Reeling in the Zebrafish Cancer Models

Zebrafish are rapidly becoming a leading model organism for cancer research. The genetic pathways driving cancer are highly conserved between zebrafish and humans, and the ability to easily manipulate the zebrafish genome to rapidly generate transgenic animals makes zebrafish an excellent model orga...

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Bibliographic Details
Published in:Annual review of cancer biology 2021-03, Vol.5 (1), p.331-350
Main Authors: McConnell, Alicia M, Noonan, Haley R, Zon, Leonard I
Format: Article
Language:English
Subjects:
cancer
genetics
modeling
transgenic
tumor
zebrafish
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Summary:Zebrafish are rapidly becoming a leading model organism for cancer research. The genetic pathways driving cancer are highly conserved between zebrafish and humans, and the ability to easily manipulate the zebrafish genome to rapidly generate transgenic animals makes zebrafish an excellent model organism. Transgenic zebrafish containing complex, patient-relevant genotypes have been used to model many cancer types. Here we present a comprehensive review of transgenic zebrafish cancer models as a resource to the field and highlight important areas of cancer biology that have yet to be studied in the fish. The ability to image cancer cells and niche biology in an endogenous tumor makes zebrafish an indispensable model organism in which we can further understand the mechanisms that drive tumorigenesis and screen for potential new cancer therapies.
ISSN:2472-3428
2472-3428
DOI:10.1146/annurev-cancerbio-051320-014135