In Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcusaureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcusfaecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin

We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcusfaecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2009-12, Vol.53 (12), p.5300-5302
Main Authors: Jacqueline, Cédric, Caillon, Jocelyne, Le Mabecque, Virginie, Miègeville, Anne-Françoise, Ge, Yigong, Biek, Donald, Batard, Eric, Potel, Gilles
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Cephalosporins
Enterococcus faecalis
Experimental Therapeutics
Methicillin-Resistant Staphylococcus aureus
Vancomycin
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcusfaecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates of E. faecalis.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00984-09