The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance

Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study t...

Full description

Saved in:
Bibliographic Details
Published in:Oman medical journal 2018-09, Vol.33 (5), p.401-408
Main Authors: Srivastava , Neena, Mittal , Balraj, Srivastava , Apurva, Prakash , Jai, Awasthi , Shally
Format: Article
Language:English
Subjects:
DIABETES
Diabetes Mellitus
GENES
Genetic
INDIA
INSULIN
Insulin Resistance
LIPOPROTEIN LIPASE
Obesity
Original
OVERWEIGHT
POLYMORPHISM
VARIANTS
الإنسولين
الجينات
المغايرات
الهند
تعدد الأشكال
فرط الوزن
ليباز البروتينات الشحمية
مرض السكر
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR. Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2018.74