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Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation
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| Published in: | Antimicrobial Agents and Chemotherapy 2013-02, Vol.57 (2), p.901-906 |
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| Main Authors: | , , |
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| cited_by | cdi_FETCH-LOGICAL-a506t-3b03098c6e26bbec67ec0ef043053cde0a203cca48c2a17d28c477baa52fd4023 |
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| cites | cdi_FETCH-LOGICAL-a506t-3b03098c6e26bbec67ec0ef043053cde0a203cca48c2a17d28c477baa52fd4023 |
| container_end_page | 906 |
| container_issue | 2 |
| container_start_page | 901 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 57 |
| creator | WYLLIE, Susan PATTERSON, Stephen FAIRLAMB, Alan H |
| description | OA
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| doi_str_mv | 10.1128/AAC.01788-12 |
| format | article |
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1752 N Street N.W. • Washington DC 20036
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Print ISSN:
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</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Data processing</subject><subject>Drug Resistance</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Gene Knockout Techniques</subject><subject>Leishmania donovani</subject><subject>Leishmania donovani - drug effects</subject><subject>Leishmania donovani - enzymology</subject><subject>Leishmania donovani - growth & development</subject><subject>Leishmaniasis, Visceral - drug therapy</subject><subject>Mammalian cells</subject><subject>Mechanisms of Action: Physiological Effects</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Nitro Compounds - pharmacology</subject><subject>Nitroimidazole</subject><subject>Nitroimidazoles</subject><subject>Nitroimidazoles - pharmacology</subject><subject>Nitroreductase</subject><subject>Nitroreductases</subject><subject>Nitroreductases - genetics</subject><subject>Nitroreductases - metabolism</subject><subject>NTR gene</subject><subject>Parasites</subject><subject>Pharmacology. Drug treatments</subject><subject>prodrugs</subject><subject>Promastigotes</subject><subject>Survival</subject><subject>Trypanocidal Agents</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma brucei</subject><subject>Visceral leishmaniasis</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhSMEotvCjTPyBYlKpIzt2HEuSNFSoNIKJARna-I4u66ydrGTRf33uGQpcECc7NF8fvPGryieUbiglKnXbbu-AForVVL2oFhRaFQpRSMfFisAKctKQXVSnKZ0DbkWDTwuThhnoGoqV8XQpmRTcn5Lpp0ll7nyk8PRTbckDGRjXdrt0TskffDhkG_ko5tiiLafzYTJEvQ9uZoS-RxGS5xf2uRtnLekNZM74OSCf1I8GnBM9unxPCu-vrv8sv5Qbj69v1q3mxIFyKnkHfDs30jLZNdZI2trwA5QcRDc9BaQATcGK2UY0rpnylR13SEKNvQVMH5WvFl0b-Zub3uTl4k46pvo9hhvdUCn_-54t9PbcNBcCF5XkAVeHgVi-DbbNOm9S8aOI3ob5qQpp0JSELX4P8pqrkAxdWfr1YKaGFKKdrh3REHfpahzivpnivlZxs8XHNOe6eswR58_7V_s8z83vhf-FXEGXhwBTAbHIaI3Lv3mZAOyUSpzZOF2brv77qLVebpGNFrUmukGKP8BwvO9aw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>WYLLIE, Susan</creator><creator>PATTERSON, Stephen</creator><creator>FAIRLAMB, Alan H</creator><general>American Society for Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation</title><author>WYLLIE, Susan ; PATTERSON, Stephen ; FAIRLAMB, Alan H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a506t-3b03098c6e26bbec67ec0ef043053cde0a203cca48c2a17d28c477baa52fd4023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Data processing</topic><topic>Drug Resistance</topic><topic>Drugs</topic><topic>Enzymes</topic><topic>Gene Knockout Techniques</topic><topic>Leishmania donovani</topic><topic>Leishmania donovani - drug effects</topic><topic>Leishmania donovani - enzymology</topic><topic>Leishmania donovani - growth & development</topic><topic>Leishmaniasis, Visceral - drug therapy</topic><topic>Mammalian cells</topic><topic>Mechanisms of Action: Physiological Effects</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Nitro Compounds - pharmacology</topic><topic>Nitroimidazole</topic><topic>Nitroimidazoles</topic><topic>Nitroimidazoles - pharmacology</topic><topic>Nitroreductase</topic><topic>Nitroreductases</topic><topic>Nitroreductases - genetics</topic><topic>Nitroreductases - metabolism</topic><topic>NTR gene</topic><topic>Parasites</topic><topic>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>23208716</pmid><doi>10.1128/AAC.01788-12</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.901-906 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_asm2_journals_10_1128_AAC_01788_12 |
| source | Open Access: PubMed Central; ASM_美国微生物学会期刊 |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Line Data processing Drug Resistance Drugs Enzymes Gene Knockout Techniques Leishmania donovani Leishmania donovani - drug effects Leishmania donovani - enzymology Leishmania donovani - growth & development Leishmaniasis, Visceral - drug therapy Mammalian cells Mechanisms of Action: Physiological Effects Medical sciences Metabolites Nitro Compounds - pharmacology Nitroimidazole Nitroimidazoles Nitroimidazoles - pharmacology Nitroreductase Nitroreductases Nitroreductases - genetics Nitroreductases - metabolism NTR gene Parasites Pharmacology. Drug treatments prodrugs Promastigotes Survival Trypanocidal Agents Trypanocidal Agents - pharmacology Trypanosoma brucei Visceral leishmaniasis |
| title | Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation |
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