Sulfonylation of Five-Membered Heterocycles via an SNAr Reaction

An efficient, concise, and transition metal-free synthesis of functionalized sulfonylated five-membered heterocyclic compounds via an SNAr reaction has been developed. Using commercially available sodium sulfinates as sulfonylation reagents, various five-membered heterocyclic sulfones were obtained...

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Bibliographic Details
Published in:Journal of organic chemistry 2013-12, Vol.78 (23), p.11874-11880
Main Authors: Liang, Shuai, Zhang, Ruo-Yi, Xi, Long-Yi, Chen, Shan-Yong, Yu, Xiao-Qi
Format: Article
Language:English
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Summary:An efficient, concise, and transition metal-free synthesis of functionalized sulfonylated five-membered heterocyclic compounds via an SNAr reaction has been developed. Using commercially available sodium sulfinates as sulfonylation reagents, various five-membered heterocyclic sulfones were obtained in good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo401828b