Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus

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Published in:Antimicrobial Agents and Chemotherapy 1996-08, Vol.40 (8), p.1835-1842
Main Authors: TAKENOUCHI, T, TABATA, F, IWATA, Y, HANZAWA, H, SUGAWARA, M, OHYA, S
Format: Article
Language:English
Subjects:
Anti-Infective Agents
Anti-Infective Agents - chemistry
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological and medical sciences
Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II - genetics
Drug Resistance, Microbial
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - metabolism
Fluoroquinolones
Medical sciences
Microbial Sensitivity Tests
Multidrug Resistance-Associated Proteins
Norfloxacin - chemistry
Norfloxacin - metabolism
Norfloxacin - pharmacology
Pharmacology. Drug treatments
Piperazines - chemistry
Piperazines - metabolism
Piperazines - pharmacology
Point Mutation
Quinolones - chemistry
Quinolones - metabolism
Quinolones - pharmacology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - metabolism
Structure-Activity Relationship
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Summary:Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.40.8.1835