New Functionalities for Paper-Based Sensors Lead to Simplified User Operation, Lower Limits of Detection, and New Applications

In the last decade, paper analytical devices (PADs) have evolved into sophisticated yet simple sensors with biological and environmental applications in the developed and developing world. The focus of this review is the technological improvements that have over the past five years increased the app...

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Bibliographic Details
Published in:Annual review of analytical chemistry (Palo Alto, Calif.) Calif.), 2016-06, Vol.9 (1), p.183-202
Main Authors: Cunningham, Josephine C, DeGregory, Paul R, Crooks, Richard M
Format: Article
Language:English
Subjects:
Amplification
Biological evolution
Devices
Fluid dynamics
Fluid flow
Low cost
Mathematical analysis
microfluidic device
paper analytical device
point-of-care
Sensors
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Summary:In the last decade, paper analytical devices (PADs) have evolved into sophisticated yet simple sensors with biological and environmental applications in the developed and developing world. The focus of this review is the technological improvements that have over the past five years increased the applicability of PADs to real-world problems. Specifically, this review reports on advances in sample processing, fluid flow control, signal amplification, and component integration. Throughout, we have sought to emphasize advances that retain the main virtues of PADs: low cost, portability, and simplicity.
ISSN:1936-1327
1936-1335
DOI:10.1146/annurev-anchem-071015-041605