Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis

• Published in: Antimicrobial Agents and Chemotherapy 2013-03, Vol.57 (3), p.1385-1393
• Main Authors: FISCHER, Carrie D, BEATTY, Jennifer K, DUQUETTE, Stephanie C, MORCK, Douglas W, LUCAS, Merlyn J, BURET, André G
• Format: Article
• Language: English
• Subjects: Alveoli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Apoptosis; Apoptosis - drug effects; Apoptosis - immunology; Biological and medical sciences; Caspase 3 - genetics; Caspase 3 - metabolism; Cattle; Cells, Cultured; Cysteine Proteinase Inhibitors - pharmacology; Disaccharides; Disaccharides - pharmacology; Gene Expression Regulation - drug effects; Heterocyclic Compounds; Heterocyclic Compounds - pharmacology; Immunologic Factors; Immunologic Factors - pharmacology; Inflammation - immunology; Inflammation - prevention & control; Interleukin-8; Interleukin-8 - antagonists & inhibitors; Interleukin-8 - biosynthesis; Interleukin-8 - immunology; Lipopolysaccharides - pharmacology; Macrophages, Alveolar; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - immunology; Macrophages, Alveolar - microbiology; Male; Mannheimia; Mannheimia haemolytica - drug effects; Mannheimia haemolytica - growth & development; Mechanisms of Action: Physiological Effects; Medical sciences; Neutrophils - drug effects; Neutrophils - immunology; Neutrophils - microbiology; Oligopeptides - pharmacology; Phagocytosis; Phagocytosis - drug effects; Pharmacology. Drug treatments; Pneumonia of Calves, Enzootic; Pneumonia of Calves, Enzootic - drug therapy; Pneumonia of Calves, Enzootic - immunology; Pneumonia of Calves, Enzootic - pathology; Signal Transduction - drug effects
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01598-12

Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • [e-mail] Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC