The Anatomy and Physiology of Claustrum-Cortex Interactions

The claustrum is one of the most widely connected regions of the forebrain, yet its function has remained obscure, largely due to the experimentally challenging nature of targeting this small, thin, and elongated brain area. However, recent advances in molecular techniques have enabled the anatomy a...

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Bibliographic Details
Published in:Annual review of neuroscience 2020-07, Vol.43 (1), p.231-247
Main Authors: Jackson, Jesse, Smith, Jared B, Lee, Albert K
Format: Article
Language:English
Subjects:
Anatomy
Anatomy & physiology
attention
Basal ganglia
Cell interactions
claustrum
feedforward inhibition
Forebrain
limbic-motor interface
Neural networks
Physiology
prefrontal cortex
salience network
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Summary:The claustrum is one of the most widely connected regions of the forebrain, yet its function has remained obscure, largely due to the experimentally challenging nature of targeting this small, thin, and elongated brain area. However, recent advances in molecular techniques have enabled the anatomy and physiology of the claustrum to be studied with the spatiotemporal and cell type-specific precision required to eventually converge on what this area does. Here we review early anatomical and electrophysiological results from cats and primates, as well as recent work in the rodent, identifying the connectivity, cell types, and physiological circuit mechanisms underlying the communication between the claustrum and the cortex. The emerging picture is one in which the rodent claustrum is closely tied to frontal limbic regions and plays a role in processes, such as attention, that are associated with these areas.
ISSN:0147-006X
1545-4126
DOI:10.1146/annurev-neuro-092519-101637