Metals in Protein-Protein Interfaces

From the catalytic reactions that sustain the global oxygen, nitrogen, and carbon cycles to the stabilization of DNA processing proteins, transition metal ions and metallocofactors play key roles in biology. Although the exquisite interplay between metal ions and protein scaffolds has been studied e...

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Bibliographic Details
Published in:Annual review of biophysics 2014-01, Vol.43 (1), p.409-431
Main Authors: Song, Woon Ju, Sontz, Pamela A, Ambroggio, Xavier I, Tezcan, F. Akif
Format: Article
Language:English
Subjects:
Animals
Humans
interfacial metal clusters
metal-mediated oligomerization
metal/metallocofactors
Metals - chemistry
Metals - metabolism
Multiprotein Complexes - chemistry
Multiprotein Complexes - metabolism
protein self-assembly
protein-protein interactions
Proteins - chemistry
Proteins - metabolism
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Summary:From the catalytic reactions that sustain the global oxygen, nitrogen, and carbon cycles to the stabilization of DNA processing proteins, transition metal ions and metallocofactors play key roles in biology. Although the exquisite interplay between metal ions and protein scaffolds has been studied extensively, the fact that the biological roles of the metals often stem from their placement in the interfaces between proteins and protein subunits is not always recognized. Interfacial metal ions stabilize permanent or transient protein-protein interactions, enable protein complexes involved in cellular signaling to adopt distinct conformations in response to environmental stimuli, and catalyze challenging chemical reactions that are uniquely performed by multisubunit protein complexes. This review provides a structural survey of transition metal ions and metallocofactors found in protein-protein interfaces, along with a series of selected examples that illustrate their diverse biological utility and significance.
ISSN:1936-122X
1936-1238
DOI:10.1146/annurev-biophys-051013-023038