Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay by Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sébastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phil B, Michellys, Pierre-Yves, Deane, Jonathan, Junt, Tobias, Zipfel, Géraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases by Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves

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Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist by Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, René, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sébastien, Junt, Tobias, Zipfel, Géraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

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Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy by Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

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Anti-Melanocortin-4 Receptor Autoantibodies in Obesity by Peter, Jean-Christophe, Bekel, Akkiz, Lecourt, Anne-Catherine, Zipfel, Géraldine, Eftekhari, Pierre, Nesslinger, Maya, Breidert, Matthias, Muller, Sylviane, Kessler, Laurence, Hofbauer, Karl G.

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A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration by Peter, Jean-Christophe, Lecourt, Anne-Catherine, Weckering, Marjorie, Zipfel, Géraldine, Niehoff, Michael L, Banks, William A, Hofbauer, Karl G

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Protective effects of an anti-melanocortin-4 receptor scFv derivative in lipopolysaccharide-induced cachexia in rats by Peter, Jean-Christophe, Rossez, Hélène, Weckering, Marjorie, Zipfel, Géraldine, Lecourt, Anne-Catherine, Owen, Joshua B., Banks, William A., Hofbauer, Karl G.

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway by Alper, Phil B., Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Géraldine, Gordon, Perry, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, McKeever, Una, Michellys, Pierre-Yves, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James S., Syka, Peter, Zhang, Yi, Zhu, Xuefeng

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Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats by Peter, Jean-Christophe, Zipfel, Géraldine, Lecourt, Anne-Catherine, Bekel, Akkiz, Hofbauer, Karl G.

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Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants by Hoyler, Thomas, Bannert, Bettina, André, Cédric, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James S., Ruzzante, Giulia, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias

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