Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species

A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical s...

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Bibliographic Details
Published in:Annual review of analytical chemistry (Palo Alto, Calif.) Calif.), 2017-06, Vol.10 (1), p.225-246
Main Authors: Yoshinobu, Tatsuo, Miyamoto, Ko-ichiro, Werner, Carl Frederik, Poghossian, Arshak, Wagner, Torsten, Schöning, Michael J
Format: Article
Language:English
Subjects:
bioimaging
biosensor
chemical imaging sensor
Chemical sensors
Chemical speciation
Imaging
Infrared imaging systems
Instrumentation
LAPS
Light
Materials science
Microfluidics
pH sensor
Sensors
Spatial discrimination
Spatial distribution
Spatial resolution
State-of-the-art reviews
Technology
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Description
Summary:A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.
ISSN:1936-1327
1936-1335
DOI:10.1146/annurev-anchem-061516-045158