Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial by Grieco, Domenico Luca, Menga, Luca S, Cesarano, Melania, Rosà, Tommaso, Spadaro, Savino, Bitondo, Maria Maddalena, Montomoli, Jonathan, Falò, Giulia, Tonetti, Tommaso, Cutuli, Salvatore L, Pintaudi, Gabriele, Tanzarella, Eloisa S, Piervincenzi, Edoardo, Bongiovanni, Filippo, Dell’Anna, Antonio M, Delle Cese, Luca, Berardi, Cecilia, Carelli, Simone, Bocci, Maria Grazia, Montini, Luca, Bello, Giuseppe, Natalini, Daniele, De Pascale, Gennaro, Velardo, Matteo, Volta, Carlo Alberto, Ranieri, V. Marco, Conti, Giorgio, Maggiore, Salvatore Maurizio, Antonelli, Massimo

Vaginal microbiome: normalcy vs dysbiosis by Saraf, Viqar Sayeed, Sheikh, Sohail Aslam, Ahmad, Aftab, Gillevet, Patrick M., Bokhari, Habib, Javed, Sundus

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial by Dahl, Dominik, Onishi, Yukiko, Norwood, Paul, Huh, Ruth, Bray, Ross, Patel, Hiren, Rodríguez, Ángel

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial by Rosenstock, Julio, Perkovic, Vlado, Johansen, Odd Erik, Cooper, Mark E, Kahn, Steven E, Marx, Nikolaus, Alexander, John H, Pencina, Michael, Toto, Robert D, Wanner, Christoph, Zinman, Bernard, Woerle, Hans Juergen, Baanstra, David, Pfarr, Egon, Schnaidt, Sven, Meinicke, Thomas, George, Jyothis T, von Eynatten, Maximilian, McGuire, Darren K

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial by Harris, Patrick N. A, Tambyah, Paul A, Lye, David C, Mo, Yin, Lee, Tau H, Yilmaz, Mesut, Alenazi, Thamer H, Arabi, Yaseen, Falcone, Marco, Bassetti, Matteo, Righi, Elda, Rogers, Benjamin A, Kanj, Souha, Bhally, Hasan, Iredell, Jon, Mendelson, Marc, Boyles, Tom H, Looke, David, Miyakis, Spiros, Walls, Genevieve, Al Khamis, Mohammed, Zikri, Ahmed, Crowe, Amy, Ingram, Paul, Daneman, Nick, Griffin, Paul, Athan, Eugene, Lorenc, Penelope, Baker, Peter, Roberts, Leah, Beatson, Scott A, Peleg, Anton Y, Harris-Brown, Tiffany, Paterson, David L

Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial by van de Graaf, Victor A, Noorduyn, Julia C. A, Willigenburg, Nienke W, Butter, Ise K, de Gast, Arthur, Mol, Ben W, Saris, Daniel B. F, Twisk, Jos W. R, Poolman, Rudolf W

Endoscopic Transgastric vs Surgical Necrosectomy for Infected Necrotizing Pancreatitis: A Randomized Trial by Bakker, Olaf J, van Santvoort, Hjalmar C, van Brunschot, Sandra, Geskus, Ronald B, Besselink, Marc G, Bollen, Thomas L, van Eijck, Casper H, Fockens, Paul, Hazebroek, Eric J, Nijmeijer, Rian M, Poley, Jan-Werner, van Ramshorst, Bert, Vleggaar, Frank P, Boermeester, Marja A, Gooszen, Hein G, Weusten, Bas L, Timmer, Robin, Dutch Pancreatitis Study Group, for the

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial by Bennell, Kim L, Paterson, Kade L, Metcalf, Ben R, Duong, Vicky, Eyles, Jillian, Kasza, Jessica, Wang, Yuanyuan, Cicuttini, Flavia, Buchbinder, Rachelle, Forbes, Andrew, Harris, Anthony, Yu, Shirley P, Connell, David, Linklater, James, Wang, Bing Hui, Oo, Win Min, Hunter, David J

Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial by Kim, Byeong-Keuk, Hong, Sung-Jin, Cho, Yun-Hyeong, Yun, Kyeong Ho, Kim, Yong Hoon, Suh, Yongsung, Cho, Jae Young, Her, Ae-Young, Cho, Sungsoo, Jeon, Dong Woon, Yoo, Sang-Yong, Cho, Deok-Kyu, Hong, Bum-Kee, Kwon, Hyuckmoon, Ahn, Chul-Min, Shin, Dong-Ho, Nam, Chung-Mo, Kim, Jung-Sun, Ko, Young-Guk, Choi, Donghoon, Hong, Myeong-Ki, Jang, Yangsoo

Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial by Tap, William D, Wagner, Andrew J, Schöffski, Patrick, Martin-Broto, Javier, Krarup-Hansen, Anders, Ganjoo, Kristen N, Yen, Chueh-Chuan, Abdul Razak, Albiruni R, Spira, Alexander, Kawai, Akira, Le Cesne, Axel, Van Tine, Brian A, Naito, Yoichi, Park, Se Hoon, Fedenko, Alexander, Pápai, Zsuzsanna, Soldatenkova, Victoria, Shahir, Ashwin, Mo, Gary, Wright, Jennifer, Jones, Robin L

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial by McAlindon, Timothy E, LaValley, Michael P, Harvey, William F, Price, Lori Lyn, Driban, Jeffrey B, Zhang, Ming, Ward, Robert J

WATER: A Double-Blind, Randomized, Controlled Trial of Aquablation® vs Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia by Gilling, Peter, Barber, Neil, Bidair, Mohamed, Anderson, Paul, Sutton, Mark, Aho, Tev, Kramolowsky, Eugene, Thomas, Andrew, Cowan, Barrett, Kaufman, Ronald P., Trainer, Andrew, Arther, Andrew, Badlani, Gopal, Plante, Mark, Desai, Mihir, Doumanian, Leo, Te, Alexis E., DeGuenther, Mark, Roehrborn, Claus

Natural vs. Synthetic Zeolites by Krol, Magdalena

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial by Dulhunty, Joel M, Brett, Stephen J, De Waele, Jan J, Rajbhandari, Dorrilyn, Billot, Laurent, Cotta, Menino O, Davis, Joshua S, Finfer, Simon, Hammond, Naomi E, Knowles, Serena, Liu, Xiaoqiu, McGuinness, Shay, Mysore, Jayanthi, Paterson, David L, Peake, Sandra, Rhodes, Andrew, Roberts, Jason A, Roger, Claire, Shirwadkar, Charudatt, Starr, Therese, Taylor, Colman, Myburgh, John A, Lipman, Jeffrey

Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial by Mentz, Robert J, Anstrom, Kevin J, Eisenstein, Eric L, Sapp, Shelly, Greene, Stephen J, Morgan, Shelby, Testani, Jeffrey M, Harrington, Amanda H, Sachdev, Vandana, Ketema, Fassil, Kim, Dong-Yun, Desvigne-Nickens, Patrice, Pitt, Bertram, Velazquez, Eric J

SMOFlipid vs Intralipid 20%: Effect of Mixed‐Oil vs Soybean‐Oil Emulsion on Parenteral Nutrition–Associated Cholestasis in the Neonatal Population by Jackson, Rachel Leigh, White, Phillip Zachary, Zalla, Jennifer

Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial by Gao, Peng, Wang, Tao, Wang, Daming, Liebeskind, David S., Shi, Huaizhang, Li, Tianxiao, Zhao, Zhenwei, Cai, Yiling, Wu, Wei, He, Weiwen, Yu, Jia, Zheng, Bingjie, Wang, Haibo, Wu, Yangfeng, Dmytriw, Adam A., Krings, Timo, Derdeyn, Colin P., Jiao, Liqun, Jiao, Liqun, Wang, Daming, Krings, Timo, Libeskind, David S, Shi, Huaizhang, Li, Tianxiao, Zhao, Zhenwei, Wu, Wei, Cai, Yiling, He, Weiwen, Huang, Shengping, Yin, Long, Gu, Yuxiang, Zhang, Hongqi, Ling, Feng, Caplan, Louis R., Zaidat, Osama, YU, Simon Chun Ho, Sun, Qinjian, Lu, Jie, Bao, Yuhai, Yang, Kun, Song, Haiqing, Chen, Wenhuo, Chi, Haitao, Wang, Shouchun, Zhang, Jin, Chen, Fei, Li, Shenmao, Zhang, Xiaobo, Sui, Hong, Hu, Weiwu, Li, Long, Feng, Yao, Gao, Peng, Wang, Tao, Wang, Haibo, Zhu, Yidan, Zheng, Bingjie, Qi, Peng, Chen, Kunpeng, He, Yingkun, Yu, Jia, Gong, Weigang, Du, Juan, Cui, Yongqiang, Chen, Yachong

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial by Taccone, Fabio Silvio, Rynkowski, Carla Bittencourt, Møller, Kirsten, Lormans, Piet, Quintana-Díaz, Manuel, Caricato, Anselmo, Cardoso Ferreira, Marco Antonio, Badenes, Rafael, Kurtz, Pedro, Søndergaard, Christian Baastrup, Colpaert, Kirsten, Petterson, Leticia, Quintard, Herve, Cinotti, Raphael, Gouvêa Bogossian, Elisa, Righy, Cassia, Silva, Serena, Roman-Pognuz, Erik, Vandewaeter, Catherine, Lemke, Daniel, Huet, Olivier, Mahmoodpoor, Ata, Blandino Ortiz, Aaron, van der Jagt, Mathieu, Chabanne, Russell, Videtta, Walter, Bouzat, Pierre, Vincent, Jean-Louis

Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial by Locatelli, Franco, Zugmaier, Gerhard, Rizzari, Carmelo, Morris, Joan D, Gruhn, Bernd, Klingebiel, Thomas, Parasole, Rosanna, Linderkamp, Christin, Flotho, Christian, Petit, Arnaud, Micalizzi, Concetta, Mergen, Noemi, Mohammad, Abeera, Kormany, William N, Eckert, Cornelia, Möricke, Anja, Sartor, Mary, Hrusak, Ondrej, Peters, Christina, Saha, Vaskar, Vinti, Luciana, von Stackelberg, Arend

Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial by Jayne, David, Pigazzi, Alessio, Marshall, Helen, Croft, Julie, Corrigan, Neil, Copeland, Joanne, Quirke, Phil, West, Nick, Rautio, Tero, Thomassen, Niels, Tilney, Henry, Gudgeon, Mark, Bianchi, Paolo Pietro, Edlin, Richard, Hulme, Claire, Brown, Julia