Feasibility Study on Functionalization of Mesoporous Titanium Dioxide by Electron Beam Irradiation for Smart Delivery of Oncology Drugs

• Published in: Journal of testing and evaluation 2021-05, Vol.49 (3), p.1814-1823
• Main Authors: Ghafoorzadeh, S., Askarbioki, M., Shirmardi, S. P., Khakshournia, S., Kargar, S., Amooee, A., Ranjbar Jamalabadi, R., Saniei, E.
• Format: Article
• Language: English
• ISSN: 0090-3973; 1945-7553
• DOI: 10.1520/JTE20200192

Titanium oxide (TiO2) is used as a heterogeneous catalyst in many chemical processes. Because of its high surface area and uniform channels, titania is also used for material transfer in reactions and targeted drug delivery systems, particularly hematology and oncology drugs. This study aims to functionalize titania by electron beam irradiation and achieve optimal irradiation dose conditions for the smart delivery of hematology drugs. Functionalized TiO2 with 3-aminopropyl-trimethoxysilane (APTS), 3-methoxybenzyl alcohol, 2-nitrobenzyl alcohol, 2,4-dinitrobenzyl alcohol 4-nitrobenzyl alcohol is a suitable compound for medical and intelligent drug delivery purposes. To this end, TiO2 was first synthesized by the sol-gel method, and then using Fourier-transform spectroscopy, the functionalization of the mentioned compounds and the effects of different irradiation doses and reactants were investigated. The irradiation dose and the type of alcohol are very important factors for the functionalization of TiO2, which are discussed in this article, and finally, the optimal dose and the functionalization reaction mechanisms are proposed. In optimum irradiation conditions, 3-APTS, 3-methoxybenzyl alcohol, 2-nitrobenzyl alcohol, 2,4-dinitrobenzyl alcohol 4-nitrobenzyl alcohol were successfully grafted onto TiO2, which can be used successfully as controlled hematology drugs delivery systems. The use of an electron irradiation technique for the functionalization of mesoporous titania compounds has many advantages over similar chemical methods such as higher reaction speed, higher efficiency, and lower chemical contamination.