CpCoIII-Catalyzed Dehydrative C–H Allylation of 6‑Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols

Cp*CoIII-catalyzed C–H allylation of various aromatic C–H bonds using allyl alcohols as allylating reagents is described. Improved reaction conditions using fluorinated alcohol solvents afforded efficient directed C–H allylation of 6-arylpurines, benzamides, and a synthetically useful Weinreb amide...

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Bibliographic Details
Published in:Organic letters 2016-05, Vol.18 (9), p.2216-2219
Main Authors: Bunno, Youka, Murakami, Nanami, Suzuki, Yudai, Kanai, Motomu, Yoshino, Tatsuhiko, Matsunaga, Shigeki
Format: Article
Language:eng ; jpn
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Summary:Cp*CoIII-catalyzed C–H allylation of various aromatic C–H bonds using allyl alcohols as allylating reagents is described. Improved reaction conditions using fluorinated alcohol solvents afforded efficient directed C–H allylation of 6-arylpurines, benzamides, and a synthetically useful Weinreb amide with good functional group compatibility.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b00846