The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs

• Published in: Antimicrobial Agents and Chemotherapy 2011-06, Vol.55 (6), p.2552-2558
• Main Authors: Wang, Liya, Sun, Ren, Eriksson, Staffan
• Format: Article
• Language: English
• Subjects: Animal and Dairy Science; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - toxicity; Biological and medical sciences; Dideoxynucleosides; Dideoxynucleosides - toxicity; Female; Human immunodeficiency virus; Husdjursvetenskap; Kinetics; Medical sciences; Mitochondria; Mitochondria - drug effects; Pharmacology. Drug treatments; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine Kinase; Thymidine Kinase - metabolism; Thymine Nucleotides; Thymine Nucleotides - metabolism; Veterinary Science; Veterinärmedicin; Zidovudine; Zidovudine - metabolism; Zidovudine - toxicity
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/aac.00109-11

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