CSA-Enabled Spin Diffusion Leads to MAS Rate-Dependent T 1’s at High Field

A surprisingly strong spin rate dependence of 15N and 13C NMR T 1 times in magic angle spinning experiments on solid peptides is demonstrated. Using a variety of isotopomers, the phenomenon is shown to be the result of chemical shift anisotropy-mediated spin diffusion. This effect has the potential...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2011-02, Vol.133 (5), p.1156-1158
Main Authors: Fry, Elizabeth A, Sengupta, Suvrajit, Phan, Van C, Kuang, Shan, Zilm, Kurt W
Format: Article
Language:English
Online Access:Get full text
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Summary:A surprisingly strong spin rate dependence of 15N and 13C NMR T 1 times in magic angle spinning experiments on solid peptides is demonstrated. Using a variety of isotopomers, the phenomenon is shown to be the result of chemical shift anisotropy-mediated spin diffusion. This effect has the potential to be used to detect long-range distance constraints in macromolecular systems.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja106730p