith W, Mei, Rui

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Three-dimensional microstructural mapping of poisoning phases in the Neodymium Nickelate solid oxide fuel cell cathode by Harris, William M., Lombardo, Jeffrey J., DeGostin, Matthew B., Nelson, George J., Luebbe, Henning, Schuler, J. Andreas, Van herle, Jan, Andrews, Joy C., Liu, Yijin, Pianetta, Piero, Karen Chen, Yu-Chen, Wang, Jun, Chiu, Wilson K.S.

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Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge by Kim, Soo-Ki, Kim, Jae-Heon, Kim, Cheol-Su, Ignacio, Rosa Mistica, Kim, Dong-Heui, Sajo, Ma. Easter Joy, Meang, Eun-Ho, Qi, Xu-Feng, Park, Seong-Eun, Kim, Yu-Ri, Kim, Myeong-Kon, Lee, Kyu-Jae, An, Seong Soo A.

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Pharmacokinetics and Exposure–Response Analyses of Daratumumab in Combination Therapy Regimens for Patients with Multiple Myeloma by Xu, Xu Steven, Dimopoulos, Meletios A., Sonneveld, Pieter, Ho, P. Joy, Belch, Andrew, Leiba, Merav, Capra, Marcelo, Gomez, David, Medvedova, Eva, Iida, Shinsuke, Min, Chang-Ki, Schecter, Jordan, Jansson, Richard, Zhang, Liping, Sun, Yu-Nien, Clemens, Pamela L.

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