DIAGNOSIS AND TREATMENT OF PRE-INSULIN DEPENDENT DIABETES

The development of genetic and serological markers of autoimmune Type I diabetes has allowed us to begin to identify subjects at risk for the development of Type I diabetes. Assessment of these variables can assign risk to subjects and permit the implementation of immune intervention trials in an at...

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Bibliographic Details
Published in:Annual review of medicine 1998-01, Vol.49 (1), p.391-405
Main Authors: Gottlieb, MD, P. A, Eisenbarth, MD, PhD, G. S
Format: Article
Language:English
Subjects:
autoantibodies
Autoantibodies - blood
Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - genetics
Autoimmune Diseases - prevention & control
Autoimmune Diseases - therapy
autoimmunity
Biological and medical sciences
Biomarkers - blood
Clinical Trials as Topic
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - prevention & control
Diabetes Mellitus, Type 1 - therapy
Diabetes. Impaired glucose tolerance
Disease prevention
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Forecasting
Gene Expression
Genetic Markers
Genetics
Haplotypes
Humans
Immunotherapy
Medical sciences
Patients
Prediabetic State - blood
Prediabetic State - diagnosis
Prediabetic State - genetics
Prediabetic State - immunology
Prediabetic State - prevention & control
Prediabetic State - therapy
prediction
prevention
Risk Factors
T cell receptors
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Description
Summary:The development of genetic and serological markers of autoimmune Type I diabetes has allowed us to begin to identify subjects at risk for the development of Type I diabetes. Assessment of these variables can assign risk to subjects and permit the implementation of immune intervention trials in an attempt to alter the course of pre-diabetes. This review discusses relevant aspects of the genetics and diagnosis of pre-diabetes, and both current and future clinical trials that are attempting to prevent the full expression of clinical diabetes in these individuals.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.49.1.391