The Assessment of Frequency Estimates of Hae III-Generated VNTR Profiles in Various Reference Databases

The likelihood of occurrence of 1964 Hae III-generated target DNA profiles was estimated using fixed bin frequencies from various regional and ethnic databases and the multiplication rule. The databases generally were from the following major categories: Black, Caucasian, Hispanic, Oriental, and Ame...

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Bibliographic Details
Published in:Journal of forensic sciences 1994-03, Vol.39 (2), p.319-352
Main Authors: Budowle, B, Monson, KL, Giusti, AM, Brown, BL
Format: Article
Language:English
Subjects:
Bias
Confidence Intervals
Databases, Factual
Deoxyribonucleases, Type II Site-Specific
DNA Fingerprinting
Ethnic Groups - genetics
Evaluation Studies as Topic
Forensic Medicine
Gene Frequency
Humans
Likelihood Functions
Polymorphism, Restriction Fragment Length
Reference Values
Repetitive Sequences, Nucleic Acid
Reproducibility of Results
Residence Characteristics
Restriction Mapping
United States
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Summary:The likelihood of occurrence of 1964 Hae III-generated target DNA profiles was estimated using fixed bin frequencies from various regional and ethnic databases and the multiplication rule. The databases generally were from the following major categories: Black, Caucasian, Hispanic, Oriental, and American Indian. It was found that subdivision, either by ethnic group or by U.S. geographic region, within a major population group did not substantially affect forensic estimates of the likelihood of occurrence of a DNA profile. As expected, the greatest variation in estimates for within-group estimates was among American Indian databases. Because the greatest variation in statistical estimates occurs across-major population groups, in most cases, there will be no unfair bias applying general population database estimates. Therefore, based on empirical data, there is no demonstrable need for using alternate approaches, such as the ceiling approach, to derive statistical estimates. The current practice of using general population databases and the multiplication rule provides valid estimates of the likelihood of occurrence of a DNA profile.
ISSN:0022-1198
1556-4029
DOI:10.1520/JFS13605J