Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence

The most fundamental feature of cellular form is size, which sets the scale of all cell biological processes. Growth, form, and function are all necessarily linked in cell biology, but we often do not understand the underlying molecular mechanisms nor their specific functions. Here, we review progre...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 2022-10, Vol.38 (1), p.291-319
Main Authors: Xie, Shicong, Swaffer, Matthew, Skotheim, Jan M
Format: Article
Language:English
Subjects:
Animals
biosynthesis
Cell Size
Cellular Senescence - genetics
Eukaryota
Eukaryotic Cells
senescence
size control
size scaling
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Summary:The most fundamental feature of cellular form is size, which sets the scale of all cell biological processes. Growth, form, and function are all necessarily linked in cell biology, but we often do not understand the underlying molecular mechanisms nor their specific functions. Here, we review progress toward determining the molecular mechanisms that regulate cell size in yeast, animals, and plants, as well as progress toward understanding the function of cell size regulation. It has become increasingly clear that the mechanism of cell size regulation is deeply intertwined with basic mechanisms of biosynthesis, and how biosynthesis can be scaled (or not) in proportion to cell size. Finally, we highlight recent findings causally linking aberrant cell size regulation to cellular senescence and their implications for cancer therapies.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-120219-040142