A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp3 C−H Functionalization

A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp3 C−H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.

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Bibliographic Details
Published in:Organic letters 2010-06, Vol.12 (12), p.2841-2843
Main Authors: Zhang, Jintang, Zhu, Dapeng, Yu, Chenmin, Wan, Changfeng, Wang, Zhiyong
Format: Article
Language:eng ; jpn
Online Access:Get full text
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Summary:A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp3 C−H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100954x