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The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance
Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study t...
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| Published in: | Oman medical journal 2018-09, Vol.33 (5), p.401-408 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 408 |
| container_issue | 5 |
| container_start_page | 401 |
| container_title | Oman medical journal |
| container_volume | 33 |
| creator | Srivastava , Neena Mittal , Balraj Srivastava , Apurva Prakash , Jai Awasthi , Shally |
| description | Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified
clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The
lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.
We performed a case-control study to determine the association between LPL gene
polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).
Methods: We examined the different LPL gene variants for association in 642 individuals
segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene
polymorphisms were analyzed using polymerase chain reaction-restriction fragment
length polymorphism. Results: A substantial association was observed for -93 gene
polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism
showed association with IR. Conclusions: We found a significant association between
-93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated
phenotypes in the studied population. |
| doi_str_mv | 10.5001/omj.2018.74 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_alman</sourceid><recordid>TN_cdi_almanhal_primary_128545</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e539ceb98cd04ddaa482d5a280d7395a</doaj_id><sourcerecordid>2103684430</sourcerecordid><originalsourceid>FETCH-LOGICAL-a4074-4d315e7e017665cf20526a81b44bf3201d9d64345aa9b8fdd86a7df58d5f5eee3</originalsourceid><addsrcrecordid>eNpVkl1v0zAUhiMEYtXYFdcgXyJBij8T-wZpmmBUqrRpGog76yQ-WV0lcbFTUP8BPxuXjqrzja3Xjx5_nFMUrxmdK0rZxzCs55wyPa_ls2LGaU1Lxal8XsyYMaasK_3jrLhIaU3zEIYbwV8WZ4JyRmtmZsWf-xWSy5RC62HyYSShI0DuICL5DtHDOO2T0ogPpFSC3MYwhAkjucYRyW3od0OIm5VPQ9pzS78Jm5gBP-7XkPAA_vbTitw0mPy0IzA6shjTts_QXY7SBGOLr4oXHfQJLx7n8-Lbl8_3V1_L5c314upyWYKktSylE0xhjZTVVaXajlPFK9CskbLpRP4JZ1wlhVQAptGdc7qC2nVKO9UpRBTnxeLgdQHWdhP9AHFnA3j7LwjxwUKcfNujRSVMi43RraPSOQCpuVPANXW1MAqy69PBtdk2A7oWxylC_0T6dGf0K_sQftmKCWY4y4J3j4IYfm4xTXbwqcW-hxHDNtlcJVFpKQXN6PsD2saQUsTueAyjdt8KNreC3beCrWWm357e7Mj-L3wG3hwAzDl2cCQM5YqeCKAfYFydvIpxraQSfwHVGsPm</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2103684430</pqid></control><display><type>article</type><title>The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance</title><source>PubMed Central</source><creator>Srivastava , Neena ; Mittal , Balraj ; Srivastava , Apurva ; Prakash , Jai ; Awasthi , Shally</creator><creatorcontrib>Srivastava , Neena ; Mittal , Balraj ; Srivastava , Apurva ; Prakash , Jai ; Awasthi , Shally</creatorcontrib><description>Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified
clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The
lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.
We performed a case-control study to determine the association between LPL gene
polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).
Methods: We examined the different LPL gene variants for association in 642 individuals
segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene
polymorphisms were analyzed using polymerase chain reaction-restriction fragment
length polymorphism. Results: A substantial association was observed for -93 gene
polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism
showed association with IR. Conclusions: We found a significant association between
-93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated
phenotypes in the studied population.</description><identifier>ISSN: 1999-768X</identifier><identifier>EISSN: 2070-5204</identifier><identifier>DOI: 10.5001/omj.2018.74</identifier><identifier>PMID: 30210719</identifier><language>eng</language><publisher>Muscat - Oman: Oman Medical Specialty Board</publisher><subject>DIABETES ; Diabetes Mellitus ; GENES ; Genetic ; INDIA ; INSULIN ; Insulin Resistance ; LIPOPROTEIN LIPASE ; Obesity ; Original ; OVERWEIGHT ; POLYMORPHISM ; VARIANTS ; الإنسولين ; الجينات ; المغايرات ; الهند ; تعدد الأشكال ; فرط الوزن ; ليباز البروتينات الشحمية ; مرض السكر</subject><ispartof>Oman medical journal, 2018-09, Vol.33 (5), p.401-408</ispartof><rights>The OMJ is Published Bimonthly and Copyrighted 2018 by the OMSB. 2018 Oman Medical Specialty Board</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a4074-4d315e7e017665cf20526a81b44bf3201d9d64345aa9b8fdd86a7df58d5f5eee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://static.almanhal.com/covers/titl/128545/cover-lg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131921/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131921/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30210719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srivastava , Neena</creatorcontrib><creatorcontrib>Mittal , Balraj</creatorcontrib><creatorcontrib>Srivastava , Apurva</creatorcontrib><creatorcontrib>Prakash , Jai</creatorcontrib><creatorcontrib>Awasthi , Shally</creatorcontrib><title>The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance</title><title>Oman medical journal</title><addtitle>Oman Med J</addtitle><description>Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified
clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The
lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.
We performed a case-control study to determine the association between LPL gene
polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).
Methods: We examined the different LPL gene variants for association in 642 individuals
segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene
polymorphisms were analyzed using polymerase chain reaction-restriction fragment
length polymorphism. Results: A substantial association was observed for -93 gene
polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism
showed association with IR. Conclusions: We found a significant association between
-93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated
phenotypes in the studied population.</description><subject>DIABETES</subject><subject>Diabetes Mellitus</subject><subject>GENES</subject><subject>Genetic</subject><subject>INDIA</subject><subject>INSULIN</subject><subject>Insulin Resistance</subject><subject>LIPOPROTEIN LIPASE</subject><subject>Obesity</subject><subject>Original</subject><subject>OVERWEIGHT</subject><subject>POLYMORPHISM</subject><subject>VARIANTS</subject><subject>الإنسولين</subject><subject>الجينات</subject><subject>المغايرات</subject><subject>الهند</subject><subject>تعدد الأشكال</subject><subject>فرط الوزن</subject><subject>ليباز البروتينات الشحمية</subject><subject>مرض السكر</subject><issn>1999-768X</issn><issn>2070-5204</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkl1v0zAUhiMEYtXYFdcgXyJBij8T-wZpmmBUqrRpGog76yQ-WV0lcbFTUP8BPxuXjqrzja3Xjx5_nFMUrxmdK0rZxzCs55wyPa_ls2LGaU1Lxal8XsyYMaasK_3jrLhIaU3zEIYbwV8WZ4JyRmtmZsWf-xWSy5RC62HyYSShI0DuICL5DtHDOO2T0ogPpFSC3MYwhAkjucYRyW3od0OIm5VPQ9pzS78Jm5gBP-7XkPAA_vbTitw0mPy0IzA6shjTts_QXY7SBGOLr4oXHfQJLx7n8-Lbl8_3V1_L5c314upyWYKktSylE0xhjZTVVaXajlPFK9CskbLpRP4JZ1wlhVQAptGdc7qC2nVKO9UpRBTnxeLgdQHWdhP9AHFnA3j7LwjxwUKcfNujRSVMi43RraPSOQCpuVPANXW1MAqy69PBtdk2A7oWxylC_0T6dGf0K_sQftmKCWY4y4J3j4IYfm4xTXbwqcW-hxHDNtlcJVFpKQXN6PsD2saQUsTueAyjdt8KNreC3beCrWWm357e7Mj-L3wG3hwAzDl2cCQM5YqeCKAfYFydvIpxraQSfwHVGsPm</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Srivastava , Neena</creator><creator>Mittal , Balraj</creator><creator>Srivastava , Apurva</creator><creator>Prakash , Jai</creator><creator>Awasthi , Shally</creator><general>Oman Medical Specialty Board</general><general>OMJ</general><scope>~6Z</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180901</creationdate><title>The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance</title><author>Srivastava , Neena ; Mittal , Balraj ; Srivastava , Apurva ; Prakash , Jai ; Awasthi , Shally</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a4074-4d315e7e017665cf20526a81b44bf3201d9d64345aa9b8fdd86a7df58d5f5eee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>DIABETES</topic><topic>Diabetes Mellitus</topic><topic>GENES</topic><topic>Genetic</topic><topic>INDIA</topic><topic>INSULIN</topic><topic>Insulin Resistance</topic><topic>LIPOPROTEIN LIPASE</topic><topic>Obesity</topic><topic>Original</topic><topic>OVERWEIGHT</topic><topic>POLYMORPHISM</topic><topic>VARIANTS</topic><topic>الإنسولين</topic><topic>الجينات</topic><topic>المغايرات</topic><topic>الهند</topic><topic>تعدد الأشكال</topic><topic>فرط الوزن</topic><topic>ليباز البروتينات الشحمية</topic><topic>مرض السكر</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srivastava , Neena</creatorcontrib><creatorcontrib>Mittal , Balraj</creatorcontrib><creatorcontrib>Srivastava , Apurva</creatorcontrib><creatorcontrib>Prakash , Jai</creatorcontrib><creatorcontrib>Awasthi , Shally</creatorcontrib><collection>Al Manhal All Journals Collection</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Oman medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srivastava , Neena</au><au>Mittal , Balraj</au><au>Srivastava , Apurva</au><au>Prakash , Jai</au><au>Awasthi , Shally</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance</atitle><jtitle>Oman medical journal</jtitle><addtitle>Oman Med J</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>33</volume><issue>5</issue><spage>401</spage><epage>408</epage><pages>401-408</pages><issn>1999-768X</issn><eissn>2070-5204</eissn><abstract>Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified
clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The
lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.
We performed a case-control study to determine the association between LPL gene
polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).
Methods: We examined the different LPL gene variants for association in 642 individuals
segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene
polymorphisms were analyzed using polymerase chain reaction-restriction fragment
length polymorphism. Results: A substantial association was observed for -93 gene
polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism
showed association with IR. Conclusions: We found a significant association between
-93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated
phenotypes in the studied population.</abstract><cop>Muscat - Oman</cop><pub>Oman Medical Specialty Board</pub><pmid>30210719</pmid><doi>10.5001/omj.2018.74</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1999-768X |
| ispartof | Oman medical journal, 2018-09, Vol.33 (5), p.401-408 |
| issn | 1999-768X 2070-5204 |
| language | eng |
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| source | PubMed Central |
| subjects | DIABETES Diabetes Mellitus GENES Genetic INDIA INSULIN Insulin Resistance LIPOPROTEIN LIPASE Obesity Original OVERWEIGHT POLYMORPHISM VARIANTS الإنسولين الجينات المغايرات الهند تعدد الأشكال فرط الوزن ليباز البروتينات الشحمية مرض السكر |
| title | The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance |
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