DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids

Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, a...

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Bibliographic Details
Published in:Annual review of analytical chemistry (Palo Alto, Calif.) Calif.), 2018-06, Vol.11 (1), p.197-218
Main Author: Ferapontova, Elena E
Format: Article
Language:English
Subjects:
Beverages
Biosensing Techniques
Catalysis
Chemical reactions
Chemical sensors
Contamination
Deoxyribonucleic acid
DNA
DNA - analysis
DNA-mediated electron transfer
electrocatalytic sensors
electrochemical beacons
electrochemical DNA biosensors
Electrochemical Techniques
Electrochemistry
Electrodes
Environmental science
Food contamination
Genetic modification
Genetically engineered organisms
Genetically modified organisms
Humans
hybridization
Nucleic acids
Oxidation-Reduction
redox indicators
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Description
Summary:Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed.
ISSN:1936-1327
1936-1335
DOI:10.1146/annurev-anchem-061417-125811