Antifungal Efficacy, Safety, and Single-Dose Pharmacokinetics of LY303366, a Novel Echinocandin B, in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits

• Published in: Antimicrobial Agents and Chemotherapy 1998-11, Vol.42 (11), p.2898-2905
• Main Authors: PETRAITIS, V, PETRAITIENE, R, GROLL, A. H, BELL, A, CALLENDER, D. P, SEIN, T, SCHAUFELE, R. L, MCMILLIAN, C. L, BACHER, J, WALSH, T. J
• Format: Article
• Language: English
• Subjects: Amphotericin B - administration & dosage; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - therapeutic use; Aspergillosis; Aspergillosis - drug therapy; Aspergillosis - prevention & control; Aspergillus fumigatus; Aspergillus fumigatus - drug effects; Biological and medical sciences; Dose-Response Relationship, Drug; Echinocandins; Experimental Therapeutics; Female; Lung Diseases, Fungal; Lung Diseases, Fungal - drug therapy; Lung Diseases, Fungal - prevention & control; Medical sciences; Neutropenia; Neutropenia - complications; Neutropenia - drug therapy; Neutropenia - prevention & control; Peptides, Cyclic; Peptides, Cyclic - adverse effects; Peptides, Cyclic - pharmacokinetics; Peptides, Cyclic - therapeutic use; Pharmacology. Drug treatments; Rabbits
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.42.11.2898

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