Evidence that behavioral depression does not influence airway cell influx in allergic rats

THIS study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electri...

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Bibliographic Details
Published in:Mediators of Inflammation 2001-12, Vol.2001, p.229-232
Main Authors: Marcos A. Varriano, Ana A. Varriano, Fernanda Datti, Marcelo Datti, Edson Antunes, Nancy A. Teixeira
Format: Article
Language:English
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Summary:THIS study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applied on day 0, 7 and 13 after OVA sensitization, was used as a model to induce depression. In both nondepressed and depressed groups, the number of total and differential cells (eosinophils and mononuclear cells) in BAL fluid was significantly larger in sensitized compared with non-sensitized animals. However, no statistical differences were found between these groups with respect to the number of total and differential leukocytes, irrespective of the day inescapable shock was applied. Thus, behavioral depression does not influence the pattern of cell infiltration into the airways of allergen-induced airway inflammation.
ISSN:0962-9351
DOI:10.1080/09629350120080438