Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated mole...

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Bibliographic Details
Published in:Annual review of food science and technology 2015-04, Vol.6 (1), p.505-526
Main Authors: DiMarco-Crook, Christina, Xiao, Hang
Format: Article
Language:English
Subjects:
breast cancer
cancer chemoprevention
Chemoprevention
colorectal cancer
combination
dietary bioactive components
Female
Humans
lung cancer
Male
Neoplasms - classification
Neoplasms - diet therapy
Neoplasms - prevention & control
prostate cancer
synergy
whole foods
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Summary:Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated molecular pathways associated with the initiation and progression of different types of cancer. Combination regimens with dietary bioactive components are a promising strategy for cancer chemoprevention because they may offer enhanced protective effects against cancer development but cause little or no adverse effects. This article provides an overview of studies examining the combination of dietary bioactive components for the chemoprevention of major types of cancer. A better understanding of existing research on the combination of dietary bioactive components will provide an important basis for the rational design of future combination studies and the successful development of cancer chemoprevention strategies.
ISSN:1941-1413
1941-1421
DOI:10.1146/annurev-food-081114-110833