Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis

One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithel...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of cell and developmental biology 2015-11, Vol.31 (1), p.575-591
Main Authors: Blasky, Alex J, Mangan, Anthony, Prekeris, Rytis
Format: Article
Language:English
Subjects:
Animals
Cell Polarity - physiology
coalescence
epithelial
Epithelial Cells - physiology
Humans
lumenogenesis
Morphogenesis - physiology
Protein Transport - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithelial lumen during tissue morphogenesis. Multiple mechanisms of apical lumen formation have been proposed. Some epithelial lumens form from preexisting polarized epithelial structures. However, de novo lumen formation from nonpolarized cells has recently emerged as an important driver of epithelial tissue morphogenesis, especially during the formation of small epithelial tubule networks. In this review, we discuss the latest findings regarding the mechanisms and regulation of de novo lumen formation in vitro and in vivo.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-100814-125323