Supramolecular Nanocarrier of siRNA from PEG-Based Block Catiomer Carrying Diamine Side Chain with Distinctive pK a Directed To Enhance Intracellular Gene Silencing

An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pK a values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allow...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-10, Vol.126 (42), p.13612-13613
Main Authors: Itaka, Keiji, Kanayama, Naoki, Nishiyama, Nobuhiro, Jang, Woo-Dong, Yamasaki, Yuichi, Nakamura, Kozo, Kawaguchi, Hiroshi, Kataoka, Kazunori
Format: Article
Language:English
Online Access:Get full text
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Summary:An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pK a values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja047174r