New Applications of Bis(oxazoline) Ligands in Catalysis:  Asymmetric 1,2- and 1,4-Addition of ZnR2 to Carbonyl Compounds

The enantioselective addition of ZnR2 to aldehydes (1,2) and cyclic enones (1,4) was accomplished using bis(oxazolines) as chiral ligands. The requirement for hydroxymethylene side chains in the ligands strongly suggests that bimetallic catalysts are decisive for high enantiocontrol in these additio...

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Bibliographic Details
Published in:Organic letters 2001-12, Vol.3 (26), p.4259-4262
Main Authors: Schinnerl, Marina, Seitz, Michael, Kaiser, Anja, Reiser, Oliver
Format: Article
Language:English
Online Access:Get full text
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Summary:The enantioselective addition of ZnR2 to aldehydes (1,2) and cyclic enones (1,4) was accomplished using bis(oxazolines) as chiral ligands. The requirement for hydroxymethylene side chains in the ligands strongly suggests that bimetallic catalysts are decisive for high enantiocontrol in these additions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol016925g