Regulation of Vascular and Renal Function by Metabolite Receptors

To maintain metabolic homeostasis, the body must be able to monitor the concentration of a large number of substances, including metabolites, in real time and to use that information to regulate the activities of different metabolic pathways. Such regulation is achieved by the presence of sensors, t...

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Bibliographic Details
Published in:Annual review of physiology 2016-01, Vol.78 (1), p.391-414
Main Authors: Peti-Peterdi, János, Kishore, Bellamkonda K, Pluznick, Jennifer L
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - metabolism
Blood Vessels - physiology
Cells
gut microbiota
Homeostasis
Homeostasis - physiology
Humans
Information
Kidney - metabolism
Kidney - physiology
Kidneys
Metabolites
mitochondria
nucleotides
Receptors, Cell Surface - metabolism
SCFA
short-chain fatty acids
Tissues
vascularization
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Summary:To maintain metabolic homeostasis, the body must be able to monitor the concentration of a large number of substances, including metabolites, in real time and to use that information to regulate the activities of different metabolic pathways. Such regulation is achieved by the presence of sensors, termed metabolite receptors, in various tissues and cells of the body, which in turn convey the information to appropriate regulatory or positive or negative feedback systems. In this review, we cover the unique roles of metabolite receptors in renal and vascular function. These receptors play a wide variety of important roles in maintaining various aspects of homeostasis-from salt and water balance to metabolism-by sensing metabolites from a wide variety of sources. We discuss the role of metabolite sensors in sensing metabolites generated locally, metabolites generated at distant tissues or organs, or even metabolites generated by resident microbes. Metabolite receptors are also involved in various pathophysiological conditions and are being recognized as potential targets for new drugs. By highlighting three receptor families-( a ) citric acid cycle intermediate receptors, ( b ) purinergic receptors, and ( c ) short-chain fatty acid receptors-we emphasize the unique and important roles that these receptors play in renal and vascular physiology and pathophysiology.
ISSN:0066-4278
1545-1585
DOI:10.1146/annurev-physiol-021115-105403